SEPT11

SEPT11
Identifikatori
Aliasi	SEPTIN11
Vanjski ID-jevi	OMIM: 612887 MGI: 1277214 HomoloGene: 56800 GeneCards: SEPTIN11
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	77,040,384 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	93,324,306 bp
Ontologija gena
Molekularna funkcija	• nucleotide binding; • GTP binding; • GO:0001948, GO:0016582 vezivanje za proteine; • GO:0006184 GTPase activity; • GO:0032947 molecular adaptor activity;
Ćelijska komponenta	• citoplazma; • Akson; • međućelijske veze; • dendritična kičma; • projekcija ćelije; • sinapsa; • citoskelet; • stress fiber; • postsynapse; • glutamatergic synapse; • GABA-ergic synapse; • postsynaptic specialization of symmetric synapse; • septin ring; • microtubule cytoskeleton; • septin complex; • septin filament array;
Biološki proces	• ćelijski ciklus; • protein heterooligomerization; • Ćelijska dioba; • GO:1904739 regulation of synapse organization; • mitotic cytokinesis; • septin ring assembly; • cilium assembly; • cytoskeleton-dependent cytokinesis;
	Izvori:Amigo / QuickGO
Ortolozi
	55752
	52398
	ENSG00000138758
	ENSMUSG00000058013
	Q9NVA2
	Q8C1B7
	NM_001306147; NM_018243
	NM_001009818; NM_001310669; NM_001310671; NM_001347377
	NP_001293076; NP_060713
	NP_001009818; NP_001297598; NP_001297600; NP_001334306
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Septin-11 jest protein koji je kod ljudi kodiran genom SEPT11 sa hromosoma 4.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 429 aminokiselina, а molekulska težina 49.398 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAVAVGRPSN	EELRNLSLSG	HVGFDSLPDQ	LVNKSTSQGF	CFNILCVGET
GIGKSTLMDT	LFNTKFESDP	ATHNEPGVRL	KARSYELQES	NVRLKLTIVD
TVGFGDQINK	DDSYKPIVEY	IDAQFEAYLQ	EELKIKRSLF	NYHDTRIHAC
LYFIAPTGHS	LKSLDLVTMK	KLDSKVNIIP	IIAKADTIAK	NELHKFKSKI
MSELVSNGVQ	IYQFPTDEET	VAEINATMSV	HLPFAVVGST	EEVKIGNKMA
KARQYPWGVV	QVENENHCDF	VKLREMLIRV	NMEDLREQTH	TRHYELYRRC
KLEEMGFKDT	DPDSKPFSLQ	ETYEAKRNEF	LGELQKKEEE	MRQMFVMRVK
EKEAELKEAE	KELHEKFDLL	KRTHQEEKKK	VEDKKKELEE	EVNNFQKKKA
AAQLLQSQAQ	QSGAQQTKKD	KDKKNASFT

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138758 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058013 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kojima K, Sakai I, Hasegawa A, Niiya H, Azuma T, Matsuo Y, Fujii N, Tanimoto M, Fujita S (maj 2004). "FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23)". Leukemia. 18 (5): 998–1005. doi:10.1038/sj.leu.2403334. PMID 14999297.
^ Kim DS, Hubbard SL, Peraud A, Salhia B, Sakai K, Rutka JT (maj 2004). "Analysis of mammalian septin expression in human malignant brain tumors". Neoplasia. 6 (2): 168–78. doi:10.1593/neo.03310. PMC 1502092. PMID 15140406.
^ "Entrez Gene: SEPT11 septin 11".
^ "UniProt, Q9NVA2" (jezik: engleski). Pristupljeno 30. 10. 2021.

Dopunska literatura

Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (januar 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (juni 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (maj 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Hanai N, Nagata K, Kawajiri A, Shiromizu T, Saitoh N, Hasegawa Y, Murakami S, Inagaki M (juni 2004). "Biochemical and cell biological characterization of a mammalian septin, Sept11". FEBS Letters. 568 (1–3): 83–8. doi:10.1016/j.febslet.2004.05.030. PMID 15196925. S2CID 11315113.
Nagata K, Asano T, Nozawa Y, Inagaki M (decembar 2004). "Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11". The Journal of Biological Chemistry. 279 (53): 55895–904. doi:10.1074/jbc.M406153200. PMID 15485874.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (januar 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Sudo K, Ito H, Iwamoto I, Morishita R, Asano T, Nagata K (oktobar 2007). "SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling". Human Mutation. 28 (10): 1005–13. doi:10.1002/humu.20554. PMID 17546647. S2CID 40174453.
Xin X, Pache M, Zieger B, Bartsch I, Prünte C, Flammer J, Meyer P (novembar 2007). "Septin expression in proliferative retinal membranes". The Journal of Histochemistry and Cytochemistry. 55 (11): 1089–94. doi:10.1369/jhc.7A7188.2007. PMC 3957527. PMID 17625225.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138758 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058013 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14999297-5] Kojima K, Sakai I, Hasegawa A, Niiya H, Azuma T, Matsuo Y, Fujii N, Tanimoto M, Fujita S (maj 2004). "FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23)". Leukemia. 18 (5): 998–1005. doi:10.1038/sj.leu.2403334. PMID 14999297.

[pmid15140406-6] Kim DS, Hubbard SL, Peraud A, Salhia B, Sakai K, Rutka JT (maj 2004). "Analysis of mammalian septin expression in human malignant brain tumors". Neoplasia. 6 (2): 168–78. doi:10.1593/neo.03310. PMC 1502092. PMID 15140406.

[entrez-7] "Entrez Gene: SEPT11 septin 11".

[UniProt-8] "UniProt, Q9NVA2" (jezik: engleski). Pristupljeno 30. 10. 2021.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]