RELT

RELT
Identifikatori
Aliasi	RELT
Vanjski ID-jevi	OMIM: 611211 MGI: 2443373 HomoloGene: 13151 GeneCards: RELT
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	73,397,474 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	100,512,653 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• tumor necrosis factor-activated receptor activity; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma; • integral component of membrane; • ćelijska membrana; • integral component of plasma membrane; • membrana; • jedro; • perinuklearno područje citoplazme;
Biološki proces	• multicellular organism development; • regulation of apoptotic process; • apoptotic signaling pathway; • response to lipopolysaccharide; • inflammatory response; • regulation of cell population proliferation; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • tumor necrosis factor-mediated signaling pathway; • GO:0097285 apoptoza;
	Izvori:Amigo / QuickGO
Ortolozi
	84957
	320100
	ENSG00000054967
	ENSMUSG00000008318
	Q969Z4
	Q8BX43
	NM_032871; NM_152222
	NM_177073; NM_001358914
	NP_116260; NP_689408
	NP_796047; NP_001345843
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 19L supertporodice receptora tumorske necroze je protein koji je kod ljudi kodiran genom RELT.^[5]^[6]^[7]^[8]^[9]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 430 aminokiselina, a molekulska težina 46.092 Da.^[10]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKPSLLCRPL	SCFLMLLPWP	LATLTSTTLW	QCPPGEEPDL	DPGQGTLCRP
CPPGTFSAAW	GSSPCQPHAR	CSLWRRLEAQ	VGMATRDTLC	GDCWPGWFGP
WGVPRVPCQP	CSWAPLGTHG	CDEWGRRARR	GVEVAAGASS	GGETRQPGNG
TRAGGPEETA	AQYAVIAIVP	VFCLMGLLGI	LVCNLLKRKG	YHCTAHKEVG
PGPGGGGSGI	NPAYRTEDAN	EDTIGVLVRL	ITEKKENAAA	LEELLKEYHS
KQLVQTSHRP	VSKLPPAPPN	VPHICPHRHH	LHTVQGLASL	SGPCCSRCSQ
KKWPEVLLSP	EAVAATTPVP	SLLPNPTRVP	KAGAKAGRQG	EITILSVGRF
RVARIPEQRT	SSMVSEVKTI	TEAGPSWGDL	PDSPQPGLPP	EQQALLGSGG
SRTKWLKPPA	ENKAEENRYV	VRLSESNLVI

Funkcija

Protein kodiran ovim genom je član natporodice TNF-receptora. Ovaj receptor je posebno bogat krvnim tkivima. Pokazalo se da aktivira NF-kapaB put i selektivno veže faktor 1 (TRAF1) povezan sa TNF receptorima. Ovaj receptor je sposoban stimulirati proliferaciju T-ćelija u prisustvu signala CD3, što sugerira njegovu regulatornu ulogu u imunskom odgovoru. Prijavljene su dvije alternativno prerađene varijante transkripta ovog gena koje kodiraju isti protein.^[9]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000054967 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008318 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sica GL, Zhu G, Tamada K, Liu D, Ni J, Chen L (Apr 2001). "RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB". Blood. 97 (9): 2702–7. doi:10.1182/blood.V97.9.2702. PMID 11313261. S2CID 6347356.
^ Bossen C, Ingold K, Tardivel A, Bodmer JL, Gaide O, Hertig S, Ambrose C, Tschopp J, Schneider P (maj 2006). "Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human". J Biol Chem. 281 (20): 13964–71. doi:10.1074/jbc.M601553200. PMID 16547002.
^ Polek TC, Talpaz M, Spivak-Kroizman TR (Sep 2006). "TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis". Biochem Biophys Res Commun. 349 (3): 1016–24. doi:10.1016/j.bbrc.2006.08.118. PMID 16950202.
^ Cusick JK, Xu LG, Bin LH, Han KJ, Shu HB (Jan 2006). "Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1". Biochem Biophys Res Commun. 340 (2): 535–43. doi:10.1016/j.bbrc.2005.12.033. PMID 16389068.
^ ^a ^b "Entrez Gene: TNFRSF19L tumor necrosis factor receptor superfamily, member 19-like".
^ "UniProt, Q969Z4". Pristupljeno 26. 8. 2021.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000054967 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008318 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11313261-5] Sica GL, Zhu G, Tamada K, Liu D, Ni J, Chen L (Apr 2001). "RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB". Blood. 97 (9): 2702–7. doi:10.1182/blood.V97.9.2702. PMID 11313261. S2CID 6347356.

[pmid16547002-6] Bossen C, Ingold K, Tardivel A, Bodmer JL, Gaide O, Hertig S, Ambrose C, Tschopp J, Schneider P (maj 2006). "Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human". J Biol Chem. 281 (20): 13964–71. doi:10.1074/jbc.M601553200. PMID 16547002.

[pmid16950202-7] Polek TC, Talpaz M, Spivak-Kroizman TR (Sep 2006). "TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis". Biochem Biophys Res Commun. 349 (3): 1016–24. doi:10.1016/j.bbrc.2006.08.118. PMID 16950202.

[pmid16389068-8] Cusick JK, Xu LG, Bin LH, Han KJ, Shu HB (Jan 2006). "Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1". Biochem Biophys Res Commun. 340 (2): 535–43. doi:10.1016/j.bbrc.2005.12.033. PMID 16389068.

[entrez-9] "Entrez Gene: TNFRSF19L tumor necrosis factor receptor superfamily, member 19-like".

[UniProt-10] "UniProt, Q969Z4". Pristupljeno 26. 8. 2021.

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