ODF1

ODF1
Identifikatori
Aliasi	ODF1
Vanjski ID-jevi	OMIM: 182878 MGI: 97424 HomoloGene: 7456 GeneCards: ODF1
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	102,561,018 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	38,226,979 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • protein domain specific binding;
Ćelijska komponenta	• jedro; • outer dense fiber;
Biološki proces	• multicellular organism development; • Ćelijska diferencijacija; • Spermatogeneza;
	Izvori:Amigo / QuickGO
Ortolozi
	4956
	18285
	ENSG00000155087
	ENSMUSG00000061923
	Q14990
	Q61999
	NM_024410
	NM_008757
	NP_077721
	NP_032783
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Vanjski gusti vlaknasti protein 1 je protein koji je kod ljudi kodiran genom ODF1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 250 aminokiselina, а molekulska težina 28.366 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAALSCLLDS	VRRDIKKVDR	ELRQLRCIDE	FSTRCLCDLY	MHPYCCCDLH
PYPYCLCYSK	RSRSCGLCDL	YPCCLCDYKL	YCLRPSLRSL	ERKAIRAIED
EKRELAKLRR	TTNRILASSC	CSSNILGSVN	VCGFEPDQVK	VRVKDGKVCV
SAERENRYDC	LGSKKYSYMN	ICKEFSLPPC	VDEKDVTYSY	GLGSCVKIES
PCYPCTSPCS	PCSPCSPCNP	CSPCNPCSPY	DPCNPCYPCG	SRFSCRKMIL

Funkcija

Vanjska gusta vlakna su citoskeletne strukture koje okružuju aksonemu u srednjem dijelu i glavnom dijelu spermatozoidnog repa. Vlakna funkcioniraju u održavanju elastične strukture i kretanju spermatozoidnog repa, kao i u zaštiti repa od smicajućih sila tokom epididimisnog transporta i ejakulacija. Defekti vanjskih gustih vlakana dovode do abnormalne morfologije sperme i neplodnosti. Ljudska vanjska gusta vlakna sadrže najmanje 10 glavnih proteina, a ovaj gen kodira glavni protein.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155087 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061923 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gastmann O, Burfeind P, Gunther E, Hameister H, Szpirer C, Hoyer-Fender S (Mar 1994). "Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene". Mol Reprod Dev. 36 (4): 407–418. doi:10.1002/mrd.1080360402. PMID 8305202. S2CID 2447785.
^ ^a ^b "Entrez Gene: ODF1 outer dense fiber of sperm tails 1".
^ "UniProt, Q14990" (jezik: engleski). Pristupljeno 20. 9. 2021.

Dopunska literatura

Kierszenbaum AL (2002). "Keratins: unraveling the coordinated construction of scaffolds in spermatogenic cells". Mol. Reprod. Dev. 61 (1): 1–2. doi:10.1002/mrd.1124. PMID 11774369. S2CID 28475473.
Henkel R, Stalf T, Miska W (1992). "Isolation and partial characterization of the outer dense fiber proteins from human spermatozoa". Biol. Chem. Hoppe-Seyler. 373 (8): 685–9. doi:10.1515/bchm3.1992.373.2.685. PMID 1418683.
Hofferbert S, Burfeind P, Hoyer-Fender S, et al. (1994). "A homozygous deletion of 27 basepairs in the coding region of the human outer dense fiber protein gene does not result in a pathologic phenotype". Hum. Mol. Genet. 2 (12): 2167–2170. doi:10.1093/hmg/2.12.2167. PMID 8111388.
Burmester S, Hoyer-Fender S (1997). "Transcription and translation of the outer dense fiber gene (Odf1) during spermiogenesis in the rat. A study by in situ analyses and polysome fractionation". Mol. Reprod. Dev. 45 (1): 10–20. doi:10.1002/(SICI)1098-2795(199609)45:1<10::AID-MRD2>3.0.CO;2-V. PMID 8873064.
Shao X, van der Hoorn FA (1997). "Self-interaction of the major 27-kilodalton outer dense fiber protein is in part mediated by a leucine zipper domain in the rat". Biol. Reprod. 55 (6): 1343–1350. doi:10.1095/biolreprod55.6.1343. PMID 8949892.
Shao X, Tarnasky HA, Schalles U, et al. (1997). "Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27". J. Biol. Chem. 272 (10): 6105–6113. doi:10.1074/jbc.272.10.6105. PMID 9045620.
Shao X, Tarnasky HA, Lee JP, et al. (1999). "Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme". Dev. Biol. 211 (1): 109–123. doi:10.1006/dbio.1999.9297. PMID 10373309.
Petersen C, Füzesi L, Hoyer-Fender S (1999). "Outer dense fibre proteins from human sperm tail: molecular cloning and expression analyses of two cDNA transcripts encoding proteins of approximately 70 kDa". Mol. Hum. Reprod. 5 (7): 627–635. doi:10.1093/molehr/5.7.627. PMID 10381817.
Shao X, Xue J, van der Hoorn FA (2001). "Testicular protein Spag5 has similarity to mitotic spindle protein Deepest and binds outer dense fiber protein Odf1". Mol. Reprod. Dev. 59 (4): 410–416. doi:10.1002/mrd.1047. PMID 11468777. S2CID 13590694.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zarsky HA, Tarnasky HA, Cheng M, van der Hoorn FA (2003). "Novel RING finger protein OIP1 binds to conserved amino acid repeats in sperm tail protein ODF1". Biol. Reprod. 68 (2): 543–552. doi:10.1095/biolreprod.102.009076. PMC 3158802. PMID 12533418.
Bhullar B, Zhang Y, Junco A, et al. (2003). "Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion". J. Biol. Chem. 278 (18): 16159–16168. doi:10.1074/jbc.M213126200. PMC 3178653. PMID 12863206.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155087 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061923 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8305202-5] Gastmann O, Burfeind P, Gunther E, Hameister H, Szpirer C, Hoyer-Fender S (Mar 1994). "Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene". Mol Reprod Dev. 36 (4): 407–418. doi:10.1002/mrd.1080360402. PMID 8305202. S2CID 2447785.

[entrez-6] "Entrez Gene: ODF1 outer dense fiber of sperm tails 1".

[UniProt-7] "UniProt, Q14990" (jezik: engleski). Pristupljeno 20. 9. 2021.

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