NLRC5

NLRC5
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2MJM
Identifikatori
Aliasi	NLRC5
Vanjski ID-jevi	OMIM: 613537 MGI: 3612191 HomoloGene: 88935 GeneCards: NLRC5
Lokacija gena (čovjek)
Hrom.	Hromosom 16 (čovjek)
Kraj	57,083,531 bp
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	95,253,900 bp
Ontologija gena
Molekularna funkcija	• nucleotide binding; • GO:0001948, GO:0016582 vezivanje za proteine; • ATP binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Ćelijska komponenta	• citoplazma; • centrosom; • jedro; • citosol;
Biološki proces	• positive regulation of type I interferon-mediated signaling pathway; • negative regulation of type I interferon production; • positive regulation of interferon-gamma-mediated signaling pathway; • positive regulation of MHC class I biosynthetic process; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • regulation of kinase activity; • immune system process; • Urođeni imunski sistem; • negative regulation of NF-kappaB transcription factor activity; • negative regulation of type I interferon-mediated signaling pathway; • response to bacterium; • GO:0007243 intracellular signal transduction;
	Izvori:Amigo / QuickGO
Ortolozi
	84166
	434341
	ENSG00000140853
	ENSMUSG00000074151
	Q86WI3
	C3VPR6
	NM_032206; NM_001330552
	NM_001033207
	NP_001317481; NP_115582
	NP_001028379
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

NLRC5, skraćeno od NOD-liki receptor poreodice CARD domena sa proteinom 5, je unutarćelijski protein koji ima ulogu u imunskom sistemu. NLRC5 je receptor prepoznavanja uzoraka uključen u urođeni imunski sistem na viruse, potencijalno regulacijom aktivnosti interferona. To jest protein koji je kod ljudi kodiran genom sa q kraka hromosoma 16.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1 866 aminokiselina, a molekulska težina 204.595 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MDPVGLQLGN	KNLWSCLVRL	LTKDPEWLNA	KMKFFLPNTD	LDSRNETLDP
EQRVILQLNK	LHVQGSDTWQ	SFIHCVCMQL	EVPLDLEVLL	LSTFGYDDGF
TSQLGAEGKS	QPESQLHHGL	KRPHQSCGSS	PRRKQCKKQQ	LELAKKYLQL
LRTSAQQRYR	SQIPGSGQPH	AFHQVYVPPI	LRRATASLDT	PEGAIMGDVK
VEDGADVSIS	DLFNTRVNKG	PRVTVLLGKA	GMGKTTLAHR	LCQKWAEGHL
NCFQALFLFE	FRQLNLITRF	LTPSELLFDL	YLSPESDHDT	VFQYLEKNAD
QVLLIFDGLD	EALQPMGPDG	PGPVLTLFSH	LCNGTLLPGC	RVMATSRPGK
LPACLPAEAA	MVHMLGFDGP	RVEEYVNHFF	SAQPSREGAL	VELQTNGRLR
SLCAVPALCQ	VACLCLHHLL	PDHAPGQSVA	LLPNMTQLYM	QMVLALSPPG
HLPTSSLLDL	GEVALRGLET	GKVIFYAKDI	APPLIAFGAT	HSLLTSFCVC
TGPGHQQTGY	AFTHLSLQEF	LAALHLMASP	KVNKDTLTQY	VTLHSRWVQR
TKARLGLSDH	LPTFLAGLAS	CTCRPFLSHL	AQGNEDCVGA	KQAAVVQVLK
KLATRKLTGP	KVVELCHCVD	ETQEPELASL	TAQSLPYQLP	FHNFPLTCTD
LATLTNILEH	REAPIHLDFD	GCPLEPHCPE	ALVGCGQIEN	LSFKSRKCGD
AFAEALSRSL	PTMGRLQMLG	LAGSKITARG	ISHLVKALPL	CPQLKEVSFR
DNQLSDQVVL	NIVEVLPHLP	RLRKLDLSSN	SICVSTLLCL	ARVAVTCPTV
RMLQAREADL	IFLLSPPTET	TAELQRAPDL	QESDGQRKGA	QSRSLTLRLQ
KCQLQVHDAE	ALIALLQEGP	HLEEVDLSGN	QLEDEGCRLM	AEAASQLHIA
RKLDLSNNGL	SVAGVHCVLR	AVSACWTLAE	LHISLQHKTV	IFMFAQEPEE
QKGPQERAAF	LDSLMLQMPS	ELPLSSRRMR	LTHCGLQEKH	LEQLCKALGG
SCHLGHLHLD	FSGNALGDEG	AARLAQLLPG	LGALQSLNLS	ENGLSLDAVL
GLVRCFSTLQ	WLFRLDISFE	SQHILLRGDK	TSRDMWATGS	LPDFPAAAKF
LGFRQRCIPR	SLCLSECPLE	PPSLTRLCAT	LKDCPGPLEL	QLSCEFLSDQ
SLETLLDCLP	QLPQLSLLQL	SQTGLSPKSP	FLLANTLSLC	PRVKKVDLRS
LHHATLHFRS	NEEEEGVCCG	RFTGCSLSQE	HVESLCWLLS	KCKDLSQVDL
SANLLGDSGL	RCLLECLPQV	PISGLLDLSH	NSISQESALY	LLETLPSCPR
VREASVNLGS	EQSFRIHFSR	EDQAGKTLRL	SECSFRPEHV	SRLATGLSKS
LQLTELTLTQ	CCLGQKQLAI	LLSLVGRPAG	LFSLRVQEPW	ADRARVLSLL
EVCAQASGSV	TEISISETQQ	QLCVQLEFPR	QEENPEAVAL	RLAHCDLGAH
HSLLVGQLME	TCARLQQLSL	SQVNLCEDDD	ASSLLLQSLL	LSLSELKTFR
LTSSCVSTEG	LAHLASGLGH	CHHLEELDLS	NNQFDEEGTK	ALMRALEGKW
MLKRLDLSHL	LLNSSTLALL	THRLSQMTCL	QSLRLNRNSI	GDVGCCHLSE
ALRAATSLEE	LDLSHNQIGD	AGVQHLATIL	PGLPELRKID	LSGNSISSAG
GVQLAESLVL	CRRLEELMLG	CNALGDPTAL	GLAQELPQHL	RVLHLPFSHL
GPGGALSLAQ	ALDGSPHLEE	ISLAENNLAG	GVLRFCMELP	LLRQIDLVSC
KIDNQTAKLL	TSSFTSCPAL	EVILLSWNLL	GDEAAAELAQ	VLPQMGRLKR
VDLEKNQITA	LGAWLLAEGL	AQGSSIQVIR	LWNNPIPCDM	AQHLKSQEPR
LDFAFFDNQP	QAPWGT

Funkcija

Nedavno je sugerisano da NLRC5 ima pozitivnu ulogu u regulaciji ekspresije molekula MHC klase I glavnog komleksa iistokompatibilnosti (MHCI).^[8] Ovaj aspekt funkcije NLRC5 dalje je istražen uz pomoć Nlrc5-deficitarnih miševa, koji je pokazao smanjenu ekspresiju MHCI u limfocitima (posebno T, NK i NKT limfocitima).^[9] U limfocitima, NLRC5 se nalazi u na jedru i pokreće ekspresiju gena MHCI, zauzimanjem H-2D i H-2K genskih promotora.^[9]

Kod ljudi, NLRC5 protein je kodiran "NLRC5" genom.^[10] Također je nazvan i kao NOD27, NOD4 i CLR16.1.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140853 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074151 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Neerincx A, Lautz K, Menning M, et al. (juni 2010). "A Role for the Human Nucleotide-binding Domain, Leucine-rich Repeat-containing Family Member NLRC5 in Antiviral Responses". J Biol Chem. 285 (34): 26223–32. doi:10.1074/jbc.M110.109736. PMC 2924034. PMID 20538593.
^ ^a ^b Cui J, Zhu L, Xia X, et al. (april 2010). "NLRC5 negatively regulates the NF-κB and type I interferon signaling pathways and antiviral immunity". Cell. 141 (3): 483–96. doi:10.1016/j.cell.2010.03.040. PMC 3150216. PMID 20434986.
^ Kuenzel S, Till A, Winkler M, et al. (februar 2010). "The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses". J. Immunol. 184 (4): 1990–2000. doi:10.4049/jimmunol.0900557. PMID 20061403.
^ Meissner, TB; Li, A; Biswas, A; Lee, K; Liu, Y; Bayir, E; Iliopoulos, D; van den Elsen, PJ; Kobayashi, KS (august 2010). "NLR family member NLRC5 is a transcriptional regulator of MHC class I genes". Proc. Natl. Acad. Sci. 107 (31): 13794–13799. Bibcode:2010PNAS..10713794M. doi:10.1073/pnas.1008684107. PMC 2922274. PMID 20639463.
^ ^a ^b Staehli, F; Ludigs, K; Heinz, LX; Seguín-Estévez, Q; Ferrero, I; Braun, M; Schroder, K; Rebsamen, M; Tardivel, A; Mattmann, C; MacDonald, HR; Romero, P; Reith, W; Guarda, G; Tschopp, J (april 2012). "NLRC5 Deficiency Selectively Impairs MHC Class I-Dependent Lymphocyte Killing by Cytotoxic T Cells". J Immunol. 188 (8): 3820–8. doi:10.4049/jimmunol.1102671. PMID 22412192. Pristupljeno 23. 3. 2012.
^ Dowds TA, Masumoto J, Chen FF, Ogura Y, Inohara N, Núñez G (mart 2003). "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product". Biochem. Biophys. Res. Commun. 302 (3): 575–80. doi:10.1016/S0006-291X(03)00221-3. PMID 12615073.

Šablon:NOD-liki receptoi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140853 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074151 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid20538593-5] Neerincx A, Lautz K, Menning M, et al. (juni 2010). "A Role for the Human Nucleotide-binding Domain, Leucine-rich Repeat-containing Family Member NLRC5 in Antiviral Responses". J Biol Chem. 285 (34): 26223–32. doi:10.1074/jbc.M110.109736. PMC 2924034. PMID 20538593.

[pmid20434986-6] Cui J, Zhu L, Xia X, et al. (april 2010). "NLRC5 negatively regulates the NF-κB and type I interferon signaling pathways and antiviral immunity". Cell. 141 (3): 483–96. doi:10.1016/j.cell.2010.03.040. PMC 3150216. PMID 20434986.

[pmid20061403-7] Kuenzel S, Till A, Winkler M, et al. (februar 2010). "The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses". J. Immunol. 184 (4): 1990–2000. doi:10.4049/jimmunol.0900557. PMID 20061403.

[pmid20639463-8] Meissner, TB; Li, A; Biswas, A; Lee, K; Liu, Y; Bayir, E; Iliopoulos, D; van den Elsen, PJ; Kobayashi, KS (august 2010). "NLR family member NLRC5 is a transcriptional regulator of MHC class I genes". Proc. Natl. Acad. Sci. 107 (31): 13794–13799. Bibcode:2010PNAS..10713794M. doi:10.1073/pnas.1008684107. PMC 2922274. PMID 20639463.

[pmid22412192-9] Staehli, F; Ludigs, K; Heinz, LX; Seguín-Estévez, Q; Ferrero, I; Braun, M; Schroder, K; Rebsamen, M; Tardivel, A; Mattmann, C; MacDonald, HR; Romero, P; Reith, W; Guarda, G; Tschopp, J (april 2012). "NLRC5 Deficiency Selectively Impairs MHC Class I-Dependent Lymphocyte Killing by Cytotoxic T Cells". J Immunol. 188 (8): 3820–8. doi:10.4049/jimmunol.1102671. PMID 22412192. Pristupljeno 23. 3. 2012.

[pmid12615073-10] Dowds TA, Masumoto J, Chen FF, Ogura Y, Inohara N, Núñez G (mart 2003). "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product". Biochem. Biophys. Res. Commun. 302 (3): 575–80. doi:10.1016/S0006-291X(03)00221-3. PMID 12615073.

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