MAPK12

MAPK12
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1CM8, 4QUM
Identifikatori
Aliasi	MAPK12
Vanjski ID-jevi	OMIM: 602399 MGI: 1353438 HomoloGene: 55705 GeneCards: MAPK12
Lokacija gena (čovjek) Hrom. Hromosom 22 (čovjek) Bend 22q13.33 Početak 50,245,450 bp Kraj 50,261,716 bp
Lokacija gena (miš) Hrom. Hromosom 15 (miš) Bend 15|15 E3 Početak 89,014,787 bp Kraj 89,024,906 bp
Ontologija gena Molekularna funkcija • aktivnost sa transferazom • protein kinase activity • nucleotide binding • vezivanje iona metala • kinase activity • GO:0001948, GO:0016582 vezivanje za proteine • ATP binding • magnesium ion binding • protein serine/threonine kinase activity • MAP kinase activity Ćelijska komponenta • citosol • mitohondrija • nukleoplazma • jedro • citoplazma Biološki proces • GO:0009373 regulation of transcription, DNA-templated • Fosforilacija • positive regulation of muscle cell differentiation • muscle organ development • negative regulation of cell cycle • transcription, DNA-templated • positive regulation of peptidase activity • protein phosphorylation • GO:0035404 peptidyl-serine phosphorylation • DNA damage induced protein phosphorylation • ćelijski ciklus • myoblast differentiation • GO:0072468 Transdukcija signala • MAPK cascade • Regulacija ekspresije gena • GO:0007243 intracellular signal transduction • cellular response to organic substance Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	6300	29857
Ensembl	ENSG00000188130	ENSMUSG00000022610
UniProt	P53778	O08911
RefSeq (mRNK)	NM_002969 NM_001303252	NM_013871
RefSeq (bjelančevina)	NP_001290181 NP_002960	NP_038899 NP_001389948 NP_001389949 NP_001389950 NP_001389951
Lokacija (UCSC)	Chr 22: 50.25 – 50.26 Mb	Chr 15: 89.01 – 89.02 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Mitogen-aktivirana protein-kinaza 12 (MAP-kinaza 12), znana i kao vanćeliskim signalom regulirana kinaza 6 (ERK6) ili stresno aktivirana protein kinaza 3 (SAPK3), jest enzim koji je kod ljudi kodiran genom MAPK12 sa hromosoma 22.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 367 aminokiselina, a molekulska težina 41.940 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSSPPPARSG		FYRQEVTKTA		WEVRAVYRDL		QPVGSGAYGA		VCSAVDGRTG
AKVAIKKLYR		PFQSELFAKR		AYRELRLLKH		MRHENVIGLL		DVFTPDETLD
DFTDFYLVMP		FMGTDLGKLM		KHEKLGEDRI		QFLVYQMLKG		LRYIHAAGII
HRDLKPGNLA		VNEDCELKIL		DFGLARQADS		EMTGYVVTRW		YRAPEVILNW
MRYTQTVDIW		SVGCIMAEMI		TGKTLFKGSD		HLDQLKEIMK		VTGTPPAEFV
QRLQSDEAKN		YMKGLPELEK		KDFASILTNA		SPLAVNLLEK		MLVLDAEQRV
TAGEALAHPY		FESLHDTEDE		PQVQKYDDSF		DDVDRTLDEW		KRVTYKEVLS
FKPPRQLGAR		VSKETPL

Funkcija

Aktivacija članova porodice mitogen-aktiviranih protein kinaza je glavni mehanizam za transdukciju vanćelijskih signala. Proteinske kinaze aktivirane stresom su jedna potklasa MAP-kinaza. Protein kodiran ovim genom funkcionira kao pretvarač signala tokom diferencijacije mioblasta u miotube.

Dopunska literatura

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Vanjski linkovi

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.