HLA-DPB1
DP(W2) beta lanac HLA klase II antigena histokompatibilnosti jest protein koji je kod ljudi kodiran genom HLA-DPB1 sa hromosoma 6.[3]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 258 aminokiselina, a molekulska težina 29.159 Da.[4]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MMVLQVSAAP | RTVALTALLM | VLLTSVVQGR | ATPENYLFQG | RQECYAFNGT | ||||
QRFLERYIYN | REEFARFDSD | VGEFRAVTEL | GRPAAEYWNS | QKDILEEKRA | ||||
VPDRMCRHNY | ELGGPMTLQR | RVQPRVNVSP | SKKGPLQHHN | LLVCHVTDFY | ||||
PGSIQVRWFL | NGQEETAGVV | STNLIRNGDW | TFQILVMLEM | TPQQGDVYTC | ||||
QVEHTSLDSP | VTVEWKAQSD | SARSKTLTGA | GGFVLGLIIC | GVGIFMHRRS | ||||
KKVQRGSA |
Funkcija
[uredi | uredi izvor]HLA-DPB pripada paralozima beta lanca HLA klase II. Ova molekula klase II je heterodimer koji se sastoji od alfa (DPA) i beta lanca (DPB), oba usidrena u membrani. Ima centralnu ulogu u imunskom sistemu prezentirajući peptide izvedene iz vanćelijskih proteina. Molekule klase II eksprimiraju se u antigen-prezentirajučim ćelijama (APC: B-limfociti, dendritske ćelije, makrofagi). Beta-lanac je otprilike vlik 26-28 kDa i njegov gen sadrži šest egzona. Egzon 1 kodira vodeći peptid, egzoni 2 i 3 kodiraju dva vanćelijska domena, egzon 4 kodira transmembranski domen, a egzon 5 kodira citoplazmatski rep. Unutar DP molekula i alfa lanac i beta lanac sadrže polimorfizme koji određuju specifičnosti vezivanja peptida, što rezultira u do četiri različite molekule.[4]
Također pogledajte
[uredi | uredi izvor]Reference
[uredi | uredi izvor]- ^ a b c ENSG00000230708, ENSG00000229295, ENSG00000226826, ENSG00000215048, ENSG00000223865, ENSG00000230763, ENSG00000237710 GRCh38: Ensembl release 89: ENSG00000236693, ENSG00000230708, ENSG00000229295, ENSG00000226826, ENSG00000215048, ENSG00000223865, ENSG00000230763, ENSG00000237710 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: HLA-DPB1 major histocompatibility complex, class II, DP beta 1".
- ^ a b "UniProt, P04440" (jezik: engleski). Pristupljeno 6. 9. 2017.
Dopunska literatura
[uredi | uredi izvor]- Mitsunaga S, Kuwata S, Tokunaga K, et al. (1992). "Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two "new" alleles". Hum. Immunol. 34 (3): 203–11. doi:10.1016/0198-8859(92)90113-2. PMID 1358867.
- Marsh SG, Bodmer JG (1993). "HLA class II nucleotide sequences, 1992". Tissue Antigens. 40 (5): 229–43. doi:10.1111/j.1399-0039.1992.tb02050.x. PMID 1362295.
- Eiermann TH, Uhl S, Fakler J, Goldmann SF (1992). "A novel HLA-DPB1 sequence, DPB1*2301". Tissue Antigens. 40 (2): 108–10. doi:10.1111/j.1399-0039.1992.tb01969.x. PMID 1412416.
- Korioth F, Hartung K, Deicher H, Frey J (1992). "A new HLA-DPB1 allele from a patient with systemic lupus erythematosus". Tissue Antigens. 39 (4): 216–9. doi:10.1111/j.1399-0039.1992.tb01938.x. PMID 1529429.
- de Koster HS, Kenter MJ, D'Amaro J, et al. (1991). "Positive correlation between oligonucleotide typing and T-cell recognition of HLA-DP molecules". Immunogenetics. 34 (1): 12–22. doi:10.1007/BF00212307. PMID 1713190. S2CID 21845822.
- Vanderbeeken YE, Duchateau J, Colle H, et al. (1991). "Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated lymphocytes". Arch. Gynecol. Obstet. 248 (4): 199–209. doi:10.1007/BF02390359. PMID 1832848. S2CID 25184115.
- Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507.
- Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): 526–31. PMID 1967269.
- Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. doi:10.1073/pnas.87.22.9052. PMC 55099. PMID 1978941.
- Bugawan TL, Begovich AB, Erlich HA (1990). "Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes". Immunogenetics. 32 (4): 231–41. doi:10.1007/BF00187094. PMID 2242906. S2CID 39873046.
- Lair B, Alber C, Yu WY, et al. (1988). "A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity". J. Immunol. 141 (4): 1353–7. PMID 2456351.
- Bugawan TL, Horn GT, Long CM, et al. (1988). "Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci". J. Immunol. 141 (11): 4024–30. PMID 2460556.
- Begovich AB, Bugawan TL, Nepom BS, et al. (1990). "A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis". Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9489–93. doi:10.1073/pnas.86.23.9489. PMC 298522. PMID 2512583.
- Scholl P, Diez A, Mourad W, et al. (1989). "Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules". Proc. Natl. Acad. Sci. U.S.A. 86 (11): 4210–4. doi:10.1073/pnas.86.11.4210. PMC 287420. PMID 2542966.
- Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding". Nature. 339 (6225): 548–51. doi:10.1038/339548a0. PMID 2543930. S2CID 4246781.
- Lee JS, Sartoris S, Briata P, et al. (1989). "Sequence polymorphism of HLA-DP beta chains". Immunogenetics. 29 (5): 346–9. doi:10.1007/BF00352845. PMID 2714855. S2CID 13414587.
- Compagnone-Post P, Turco E, Robinson C, Trucco M (1988). "The beta-chains of DP4 molecules from different haplotypes are encoded by the same gene". Genomics. 2 (1): 8–13. doi:10.1016/0888-7543(88)90103-6. PMID 2838415.
- Diamond DC, Sleckman BP, Gregory T, et al. (1988). "Inhibition of CD4 T cell function by the HIV envelope protein, gp120". J. Immunol. 141 (11): 3715–7. PMID 2846691.
- Ando A, Inoko H, Kimura M, et al. (1987). "Isolation and allelic polymorphism of cDNA clones and genomic clones of HLA-DP heavy and light chains". Hum. Immunol. 17 (3): 355–67. doi:10.1016/0198-8859(86)90286-7. PMID 2878910.
- Kelly A, Trowsdale J (1985). "Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes". Nucleic Acids Res. 13 (5): 1607–21. doi:10.1093/nar/13.5.1607. PMC 341099. PMID 2987832.