FGFRL1

FGFRL1
Identifikatori
Aliasi	FGFRL1
Vanjski ID-jevi	OMIM: 605830 MGI: 2150920 HomoloGene: 11067 GeneCards: FGFRL1
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	1,026,898 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	108,854,790 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• fibroblast growth factor binding; • heparin binding; • fibroblast growth factor-activated receptor activity;
Ćelijska komponenta	• integral component of membrane; • Golđijev aparat; • transport vesicle; • cell-cell contact zone; • membrana; • ćelijska membrana;
Biološki proces	• skeletal system development; • ventricular septum morphogenesis; • cell-cell adhesion via plasma-membrane adhesion molecules; • substrate adhesion-dependent cell spreading; • protein homooligomerization; • heart valve morphogenesis; • protein heterooligomerization; • diaphragm development; • negative regulation of cell population proliferation; • fibroblast growth factor receptor signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	53834
	116701
	ENSG00000127418
	ENSMUSG00000008090
	Q8N441
	Q91V87
	NM_001004356; NM_001004358; NM_021923; NM_001370296; NM_017862
	NM_001164259; NM_054071
	NP_001004356; NP_001004358; NP_068742; NP_001357225; NP_001004356.1
	NP_001157731; NP_473412
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Receptoliki fibroblastni faktor rasta 1 jest protein koji je kod ljudi kodiran genom sa hromosoma 4.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 504 aminokiselina, а molekulska težina 54.537 Da.^[6].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MTPSPLLLLL	LPPLLLGAFP	PAAAARGPPK	MADKVVPRQV	ARLGRTVRLQ
CPVEGDPPPL	TMWTKDGRTI	HSGWSRFRVL	PQGLKVKQVE	REDAGVYVCK
ATNGFGSLSV	NYTLVVLDDI	SPGKESLGPD	SSSGGQEDPA	SQQWARPRFT
QPSKMRRRVI	ARPVGSSVRL	KCVASGHPRP	DITWMKDDQA	LTRPEAAEPR
KKKWTLSLKN	LRPEDSGKYT	CRVSNRAGAI	NATYKVDVIQ	RTRSKPVLTG
THPVNTTVDF	GGTTSFQCKV	RSDVKPVIQW	LKRVEYGAEG	RHNSTIDVGG
QKFVVLPTGD	VWSRPDGSYL	NKLLITRARQ	DDAGMYICLG	ANTMGYSFRS
AFLTVLPDPK	PPGPPVASSS	SATSLPWPVV	IGIPAGAVFI	LGTLLLWLCQ
AQKKPCTPAP	APPLPGHRPP	GTARDRSGDK	DLPSLAALSA	GPGVGLCEEH
GSPAAPQHLL	GPGPVAGPKL	YPKLYTDIHT	HTHTHSHTHS	HVEGKVHQHI
HYQC

Funkcija

Protein kodiran ovim genom je član porodice receptor faktora rasta fibroblasta (FGFR), gdje je sekvenca aminokiselina visoko konzervirana između članova i tokom evolucije. Članovi porodice FGFR razlikuju se međusobno po afinitetima liganda i tkivnoj distribuciji. Reprezentativni protein pune dužine sastojao bi se od vanćelijskog regiona, sastavljenog od tri domena slična imunoglobulinu, jednog hidrofobnog segmenta koji pokriva membranu i domena citoplazmatske tirozin-kinaze. Vanćelijski dio proteina stupa u interakciju s faktorima rasta fibroblasta, pokrećući kaskadu nizvodnih signala, na kraju utičući na mitogenezu i diferencijaciju. Značajna razlika između ovog genskog proizvoda i ostalih članova porodice je nedostatak domena citoplazmatske tirozin-kinaze. Rezultat je transmembranski receptor koji može stupiti u interakciju s drugim članovima porodice i potencijalno inhibirati signalizaciju. Za ovaj gen pronađene su višestruke alternativno prerađene varijante transkripta koje kodiraju istu izoformu.^[5]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127418 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008090 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: FGFRL1 fibroblast growth factor receptor-like 1".
^ "UniProt, Q8N441" (jezik: engleski). Pristupljeno 28. 10. 2021.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wiedemann M, Trueb B (2001). "Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors". Genomics. 69 (2): 275–279. doi:10.1006/geno.2000.6332. PMID 11031111.
Kim I, Moon S, Yu K, et al. (2001). "A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas(1)". Biochim. Biophys. Acta. 1518 (1–2): 152–6. doi:10.1016/s0167-4781(00)00282-7. PMID 11267671.
Sleeman M, Fraser J, McDonald M, et al. (2001). "Identification of a new fibroblast growth factor receptor, FGFR5". Gene. 271 (2): 171–182. doi:10.1016/S0378-1119(01)00518-2. PMID 11418238.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Trueb B, Zhuang L, Taeschler S, Wiedemann M (2003). "Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues". J. Biol. Chem. 278 (36): 33857–33865. doi:10.1074/jbc.M300281200. PMID 12813049.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Antoine M, Wirz W, Tag CG, et al. (2005). "Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells". Growth Factors. 23 (2): 87–95. doi:10.1080/08977190500096004. PMID 16019430. S2CID 27380246.
Schild C, Trueb B (2006). "Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors". Int. J. Mol. Med. 16 (6): 1169–73. doi:10.3892/ijmm.16.6.1169. PMID 16273302.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127418 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008090 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FGFRL1 fibroblast growth factor receptor-like 1".

[UniProt-6] "UniProt, Q8N441" (jezik: engleski). Pristupljeno 28. 10. 2021.

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