Racemaza

Epimeraze i racemaze – u biohemiji – su izomerazni enzimi koji kataliziraju inverziju stereohemijskih oblika bioloških molekula.^[1]

Racemaza katalizira stereohemijsku inverziju oko asimetričnog ugljikovog atoma u supstratu , a ima samojedan centar simetrije.

Epimeraza katalizira stereohmijsku inverziju konfiguracije oko jednog asimetričnog ugljika u supstratu. Ima više od jednog centra asimetrije, čime interkonvertira epimere.

Epimeraze čovjeka uključuju metilmalonil-CoA epimerazu, koja učestvuje u razlaganju aminokiselina: alanina, izoleucina, metionina i valina^[2], te UDP-glukoza epimerazu, koja djeluje u finalnom koraku is metabolizma galaktoze – katalizirajući reverzibilno pretvaranje UDP-galaktoze u UDP-glukozu.^[3]^[4]^[5] ^[6]^[7]^[8]

Također pogledajte

Reference

^ Tanner M. E. (2002): Understanding nature's strategies for enzyme-catalyzed racemization and epimerization, Acc. Chem. Res., 35 (4): 237–246| pmid = 11955052 | doi = 10.1021/ar000056y.
^ http://www.britannica.com/science/isomerase
^ Lindhorst T. (2007): Essentials of carbohydrate chemistry and biochemistry. Wiley-VCH, 3527315284}}
^ Robyt F. (1997): Essentials of carbohydrate chemistry. Springer, ISBN 0387949518.
^ Laidler K. J. (1978): Physical chemistry with biological applications. Benjamin/Cummings, Menlo Park, ISBN 0-8053-5680-0.
^ Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.
^ Hunter G. K. (2000): Vital Forces. The discovery of the molecular basis of life. Academic Press, London 2000, ISBN 0-12-361811-8.
^ Nelson D. L., Cox M. M. (2013): Lehninger principles of biochemistry. W. H. Freeman and Co., ISBN 978-1-4641-0962-1.

Vanjski linkovi

http://medical-dictionary.thefreedictionary.com/racemase
http://medical-dictionary.thefreedictionary.com/epimerase
Entry Term Epimerases na US National Library of Medicine Medical Subject Headings (MeSH)

[1] Tanner M. E. (2002): Understanding nature's strategies for enzyme-catalyzed racemization and epimerization, Acc. Chem. Res., 35 (4): 237–246| pmid = 11955052 | doi = 10.1021/ar000056y.

[2] ttp://www.britannica.com/science/isomerase

[3] Lindhorst T. (2007): Essentials of carbohydrate chemistry and biochemistry. Wiley-VCH, 3527315284}}

[4] Robyt F. (1997): Essentials of carbohydrate chemistry. Springer, ISBN 0387949518.

[5] Laidler K. J. (1978): Physical chemistry with biological applications. Benjamin/Cummings, Menlo Park, ISBN 0-8053-5680-0.

[6] Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.

[7] Hunter G. K. (2000): Vital Forces. The discovery of the molecular basis of life. Academic Press, London 2000, ISBN 0-12-361811-8.

[8] Nelson D. L., Cox M. M. (2013): Lehninger principles of biochemistry. W. H. Freeman and Co., ISBN 978-1-4641-0962-1.

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