ETV5

Pretraga za
Strukture	Swiss-model
Domene	InterPro

ETS varijanta gena 5
(ETS-srodna molekula)
ETS varijanta gena 5 ; (ETS-srodna molekula)
Identifikatori
Simbol	ETV5
Alt. simboli	ERM
NCBI gen	2119
HGNC	3494
OMIM	601600
RefSeq	NM_004454
UniProt	P41161
Ostali podaci
Lokus	Hrom. 3 q28
Strukture
Pretraga za
Strukture	Swiss-model
Domene	InterPro

ETV5
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4UNO
Identifikatori
Aliasi	ETV5
Vanjski ID-jevi	OMIM: 601600 MGI: 1096867 HomoloGene: 3276 GeneCards: ETV5
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	186,110,318 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	22,258,469 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001948, GO:0016582 vezivanje za proteine; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• nukleoplazma; • jedro; • ćelijska membrana;
Biološki proces	• Ćelijska diferencijacija; • GO:0009373 regulation of transcription, DNA-templated; • locomotory behavior; • regulation of branching involved in mammary gland duct morphogenesis; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • neuromuscular synaptic transmission; • male germ-line stem cell asymmetric division; • positive regulation of neuron differentiation; • skeletal muscle acetylcholine-gated channel clustering; • cellular response to oxidative stress; • positive regulation of glial cell proliferation; • GO:1904739 regulation of synapse organization; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1950094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	2119
	104156
	ENSG00000244405
	ENSMUSG00000013089
	P41161
	Q9CXC9
	NM_004454
	NM_023794; NM_001358428
	NP_004445
	NP_076283; NP_001345357
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Ets varijanta transkripcijskog faktora 5 (ETV5) (također pod nazivom ERM transkripcijski faktor) je transkripcijski faktor koji je kod ljudi kodiran gen om ETV5 sa hromosoma 3.^[5] Generteaju ga Sertolijeve ćelije, koje se nalaze u sjemenicima i imaju ključnu ulogu u spermatogenezi. Njegov ortolog je povezan i sa gojaznošću i bipolarnim poremećajem.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 510 aminokiselina, а molekulska težina 57.838 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MDGFYDQQVP	FMVPGKSRSE	ECRGRPVIDR	KRKFLDTDLA	HDSEELFQDL
SQLQEAWLAE	AQVPDDEQFV	PDFQSDNLVL	HAPPPTKIKR	ELHSPSSELS
SCSHEQALGA	NYGEKCLYNY	CAYDRKPPSG	FKPLTPPTTP	LSPTHQNPLF
PPPQATLPTS	GHAPAAGPVQ	GVGPAPAPHS	LPEPGPQQQT	FAVPRPPHQP
LQMPKMMPEN	QYPSEQRFQR	QLSEPCHPFP	PQPGVPGDNR	PSYHRQMSEP
IVPAAPPPPQ	GFKQEYHDPL	YEHGVPGMPG	PPAHGFQSPM	GIKQEPRDYC
VDSEVPNCQS	SYMRGGYFSS	SHEGFSYEKD	PRLYFDDTCV	VPERLEGKVK
QEPTMYREGP	PYQRRGSLQL	WQFLVTLLDD	PANAHFIAWT	GRGMEFKLIE
PEEVARRWGI	QKNRPAMNYD	KLSRSLRYYY	EKGIMQKVAG	ERYVYKFVCD
PDALFSMAFP	DNQRPFLKAE	SECHLSEEDT	LPLTHFEDSP	AYLLDMDRCS
SLPYAEGFAY

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000244405 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000013089 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Ets variant 5".
^ Williams MJ, Klockars A, Eriksson A, Voisin S, Dnyansagar R, Wiemerslage L, Kasagiannis A, Akram M, Kheder S, Ambrosi V, Hallqvist E, Fredriksson R, Schiöth HB (juni 2016). "The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder". PLOS Genetics. 12 (6): e1006104. doi:10.1371/journal.pgen.1006104. PMC 4900636. PMID 27280443.
^ "UniProt, P41161" (jezik: engleski). Pristupljeno 7. 11. 2021.

Dopunska literatura

T'sas F, Brenner C, Mauen S, Putmans P, Monté D, Van Lint C, Moser M, Baert JL, de Launoit Y (januar 2005). "Expression of the Ets transcription factor Erm is regulated through a conventional PKC signaling pathway in the Molt4 lymphoblastic cell line". FEBS Letters. 579 (1): 66–70. doi:10.1016/j.febslet.2004.11.052. PMID 15620692. S2CID 25112599.
Brandys MK, van Elburg AA, Loos RJ, Bauer F, Hendriks J, van der Schouw YT, Adan RA (mart 2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 153B (2): 695–9. doi:10.1002/ajmg.b.31026. PMID 19746409. S2CID 45793585.
Colas E, Muinelo-Romay L, Alonso-Alconada L, Llaurado M, Monge M, Barbazan J, Gonzalez M, Schoumacher M, Pedrola N, Ertekin T, Devis L, Ruiz A, Castellvi J, Doll A, Gil-Moreno A, Vazquez-Levin M, Lapyckyj L, Lopez-Lopez R, Robine S, Friederich E, Castro M, Reventos J, Vignjevic D, Abal M (novembar 2012). "ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas". Oncogene. 31 (45): 4778–88. doi:10.1038/onc.2011.632. PMID 22266854.
Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T, Yang Y, Guo Y, Chang C (novembar 2001). "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells". The Journal of Biological Chemistry. 276 (44): 40417–23. doi:10.1074/jbc.M104765200. PMID 11509567.
Korz C, Pscherer A, Benner A, Mertens D, Schaffner C, Leupolt E, Döhner H, Stilgenbauer S, Lichter P (juni 2002). "Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes". Blood. 99 (12): 4554–61. doi:10.1182/blood.V99.12.4554. PMID 12036888.
Chotteau-Lelièvre A, Révillion F, Lhotellier V, Hornez L, Desbiens X, Cabaret V, de Launoit Y, Peyrat JP (novembar 2004). "Prognostic value of ERM gene expression in human primary breast cancers". Clinical Cancer Research. 10 (21): 7297–303. doi:10.1158/1078-0432.CCR-04-0593. PMID 15534105.
Planagumà J, Liljeström M, Alameda F, Bützow R, Virtanen I, Reventós J, Hukkanen M (januar 2011). "Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma". Human Pathology. 42 (1): 57–67. doi:10.1016/j.humpath.2010.01.025. PMID 20970160.
Monge M, Colas E, Doll A, Gil-Moreno A, Castellvi J, Diaz B, Gonzalez M, Lopez-Lopez R, Xercavins J, Carreras R, Alameda F, Canals F, Gabrielli F, Reventos J, Abal M (august 2009). "Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress". Carcinogenesis. 30 (8): 1288–97. doi:10.1093/carcin/bgp119. PMID 19443906.
Ng MC, Tam CH, So WY, Ho JS, Chan AW, Lee HM, Wang Y, Lam VK, Chan JC, Ma RC (maj 2010). "Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese". The Journal of Clinical Endocrinology and Metabolism. 95 (5): 2418–25. doi:10.1210/jc.2009-2077. PMID 20215397.

Vanjski linkovi

ERM protein, human na US National Library of Medicine Medical Subject Headings (MeSH)
ETV5 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000244405 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000013089 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ets variant 5".

[Williams2016-6] Williams MJ, Klockars A, Eriksson A, Voisin S, Dnyansagar R, Wiemerslage L, Kasagiannis A, Akram M, Kheder S, Ambrosi V, Hallqvist E, Fredriksson R, Schiöth HB (juni 2016). "The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder". PLOS Genetics. 12 (6): e1006104. doi:10.1371/journal.pgen.1006104. PMC 4900636. PMID 27280443.

[UniProt-7] "UniProt, P41161" (jezik: engleski). Pristupljeno 7. 11. 2021.

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