EGR2

EGR2
Identifikatori
Aliasi	EGR2
Vanjski ID-jevi	OMIM: 129010 MGI: 95296 HomoloGene: 20123 GeneCards: EGR2
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	62,819,167 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	67,542,188 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • HMG box domain binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • chromatin binding; • vezivanje iona metala; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001948, GO:0016582 vezivanje za proteine; • nucleic acid binding; • ubiquitin protein ligase binding; • aktivnost sa transferazom; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • SUMO ligase activity;
Ćelijska komponenta	• citoplazma; • jedro; • nukleoplazma; • intracellular membrane-bounded organelle;
Biološki proces	• cellular response to organic substance; • rhythmic behavior; • peripheral nervous system development; • GO:0009373 regulation of transcription, DNA-templated; • rhombomere 3 development; • brain segmentation; • transcription by RNA polymerase II; • protein sumoylation; • rhombomere 3 formation; • transcription, DNA-templated; • response to insulin; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • brain development; • rhombomere 5 formation; • protein export from nucleus; • learning or memory; • skeletal muscle cell differentiation; • Schwann cell differentiation; • regulation of neuronal synaptic plasticity; • myelination; • facial nerve structural organization; • regulation of ossification; • motor neuron axon guidance; • fat cell differentiation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1950094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	1959
	13654
	ENSG00000122877
	ENSMUSG00000037868
	P11161
	P08152
	NM_000399; NM_001136177; NM_001136178; NM_001136179; NM_001321037
	NM_010118; NM_001347458
	NP_000390; NP_001129649; NP_001129650; NP_001129651; NP_001307966
NP_001334387; NP_034248; NP_001360912; NP_001360914; NP_001360915;
	NP_001360916
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 2 ranog odgovora na rast je protein koji je kod ljudi kodiran genom EGR2. EGR2 (znan i kao Krox20) je transkripcijski faktor regulacije, sa tri mjesta vezanja DNK cinkovog prsta, izrazito eksprimiran u populaciji migrirajućih ćelija nervnog grebena.^[5]^[6]^[7] Kasnije se eksprimira u neuronskim ćelijama kranijalne ganglije izvedene iz grebena. Protein kodiran pomoću Krox20 sadrži dva cinkova prsta tipa cys2his2. Ekspresija Krox20 gena ograničena je na rani razvoj stražnjeg mozga.^[6]^[8] Evolucijski je konzerviran kod kičmenjaka, uključujuči ljude, miševe, kokoši i zebrice.^[9] Osim toga, aminokiselinska sekvenca i većina aspekata uzorka embrionskog gena konzervirani su kod kičmenjaka, što dodatno implicira njegovu ulogu u razvoju stražnjeg mozga.^[7]^[10]^[11]^[12] Kada se

Krox20 deletira na miševima, sposobnost kodiranja proteina gena Krox20 (uključujući domen vezanja DNK cinkovog prsta) se smanjuje. Ovi miševi ne mogu preživjeti nakon rođenja i pokazuju velike nedostatke stražnjeg mozga.^[6]^[8] Ovi nedostaci uključuju, ali nisu ograničeni na nedostatke u formiranju kranijalnih čulnihih ganglija, djelimičnu fuziju trigeminusog živca (V) s facijalnim (VII) i slušnim (VII) živcima, proksimalni korijeni živaca koji izlaze iz ovih ganglija bili su neorganizirani i isprepleteni jedni s drugima pri ulasku u moždano stablo, a došlo je i do spajanja glosofaringeusog (IX) nervnog kompleksa.^[13]^[14]^[15]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 476 aminokiselina, а molekulska težina 50.302.^[16]

10	20	30	40	50
MMTAKAVDKI	PVTLSGFVHQ	LSDNIYPVED	LAATSVTIFP	NAELGGPFDQ
MNGVAGDGMI	NIDMTGEKRS	LDLPYPSSFA	PVSAPRNQTF	TYMGKFSIDP
QYPGASCYPE	GIINIVSAGI	LQGVTSPAST	TASSSVTSAS	PNPLATGPLG
VCTMSQTQPD	LDHLYSPPPP	PPPYSGCAGD	LYQDPSAFLS	AATTSTSSSL
AYPPPPSYPS	PKPATDPGLF	PMIPDYPGFF	PSQCQRDLHG	TAGPDRKPFP
CPLDTLRVPP	PLTPLSTIRN	FTLGGPSAGV	TGPGASGGSE	GPRLPGSSSA
AAAAAAAAAY	NPHHLPLRPI	LRPRKYPNRP	SKTPVHERPY	PCPAEGCDRR
FSRSDELTRH	IRIHTGHKPF	QCRICMRNFS	RSDHLTTHIR	THTGEKPFAC
DYCGRKFARS	DERKRHTKIH	LRQKERKSSA	PSASVPAPST	ASCSGGVQPG
GTLCSSNSSS	LGGGPLAPCS	SRTRTP

Simboli

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Funkcija

Protein 2 za odgovor na rani rast je transkripcijski faktor s tri tandemska cinkova prsta tipa C2H2. Mutacije u ovom genu povezane su s autosomno dominantnom Charcot-Marie-Toothovom bolesti, tip 1D,^[17] Dejerine–Sottasovom bolesti,^[18] i kongenitalnom hipomijelinacijskom neuropatijom.^[19] Dvije studije povezale su ekspresiju "EGR2" sa proliferacijom osteoprogenitora^[20] i ćelijske linije izvedene iz Ewingovog sarkoma, koji je visoko agresivan rak povezan s kostima.^[21]

Novo istraživanje sugerira da je Krox20 - ili njegov nedostatak – uzrok muške prijezrelosne ćelavosti.^[22]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122877 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037868 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chavrier P, Janssen-Timmen U, Mattéi MG, Zerial M, Bravo R, Charnay P (februar 1989). "Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos". Molecular and Cellular Biology. 9 (2): 787–97. doi:10.1128/mcb.9.2.787. PMC 362656. PMID 2496302.
^ ^a ^b ^c Swiatek PJ, Gridley T (novembar 1993). "Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20". Genes & Development. 7 (11): 2071–84. doi:10.1101/gad.7.11.2071. PMID 8224839.
^ ^a ^b Wilkinson DG, Bhatt S, Chavrier P, Bravo R, Charnay P (februar 1989). "Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse". Nature. 337 (6206): 461–4. Bibcode:1989Natur.337..461W. doi:10.1038/337461a0. PMID 2915691. S2CID 4336310.
^ ^a ^b Bradley LC, Snape A, Bhatt S, Wilkinson DG (januar 1993). "The structure and expression of the Xenopus Krox-20 gene: conserved and divergent patterns of expression in rhombomeres and neural crest". Mechanisms of Development. 40 (1–2): 73–84. doi:10.1016/0925-4773(93)90089-g. PMID 8443108. S2CID 20347966.
^ Bhat RV, Worley PF, Cole AJ, Baraban JM (april 1992). "Activation of the zinc finger encoding gene krox-20 in adult rat brain: comparison with zif268". Brain Research. Molecular Brain Research. 13 (3): 263–6. doi:10.1016/0169-328x(92)90034-9. PMID 1317498.
^ Wilkinson DG, Bhatt S, Cook M, Boncinelli E, Krumlauf R (oktobar 1989). "Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain". Nature. 341 (6241): 405–9. Bibcode:1989Natur.341..405W. doi:10.1038/341405a0. PMID 2571936. S2CID 4324322.
^ Hunt P, Gulisano M, Cook M, Sham MH, Faiella A, Wilkinson D, Boncinelli E, Krumlauf R (oktobar 1991). "A distinct Hox code for the branchial region of the vertebrate head". Nature. 353 (6347): 861–4. Bibcode:1991Natur.353..861H. doi:10.1038/353861a0. PMID 1682814. S2CID 4312466.
^ Oxtoby E, Jowett T (mart 1993). "Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development". Nucleic Acids Research. 21 (5): 1087–95. doi:10.1093/nar/21.5.1087. PMC 309267. PMID 8464695.
^ Frohman MA, Boyle M, Martin GR (oktobar 1990). "Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm". Development. 110 (2): 589–607. doi:10.1242/dev.110.2.589. PMID 1983472.
^ Murphy P, Davidson DR, Hill RE (septembar 1989). "Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain". Nature. 341 (6238): 156–9. Bibcode:1989Natur.341..156M. doi:10.1038/341156a0. PMID 2571087. S2CID 4371764.
^ Nieto MA, Bradley LC, Wilkinson DG (1991). "Conserved segmental expression of Krox-20 in the vertebrate hindbrain and its relationship to lineage restriction". Development. Suppl 2: 59–62. doi:10.1242/dev.113.Supplement_2.59. hdl:10261/32226. PMID 1688180.
^ "UniProt, P11161". Pristupljeno 1. 9. 2021.
^ "Entrez Gene: EGR2 early growth response 2 (Krox-20 homolog, Drosophila)".
^ Boerkoel CF, Takashima H, Bacino CA, Daentl D, Lupski JR (juli 2001). "EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy". Neurogenetics. 3 (3): 153–7. doi:10.1007/s100480100107. PMID 11523566. S2CID 32746701.
^ Warner LE, Mancias P, Butler IJ, McDonald CM, Keppen L, Koob KG, Lupski JR (april 1998). "Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies". Nature Genetics. 18 (4): 382–4. doi:10.1038/ng0498-382. PMID 9537424. S2CID 25550479.
^ Chandra A, Lan S, Zhu J, Siclari VA, Qin L (juli 2013). "Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expression". The Journal of Biological Chemistry (jezik: engleski). 288 (28): 20488–98. doi:10.1074/jbc.M112.447250. PMC 3711314. PMID 23720781.
^ Grünewald TG, Bernard V, Gilardi-Hebenstreit P, Raynal V, Surdez D, Aynaud MM, et al. (septembar 2015). "Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite". Nature Genetics. 47 (9): 1073–8. doi:10.1038/ng.3363. PMC 4591073. PMID 26214589.
^ Le, Lu. "Scientists find skin cells at the root of balding, gray hair". UT Southwestern Medical Center. Pristupljeno 9. 5. 2017.

Dopunska literatura

Rangnekar VM, Aplin AC, Sukhatme VP (maj 1990). "The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein". Nucleic Acids Research. 18 (9): 2749–57. doi:10.1093/nar/18.9.2749. PMC 330760. PMID 2111009.
Chavrier P, Janssen-Timmen U, Mattéi MG, Zerial M, Bravo R, Charnay P (februar 1989). "Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos". Molecular and Cellular Biology. 9 (2): 787–97. doi:10.1128/mcb.9.2.787. PMC 362656. PMID 2496302.
Joseph LJ, Le Beau MM, Jamieson GA, Acharya S, Shows TB, Rowley JD, Sukhatme VP (oktobar 1988). "Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure". Proceedings of the National Academy of Sciences of the United States of America. 85 (19): 7164–8. Bibcode:1988PNAS...85.7164J. doi:10.1073/pnas.85.19.7164. PMC 282144. PMID 3140236.
Topilko P, Schneider-Maunoury S, Levi G, Baron-Van Evercooren A, Chennoufi AB, Seitanidou T, Babinet C, Charnay P (oktobar 1994). "Krox-20 controls myelination in the peripheral nervous system". Nature. 371 (6500): 796–9. Bibcode:1994Natur.371..796T. doi:10.1038/371796a0. PMID 7935840. S2CID 4333028.
Sham MH, Vesque C, Nonchev S, Marshall H, Frain M, Gupta RD, Whiting J, Wilkinson D, Charnay P, Krumlauf R (januar 1993). "The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation". Cell. 72 (2): 183–96. doi:10.1016/0092-8674(93)90659-E. PMID 8093858. S2CID 3205209.
Levi G, Topilko P, Schneider-Maunoury S, Lasagna M, Mantero S, Pesce B, Ghersi G, Cancedda R, Charnay P (juni 1996). "Role of Krox-20 in endochondral bone formation". Annals of the New York Academy of Sciences. 785 (1): 288–91. Bibcode:1996NYASA.785..288L. doi:10.1111/j.1749-6632.1996.tb56286.x. PMID 8702157. S2CID 27761983.
Warner LE, Mancias P, Butler IJ, McDonald CM, Keppen L, Koob KG, Lupski JR (april 1998). "Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies". Nature Genetics. 18 (4): 382–4. doi:10.1038/ng0498-382. PMID 9537424. S2CID 25550479.
Warner LE, Svaren J, Milbrandt J, Lupski JR (juli 1999). "Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies". Human Molecular Genetics. 8 (7): 1245–51. doi:10.1093/hmg/8.7.1245. PMID 10369870.
Timmerman V, De Jonghe P, Ceuterick C, De Vriendt E, Löfgren A, Nelis E, Warner LE, Lupski JR, Martin JJ, Van Broeckhoven C (juni 1999). "Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype". Neurology. 52 (9): 1827–32. doi:10.1212/wnl.52.9.1827. PMID 10371530. S2CID 11569651.
Bellone E, Di Maria E, Soriani S, Varese A, Doria LL, Ajmar F, Mandich P (oktobar 1999). "A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease". Human Mutation. 14 (4): 353–4. doi:10.1002/(SICI)1098-1004(199910)14:4<353::AID-HUMU17>3.0.CO;2-4. PMID 10502832.
Pareyson D, Taroni F, Botti S, Morbin M, Baratta S, Lauria G, Ciano C, Sghirlanzoni A (april 2000). "Cranial nerve involvement in CMT disease type 1 due to early growth response 2 gene mutation". Neurology. 54 (8): 1696–8. doi:10.1212/wnl.54.8.1696. hdl:2434/531868. PMID 10762521. S2CID 28404231.
Gambardella L, Schneider-Maunoury S, Voiculescu O, Charnay P, Barrandon Y (septembar 2000). "Pattern of expression of the transcription factor Krox-20 in mouse hair follicle". Mechanisms of Development. 96 (2): 215–8. doi:10.1016/S0925-4773(00)00398-1. PMID 10960786. S2CID 18000564.
Yoshihara T, Kanda F, Yamamoto M, Ishihara H, Misu K, Hattori N, Chihara K, Sobue G (mart 2001). "A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot--Marie--Tooth disease type 1". Journal of the Neurological Sciences. 184 (2): 149–53. doi:10.1016/S0022-510X(00)00504-9. PMID 11239949. S2CID 19693658.
Boerkoel CF, Takashima H, Bacino CA, Daentl D, Lupski JR (juli 2001). "EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy". Neurogenetics. 3 (3): 153–7. doi:10.1007/s100480100107. PMID 11523566. S2CID 32746701.
Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD (maj 2002). "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". The Journal of Biological Chemistry. 277 (22): 19482–7. doi:10.1074/jbc.M201687200. PMID 11909874.
Vandenberghe N, Upadhyaya M, Gatignol A, Boutrand L, Boucherat M, Chazot G, Vandenberghe A, Latour P (decembar 2002). "Frequency of mutations in the early growth response 2 gene associated with peripheral demyelinating neuropathies". Journal of Medical Genetics. 39 (12): 81e–81. doi:10.1136/jmg.39.12.e81. PMC 1757229. PMID 12471219.
Musso M, Balestra P, Taroni F, Bellone E, Mandich P (februar 2003). "Different consequences of EGR2 mutants on the transactivation of human Cx32 promoter". Neurobiology of Disease. 12 (1): 89–95. doi:10.1016/S0969-9961(02)00018-9. PMID 12609493. S2CID 29600641.
Unoki M, Nakamura Y (april 2003). "EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK". Oncogene. 22 (14): 2172–85. doi:10.1038/sj.onc.1206222. PMID 12687019.
Numakura C, Shirahata E, Yamashita S, Kanai M, Kijima K, Matsuki T, Hayasaka K (juni 2003). "Screening of the early growth response 2 gene in Japanese patients with Charcot-Marie-Tooth disease type 1". Journal of the Neurological Sciences. 210 (1–2): 61–4. doi:10.1016/S0022-510X(03)00028-5. PMID 12736090. S2CID 36723641.

Vanjski linkovi

GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 1
GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 4
EGR2 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122877 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037868 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Chavrier_1989-5] Chavrier P, Janssen-Timmen U, Mattéi MG, Zerial M, Bravo R, Charnay P (februar 1989). "Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos". Molecular and Cellular Biology. 9 (2): 787–97. doi:10.1128/mcb.9.2.787. PMC 362656. PMID 2496302.

[Swiatek_1993-6] Swiatek PJ, Gridley T (novembar 1993). "Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20". Genes & Development. 7 (11): 2071–84. doi:10.1101/gad.7.11.2071. PMID 8224839.

[Wilkinson_1989a-7] Wilkinson DG, Bhatt S, Chavrier P, Bravo R, Charnay P (februar 1989). "Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse". Nature. 337 (6206): 461–4. Bibcode:1989Natur.337..461W. doi:10.1038/337461a0. PMID 2915691. S2CID 4336310.

[Bradley_1993-8] Bradley LC, Snape A, Bhatt S, Wilkinson DG (januar 1993). "The structure and expression of the Xenopus Krox-20 gene: conserved and divergent patterns of expression in rhombomeres and neural crest". Mechanisms of Development. 40 (1–2): 73–84. doi:10.1016/0925-4773(93)90089-g. PMID 8443108. S2CID 20347966.

[Bhat_1992-9] Bhat RV, Worley PF, Cole AJ, Baraban JM (april 1992). "Activation of the zinc finger encoding gene krox-20 in adult rat brain: comparison with zif268". Brain Research. Molecular Brain Research. 13 (3): 263–6. doi:10.1016/0169-328x(92)90034-9. PMID 1317498.

[Wilkinson_1989b-10] Wilkinson DG, Bhatt S, Cook M, Boncinelli E, Krumlauf R (oktobar 1989). "Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain". Nature. 341 (6241): 405–9. Bibcode:1989Natur.341..405W. doi:10.1038/341405a0. PMID 2571936. S2CID 4324322.

[Hunt_1991-11] Hunt P, Gulisano M, Cook M, Sham MH, Faiella A, Wilkinson D, Boncinelli E, Krumlauf R (oktobar 1991). "A distinct Hox code for the branchial region of the vertebrate head". Nature. 353 (6347): 861–4. Bibcode:1991Natur.353..861H. doi:10.1038/353861a0. PMID 1682814. S2CID 4312466.

[Oxtoby_1993-12] Oxtoby E, Jowett T (mart 1993). "Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development". Nucleic Acids Research. 21 (5): 1087–95. doi:10.1093/nar/21.5.1087. PMC 309267. PMID 8464695.

[Frohman_1990-13] Frohman MA, Boyle M, Martin GR (oktobar 1990). "Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm". Development. 110 (2): 589–607. doi:10.1242/dev.110.2.589. PMID 1983472.

[Murphy_1989-14] Murphy P, Davidson DR, Hill RE (septembar 1989). "Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain". Nature. 341 (6238): 156–9. Bibcode:1989Natur.341..156M. doi:10.1038/341156a0. PMID 2571087. S2CID 4371764.

[Nieto_1991-15] Nieto MA, Bradley LC, Wilkinson DG (1991). "Conserved segmental expression of Krox-20 in the vertebrate hindbrain and its relationship to lineage restriction". Development. Suppl 2: 59–62. doi:10.1242/dev.113.Supplement_2.59. hdl:10261/32226. PMID 1688180.

[UniProt-16] "UniProt, P11161". Pristupljeno 1. 9. 2021.

[entrez-17] "Entrez Gene: EGR2 early growth response 2 (Krox-20 homolog, Drosophila)".

[18] Boerkoel CF, Takashima H, Bacino CA, Daentl D, Lupski JR (juli 2001). "EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy". Neurogenetics. 3 (3): 153–7. doi:10.1007/s100480100107. PMID 11523566. S2CID 32746701.

[19] Warner LE, Mancias P, Butler IJ, McDonald CM, Keppen L, Koob KG, Lupski JR (april 1998). "Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies". Nature Genetics. 18 (4): 382–4. doi:10.1038/ng0498-382. PMID 9537424. S2CID 25550479.

[20] Chandra A, Lan S, Zhu J, Siclari VA, Qin L (juli 2013). "Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expression". The Journal of Biological Chemistry (jezik: engleski). 288 (28): 20488–98. doi:10.1074/jbc.M112.447250. PMC 3711314. PMID 23720781.

[21] Grünewald TG, Bernard V, Gilardi-Hebenstreit P, Raynal V, Surdez D, Aynaud MM, et al. (septembar 2015). "Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite". Nature Genetics. 47 (9): 1073–8. doi:10.1038/ng.3363. PMC 4591073. PMID 26214589.

[22] Le, Lu. "Scientists find skin cells at the root of balding, gray hair". UT Southwestern Medical Center. Pristupljeno 9. 5. 2017.

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