ZNF142

ZNF142
Identifikatori
Aliasi	ZNF142
Vanjski ID-jevi	OMIM: 604083 MGI: 1924514 HomoloGene: 3723 GeneCards: ZNF142
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	218,659,655 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	74,627,405 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • vezivanje iona metala; • nucleic acid binding; • molekularna funkcija; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro; • ćelijska komponenta;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0022610 biološki proces; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1950094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	7701
	77264
	ENSG00000115568
	ENSMUSG00000026135
	P52746
	G5E869
NM_001105537; NM_001366287; NM_001366288; NM_001366289; NM_001366290;
	NM_001366291; NM_001367339; NM_001367340; NM_001367341; NM_001367342; NM_001379659; NM_001379660; NM_001379661; NM_001379662
	NM_029888; NM_001310668
NP_001099007; NP_001353216; NP_001353217; NP_001353218; NP_001353219;
	NP_001353220; NP_001354268; NP_001354269; NP_001354270; NP_001354271; NP_001366588; NP_001366589; NP_001366590; NP_001366591
	NP_001297597; NP_084164
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein cinkovog prsta 142 jest protein koji je kod ljudi kodiran genom ZNF142 sa hromosoma 2.^[5]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 1.687 aminokiselina, a molekulska težina 187.880 Da.^[6].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MTDPLLDSQP	ASSTGEMDGL	CPELLLIPPP	LSNRGILGPV	QSPCPSRDPA
PIPTEPGCLL	VEATATEEGP	GNMEIIVETV	AGTLTPGAPG	ETPAPKLPPG
EREPSQEAGT	PLPGQETAEE	ENVEKEEKSD	TQKDSQKAVD	KGQGAQRLEG
DVVSGTESLF	KTHMCPECKR	CFKKRTHLVE	HLHLHFPDPS	LQCPNCQKFF
TSKSKLKTHL	LRELGEKAHH	CPLCHYSAVE	RNALNRHMAS	MHEDISNFYS
DTYACPVCRE	EFRLSQALKE	HLKSHTAAAA	AEPLPLRCFQ	EGCSYAAPDR
KAFIKHLKET	HGVRAVECRH	HSCPMLFATA	EAMEAHHKSH	YAFHCPHCDF
ACSNKHLFRK	HKKQGHPGSE	ELRCTFCPFA	TFNPVAYQDH	VGKMHAHEKI
HQCPECNFAT	AHKRVLIRHM	LLHTGEKPHK	CELCDFTCRD	VSYLSKHMLT
HSNTKDYMCT	ECGYVTKWKH	YLRVHMRKHA	GDLRYQCNQC	SYRCHRADQL
SSHKLRHQGK	SLMCEVCAFA	CKRKYELQKH	MASQHHPGTP	APLYPCHYCS
YQSRHKQAVL	SHENCKHTRL	REFHCALCDY	RTFSNTTLLF	HKRKAHGYVP
GDQAWQLRYA	SQEPEGAMQG	PTPPPDSEPS	NQLSARPEGP	GHEPGTVVDP
SLDQALPEMS	EEVNTGRQEG	SEAPHGGDLG	GSPSPAEVEE	GSCTLHLEAL
GVELESVTEP	PLEEVTETAP	MEFRPLGLEG	PDGLEGPELS	SFEGIGTSDL
SAEENPLLEK	PVSEPSTNPP	SLEEAPNNWV	GTFKTTPPAE	TAPLPPLPES
ESLLKALRRQ	DKEQAEALVL	EGRVQMVVIQ	GEGRAFRCPH	CPFITRREKA
LNLHSRTGCQ	GRREPLLCPE	CGASFKQQRG	LSTHLLKKCP	VLLRKNKGLP
RPDSPIPLQP	VLPGTQASED	TESGKPPPAS	QEAELLLPKD	APLELPREPE
ETEEPLATVS	GSPVPPAGNS	LPTEAPKKHC	FDPVPPAGNS	SPTEAPKKHH
LDPVPPAGNS	SPTEALKKHR	FEQGKFHCNS	CPFLCSRLSS	ITSHVAEGCR
GGRGGGGKRG	TPQTQPDVSP	LSNGDSAPPK	NGSTESSSGD	GDTVLVQKQK
GARFSCPTCP	FSCQQERALR	THQIRGCPLE	ESGELHCSLC	PFTAPAATAL
RLHQKRRHPT	AAPARGPRPH	LQCGDCGFTC	KQSRCMQQHR	RLKHEGVKPH
QCPFCDFSTT	RRYRLEAHQS	RHTGIGRIPC	SSCPQTFGTN	SKLRLHRLRV
HDKTPTHFCP	LCDYSGYLRH	DITRHVNSCH	QGTPAFACSQ	CEAQFSSETA
LKQHALRRHP	EPAQPAPGSP	AETTEGPLHC	SRCGLLCPSP	ASLRGHTRKQ
HPRLECGACQ	EAFPSRLALD	EHRRQQHFSH	RCQLCDFAAR	ERVGLVKHYL
EQHEETSAAV	AASDGDGDAG	QPPLHCPFCD	FTCRHQLVLD	HHVKGHGGTR
LYKCTDCAYS	TKNRQKITWH	SRIHTGEKPY	HCHLCPYACA	DPSRLKYHMR
IHKEERKYLC	PECGYKCKWV	NQLKYHMTKH	TGLKPYQCPE	CEYCTNRADA
LRVHQETRHR	EARAFMCEQC	GKAFKTRFLL	RTHLRKHSEA	KPYVCNVCHR
AFRWAAGLRH	HALTHTDRHP	FFCRLCNYKA	KQKFQVVKHV	RRHHPDQADP
NQGVGKDPTT	PTVHLHDVQL	EDPSPPAPAA	PHTGPEG

Funkcija

Protein kodiran ovim genom pripada Krupelskoj porodici proteina C2H2 tipa cinkovih prstiju. Sadrži 31 cinkov prst tipa C2H2 i može biti uključen u regulaciju transkripcije. Za ovaj gen su pronađene alternativno prerađene varijante transkripta.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115568 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026135 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Zinc finger protein 142". Pristupljeno 30. 1. 2017.
^ "UniProt, P52746" (jezik: engleski). Pristupljeno 17. 11. 2021.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115568 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026135 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Zinc finger protein 142". Pristupljeno 30. 1. 2017.

[UniProt-6] "UniProt, P52746" (jezik: engleski). Pristupljeno 17. 11. 2021.

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