Our NanoOne has been featured in an exciting new Hot Paper in Angewandte Chemie from the brilliant minds of Wanwan Qiu, Xiao-Hua Qin and team! They have developed a photocleavable coumarin-based hydrogel, that can be processed at high efficiency in the presence of cells. For many biologically relevant structures and patterns, a subtractive approach is often superior to the conventional additive approach. Take a look at the paper below for more information. We are always excited to see novel materials being processed with the NanoOne and are very much looking forward to seeing what comes next from this team! Congratulations again to everyone involved. #2PP #Bioprinting #Biomaterials #Hydrogels
💥 [Bone-paper-alert-4] 💥 Congratulations to Wanwan Qiu on her Hot Paper just published in Angewandte Chemie! To advance the applications of two-photon lithography in subtractive biofabrication, we developed coumarin-based photodegradable hydrogels using a Passerini multi-component reaction. Utilizing a commercial NanoOne1000 printing system, these hydrogels enable two-photon subtractive 3D microprinting of complex microfluidic networks at 300 mm s-1 and laser-guided cell outgrowth on demand, paving the way for new bio-applications, such as spatiotemporal tissue engineering. Interestingly, we discovered that hydrogels formed by the long-conjugated coumarin linker are inert under single-photon irradiation but sensitive only to two-photon irradiation. We also demonstrated that laser-guided cell migration in these hydrogels relies on the presence of both biophysical (microchannel) and biochemical (cell adhesive RGD) cues. Paper link: https://lnkd.in/dJ58n3uF Authors: Wanwan Qiu, Christian Gehre, Jaime Pietrantuono Nepomuceno, Yinyin Bao, Zhiquan Li, Ralph Mueller, Xiao-Hua Qin #Swiss National Science Foundation SNSF #ETH Zürich #ETH Zurich Competence Center for Materials and Processes (MaP) #ALIVE #AdvancedEngineeringWithLivingMaterials #MaPDoctoralSchool #MaterialsandProcesses #biomaterials #2PP #microtechnologies #3Dprinting #advancedmanufacturing #innovation #OpenAccess