RCPE - Research Center Pharmaceutical Engineering GmbH

We are excited to share our latest paper in a collaborative effort with MeltPrep and Celanese Our project showcases the capabilities of the MeltPrep VCM Filament Molder, an innovative tool that produces filaments in extremely small quantities (as little as 3 grams) and works with challenging materials, like low-viscosity EVA28 grades, that are difficult to process with traditional horizontal hot melt extrusion. This development expands the material options for fused filament fabrication, granting access to materials that were previously inaccessible due to limitations in producing high-quality printing filaments. Read the full paper here: https://rdcu.be/dVFmd

The countdown to IMRET17 in Graz has begun, with just under four weeks to go! If you're interested in the latest advancements in microreaction technology, this event is a great opportunity to learn and connect. We hope to see you there! For more information, visit: https://imret17.com/

Are you seeking a remarkable opportunity to combine your academic prowess with real-world industry experience? We have fantastic news for you! We're thrilled to offer various possibilities for students to write their master's thesis in close collaboration with our industrial and scientific partners. This unique program provides an extraordinary chance to merge theory and practice while working on and with cutting-edge technology that makes a tangible impact. Find all open positions and more information at https://lnkd.in/d4KaFfs7 #pharmaceuticalmanufacturing #drugdelivery #pharma #pharmaceuticals #students #thesis #studenten

Excited to share our latest publication! Huge congratulations to Christina Glader and co-authors for this amazing work! 🎉 In this research, we tackle a key challenge in drug screening: optimizing the delivery of drugs with poor solubility or permeability, especially when targeting intracellular components. Our study focuses on nanostructured lipid carriers (NLC) and their cellular uptake using high-throughput screening based on acoustic droplet ejection (ADE) technology (Echo liquid handler). Key findings include: 🔹 Surface tension and viscosity of NLC dispersions must be tailored for reliable ADE transfer. 🔹 Automated uptake studies, confirmed by imaging-based and spectral flow cytometry, highlighted the importance of optimizing the matrix composition for cellular uptake. Check out the full publication here: https://lnkd.in/dWqrX9_t CBmed GmbH, RCPE - Research Center Pharmaceutical Engineering GmbH, University of Graz, Medizinische Universität Graz

𝗘𝗖𝗖𝗣𝗠 𝗪𝗔𝗦 𝗔 𝗛𝗨𝗚𝗘 𝗦𝗨𝗖𝗖𝗘𝗦𝗦! The two-day event showcased 8 inspiring keynotes, 20 engaging talks, and attracted over 120 participants. We are truly grateful to each and every one of you for being part of this successful and memorable event. We express our deepest gratitude to our esteemed sponsors, whose support was crucial in making this conference possible. We extend our deepest appreciation to Applied Materials, Aprecia Pharmaceuticals, DFE Pharma, GASPOROX AB (Publ.), Parsum GmbH, PHOENIX OITB, Phyllon GmbH, Sentronic, Silicon Alps Cluster, SimVantage Syntegon, ZETA and of course, our Cooperation Partner Siemens We also want to express our gratitude to all the teams and individuals who worked behind the scenes to ensure the seamless execution of the event. Your hard work and dedication were truly invaluable. We look forward to seeing you again next year in Washington! #ECCPM #ECCPM2024 #ContinuousManufacturing

Last week, at the 16th Annual Conference of the European Paediatric Formulation Initiative (EuPFI), Simone Eder delivered an exciting talk titled “𝗣𝗿𝗶𝗻𝘁𝗲𝗱 𝗱𝗿𝘂𝗴-𝗹𝗼𝗮𝗱𝗲𝗱 𝘁𝗲𝗺𝗽𝗼𝗿𝗮𝗿𝘆 𝘁𝗮𝘁𝘁𝗼𝗼𝘀 – 𝗔 𝗻𝗼𝘃𝗲𝗹, 𝗵𝗶𝗴𝗵𝗹𝘆 𝗮𝗰𝗰𝗲𝗽𝘁𝗮𝗯𝗹𝗲 𝗽𝗿𝗲-𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗼𝗽𝘁𝗶𝗼𝗻 𝗳𝗼𝗿 𝗽𝗮𝗶𝗻-𝗳𝗿𝗲𝗲 𝘃𝗮𝗰𝗰𝗶𝗻𝗮𝘁𝗶𝗼𝗻𝘀 𝗳𝗼𝗿 𝗰𝗵𝗶𝗹𝗱𝗿𝗲𝗻.” This innovative method not only administers medication through the skin but also decorates it with fun, personalized designs. This approach has strong potential to address children's unique needs and improve treatment compliance. Notably, the fabrication process allows for full customization of both the drug dose and design, marking a significant leap forward in pediatric healthcare. #EuPFI2024 #RCPE #DrugDelivery #PediatricHealthcare

In the pharmaceutical world, lipid excipients play a crucial role, yet their application in 3D-printing, particularly filament-based 3D-printing, remains largely uncharted territory due to their challenging processability. In our latest publication, our scientists showcase the pioneering successful utilization of novel lipid excipient in fabricating advanced oral solid dosage forms via filament-based 3D-printing. Despite the demanding nature of this research, we are genuinely thrilled about the promising prospects it holds for the future of pharmaceutical manufacturing and personalized healthcare. Enjoy reading the publication here: https://lnkd.in/dm9XphDc #RCPE #Pharma #Manufacturing #3Dprinting #PersonalizedMedicine #Lipids #HME #Filaments #Innovation

Our CEO and Scientific Director, Johannes Khinast, is attending the Continuous Manufacturing Forum in Princeton, New Jersey this week, presenting RCPE’s unique technology and engaging with industry leaders on the latest advancements in continuous manufacturing. It’s been an exciting opportunity to exchange ideas and insights in real-time. #RCPE #CM #ContinuousManufacturing #CMForum #Innovation

The tableting of biologics is becoming increasingly popular; however, due to the sensitivity of proteins, the formulation and processing of tablets containing biologics have proven to be challenging. Ensuring the stability and efficacy of these sensitive biologics during the manufacturing process is critical. This paper investigates the effects of formulation, tableting, and spray-drying on the stability of catalase. Different saccharides (trehalose, dextran, and mannitol) are evaluated as potential stabilizers. The enzymatic activity, protein aggregation, and structural changes of catalase in non-spray-dried and spray-dried formulations (blends and tablets) are assessed. The study highlights the importance of optimizing both formulation and processing parameters to maintain the stability of biologics in tablets. Full publication: https://lnkd.in/dupK_4Ew #RCPE #BiologicsTableting #FormulationScience #DrugDevelopment #Biopharmaceuticals

𝗖𝗼𝗻𝗴𝗿𝗮𝘁𝘂𝗹𝗮𝘁𝗶𝗼𝗻𝘀 𝘁𝗼 𝗖𝗵𝗿𝗶𝘀𝘁𝗶𝗻𝗮 for winning the 𝗧𝗼𝗽 𝗣𝗼𝘀𝘁𝗲𝗿 𝗔𝘄𝗮𝗿𝗱 at the CRS Annual Meeting & Exposition in Bologna, Italy (July 8-12, 2024). Her exceptional work, titled "𝘌𝘴𝘵𝘢𝘣𝘭𝘪𝘴𝘩𝘮𝘦𝘯𝘵 𝘰𝘧 𝘢 𝘧𝘭𝘦𝘹𝘪𝘣𝘭𝘦 𝘵𝘰𝘱-𝘥𝘰𝘸𝘯 𝘮𝘢𝘯𝘶𝘧𝘢𝘤𝘵𝘶𝘳𝘪𝘯𝘨 𝘭𝘪𝘯𝘦 𝘧𝘰𝘳 𝘯𝘢𝘯𝘰-𝘱𝘩𝘢𝘳𝘮𝘢𝘤𝘦𝘶𝘵𝘪𝘤𝘢𝘭𝘴" received well-deserved recognition for its innovation and impact in the field. A special shoutout to the partners of the NanoFacT consortium for their invaluable contributions to this success. We are incredibly proud of this achievement! GATTEFOSSÉ InProcess-LSP KNAUER Microfluidics International Corporation Skyepharma Universität Graz #NanoFacT #CRS2024 #NanoPharmaceuticals #PharmaInnovation #NanoTechnology