SEGUL is an ultra-fast, memory-efficient application for working with phylogenomic datasets. We designed it to be easy for beginners in genomic studies (or bioinformatics in general) while providing advanced features for experienced users. It is available as a standalone, zero-dependency command line, GUI applications (called SEGUI), and libraries for Rust, Python, and other programming languages. It runs from your smartphone to High-Performance Computers (see platform support below). As far as we know, this is the only genomic software that can run native on mobile devices. 😉

We optimized SEGUL for speed and memory efficiency. It runs analyses in parallel automatically and is free from data races (thanks to Rust). There is no need to guess the number of cores needed for each run. It can handle large genomic datasets while using minimal computational resources. However, it also provides convenient features for working on smaller datasets (e.g., Sanger datasets). In our tests, it consistently offers a faster and more efficient (low memory footprint) alternative to existing applications for various genomic data wrangling and summarization (see benchmark).

Learn more about SEGUL in the documentation. We welcome feedback if you find any issues, dificulties or have ideas to improve the app and its documentation (details below).

Handika, H., and J. A. Esselstyn. 2024. SEGUL: Ultrafast, memory-efficient and mobile-friendly software for manipulating and summarizing phylogenomic datasets. Molecular Ecology Resources. https://doi.org/10.1111/1755-0998.13964.

• App Documentation: [EN]
• API Documentation: [Rust]
• GUI: [Source code]
• Python API: [Source code] [PyPI]

Learn more about device requirements and GUI app installation in the documentation.

The CLI app may work in any Rust supported platform. However, we only tested and officially support the following platforms:

• Linux
• MacOS
• Windows
• Windows Subsystem for Linux (WSL)

• Pre-compiled binaries: [Releases] [Docs]
• Conda: [Package] [Docs]
• Package manager: [Docs]
• From source: [Docs]
• Beta version: [Docs]

The API version is available for Rust and other programming languages. For Rust users, you can install it via Cargo:

cargo add segul

We provide binding for Python (called pysegul). Use SEGUL just like any other Python package:

pip install pysegul

Learn more about using SEGUL API in the documentation.

NOTES: To try beta features, follow the installation instruction for the beta version.

Supported sequence formats:

1. NEXUS
2. Relaxed PHYLIP
3. FASTA
4. FASTQ (gzipped and uncompressed)
5. Multiple Alignment Format (MAF) (In development)

All of the formats are supported in interleave and sequential versions. Except for FASTQ (DNA only), the app supports both DNA and amino acid sequences.

Supported partition formats:

1. RaXML
2. NEXUS

The NEXUS partition can be written as a charset block embedded in NEXUS formatted sequences or a separate file.

We welcome any kind of contribution, from issue reporting, ideas to improve the app and documentation, to code contribution. For ideas and issue reporting please post in the Github issues page. For code contribution, please fork the repository and send pull requests to this repository.