Transcription termination factor, RNA polymerase I

TTF1
Identifiers
Aliases	TTF1, TTF-1, TTF-I, Transcription termination factor, RNA polymerase I, transcription termination factor 1
External IDs	OMIM: 600777; MGI: 105044; HomoloGene: 135863; GeneCards: TTF1; OMA:TTF1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	132,406,851 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	28,977,668 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; trabecular bone; ; oocyte; ; secondary oocyte; ; pylorus; ; pericardium; ; cardia; ; nipple; ; superior surface of tongue; ; vena cava;
	Top expressed in
	gastrula; ; neural layer of retina; ; submandibular gland; ; spermatocyte; ; granulocyte; ; Paneth cell; ; thymus; ; ventricular zone; ; morula; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding; chromatin binding;
Cellular component	plasma membrane; nucleolus; nucleoplasm; cytosol; nucleus;
Biological process	DNA-templated transcription, termination; negative regulation of DNA replication; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II; cell differentiation; termination of RNA polymerase I transcription;
	Sources:Amigo / QuickGO
Orthologs
	7270
	22130
	ENSG00000125482
	ENSMUSG00000026803
	Q15361
	Q62187
	NM_001205296; NM_007344
	NM_009442
	NP_001192225; NP_031370
	NP_033468
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription termination factor 1 is a protein that in humans is encoded by the TTF1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125482 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026803 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Evers R, Grummt I (Aug 1995). "Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I". Proc Natl Acad Sci U S A. 92 (13): 5827–31. Bibcode:1995PNAS...92.5827E. doi:10.1073/pnas.92.13.5827. PMC 41863. PMID 7597036.
^ "Entrez Gene: TTF1 transcription termination factor, RNA polymerase I".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (1998). "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes". EMBO J. 17 (10): 2855–64. doi:10.1093/emboj/17.10.2855. PMC 1170626. PMID 9582279.
Muth V, Nadaud S, Grummt I, Voit R (2001). "Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription". EMBO J. 20 (6): 1353–62. doi:10.1093/emboj/20.6.1353. PMC 145524. PMID 11250901.
Strohner R, Nemeth A, Jansa P, et al. (2001). "NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines". EMBO J. 20 (17): 4892–900. doi:10.1093/emboj/20.17.4892. PMC 125270. PMID 11532953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Takano T, Ito Y, Matsuzuka F, et al. (2007). "Quantitative measurement of telomerase reverse transcriptase, thyroglobulin and thyroid transcription factor 1 mRNAs in anaplastic thyroid carcinoma tissues and cell lines". Oncol. Rep. 18 (3): 715–20. doi:10.3892/or.18.3.715. PMID 17671725.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125482 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026803 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7597036-5] Evers R, Grummt I (Aug 1995). "Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I". Proc Natl Acad Sci U S A. 92 (13): 5827–31. Bibcode:1995PNAS...92.5827E. doi:10.1073/pnas.92.13.5827. PMC 41863. PMID 7597036.

[entrez-6] "Entrez Gene: TTF1 transcription termination factor, RNA polymerase I".

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References

Further reading