Talk:Doxylamine

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Doxylamine.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Restavit

Please create an article for Restavit (Doxylamine is sold under the name Restavit in some countries) that redirects to this article. I had a hard time finding out what Restavit really was and I believe setting up this redirection might help others, thank you. —Preceding unsigned comment added by 69.120.105.248 (talk) 19:53, 28 July 2008 (UTC)[reply]

Dependency

How risky is doxylamine? Is there any risk for dependency? Zellthemedic (talk) 03:53, 14 July 2008 (UTC)[reply]

Canada in the Commonwealth?

of course it is

  I'm not sure about that.

Well, according to http://en.wikipedia.org/wiki/Commonwealth Canada is a Commonwealth nation.

Canada is absolutely in the Commonwealth 149.135.110.235 09:29, 5 December 2006 (UTC)[reply]

Structural diagram

The structural formula given in the diagram is false. It is missing an amine group in one of the rings.

Im not at all experienced at Wiki editting, so il ask if somebody else can find a correct structural diagram that includes all the amine groups. 220.233.195.181 12:30, 26 June 2006 (UTC)[reply]

I need information about the legal status of this substance in Australia.

It is an 'over the counter' drug in Australia. I bought some about 3 hours ago in Sydney :) Marked "PHARMACIST ONLY MEDICINE". 149.135.110.235 09:31, 5 December 2006 (UTC)[reply]

Anecdotal information

I'm an insomniac, and I've tried this medicine as a sleep aid. I weigh 56 kg (124 lb). It comes in tablets containing 25 mg. Try half a tablet. A whole tablet makes it very hard to get up the next day. Also, don't take two tablets at once. It made my skin and muscles hypersensitive, so that my blanket and mattress felt itchy, and it made my eyes and nose feel very dry (as one might expect from an antihistamine). Also, chasing half a tablet with a glass of wine is very effective as a "sleeping potion" of sorts. I hope this helps. Also, I don't find the article confusing, so I'm removing the tag. Peace be upon you. 24.95.48.112 09:54, 7 January 2007 (UTC)[reply]

Consuming alcohol with any hypnotic can be dangerous. Best to forego the chaser. 206.194.127.112 (talk) 21:55, 28 July 2008 (UTC)[reply]

UNISOM

This is the brand name used in the USA, I do not see this mentioned. Maybe that would imply commercial endorsement, but the brand names in other countries is shown. —The preceding unsigned comment was added by Jokem (talk • contribs) 21:45, 25 April 2007 (UTC).[reply]

"Anti-allergy power"

"...has anti-allergy power superior to almost every other antihistamine on the market, with the exception of diphenhydramine"
Frankly, this a very vague and unsourced information; also, the formulation isn't too fortunate. First, how can one quantify the antiallergic effect? Second, it seems more a personal impression than a factual information to me, and if it comes to personal impressions, clemastine, ketotifen, hydroxizine and cetirizine are the "non plus ultras" of antiallergics in my opinion. It would be great to back up the opinion given in article with some factual and objective data/source.--84.163.87.66 10:40, 28 April 2007 (UTC)[reply]

I agree that this statement needs a source, but of course it's possible to study efficacy of antihistamines vs. one another. A study would just have two groups (or more likely three, one being placebo), taking two different antihistamines, and see what percentage of each group's symptoms are alleviated. So it's kind of just a "personal impression" averaged out over a large group of people. Diphenhydramine is generally considered the gold standard for antihistamines.

On the other hand it may be silly to make a statement in the article as if there were a definite hierarchy. Different studies sometimes show different results, so sourcing is definitely necessary. --Galaxiaad 16:31, 16 October 2007 (UTC)[reply]

I sourced that claim, although it surprised me, too. Unimaginative Username (talk) 00:30, 28 March 2011 (UTC)[reply]

Pregnancy Category

According to the Wikipedia page on pregnancy categories (which appears to agree with the FDA):

Category A: Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).

Please cite an authoritative source before calling this category A, or adequate and well-controlled studies at least. I have reason to suspect this is actually category B. Epylar 05:34, 30 April 2007 (UTC)[reply]

I have not been able to find a single source that says that this drug is category A. Since that is misleading and potentially harmful information, I am removing that information promptly. --71.126.174.124 (talk) 19:23, 22 September 2011 (UTC)[reply]

Side Effects

The phrase "Other drugs with well known anticholinergic effects include many antipsychotic and tricyclic antidepressant drugs" should be removed. What does this have to do with Doxylamine? It is not an antipsychotic or antidepressant. And there are hundreds of drugs with anticholinergic effects, most of which are not antipsychotic or antidepressant.

Question about LD50 and recommended doses

How can the recommended dose be 50mg while the LD50 estimate is 50mg-500mg in humans?! That is a drastic estimate if you ask me, 50mg would be enough to kill someone with a low tolerance to this drug. —Preceding unsigned comment added by 24.231.241.197 (talk) 00:18, 19 January 2009 (UTC)[reply]

That's 50–500 mg/kg, which works out to 3.5 to 35 grams for an average 70 kilograms (150 lb) man. Fvasconcellos (t·c) 00:48, 19 January 2009 (UTC)[reply]

OTC Sedative

"It is also the most effective over-the-counter sedative available in the United States,[2]" As there are only two otc sedatives avaliable in the US, this is hardly suprising! (the other is diphenhydramine) 121.209.49.58 (talk) 03:33, 3 November 2009 (UTC) Jonathan[reply]

Aside from alcohol (see section on Indications citations), there are herbal supplements sold OTC that have been proven to have sedative effects, although I suspect that none of these were considered by the source that made the claim. Unimaginative Username (talk) 00:56, 28 March 2011 (UTC)[reply]

Encouraging bad behavior?

I noticed next to bioavailability it states that insufflation gives a 70% bioavailability as opposed to the responsibly dosed 20% by oral. This information may encourage consumers of Unisom® to insufflate the tablet rather than use as directed. This information should not be disseminated. Only the oral bioavailability should be stated as the FDA approved this substance for use ONLY be oral.

Unisom® is a registered trademark of Chattem, Inc. —Preceding unsigned comment added by 74.140.1.231 (talk) 08:26, 9 November 2010 (UTC)[reply]

Your an idiot. Wiki is supposed to be a free exchange of unbiased, and UNCENSORED information.Removing something becuase of underlying moral issues is not only petty, but irresponsible, as well — Preceding unsigned comment added by 24.98.250.155 (talk) 01:36, 23 August 2011 (UTC)[reply]

Indications citations

Added the cites and removed the cite-needed tags. The claims were strong and in some cases counter-intuitive; hence the multiple cite of almost every single claim in the first paragraph. Some sounded almost like advertising hype, but if you check the source cited, it appears to be reliable and without conflict of interest in promoting this product. (However, I'd still wonder about the claim of "most powerful OTC sedative in the US" if alcoholic beverages were included in the comparison. They are sedatives, and they are sold over-the-counter to those of legal age, even though the *intended* use may not be medicinal.) Unimaginative Username (talk) 00:27, 28 March 2011 (UTC)[reply]

Reference 2

I clicked on reference 2 expecting to see the study mentioned, but instead found a restatement of the sentence which had the citation. Is the source of the original study known? — Preceding unsigned comment added by John1492 (talk • contribs) 22:43, 28 November 2011 (UTC)[reply]

Availability in the United States

The article states that it is one of the most effective pain medications available over the counter in the United States. But then the reference that follows in a Canadian website... While visiting the US, I stopped in a Rite Aid. Not only is it not available, but it does not show-up in their computers, nor have they ever heard of it. I corrected the article to say it can be ordered online from Canadian pharmacies.Bill C. Riemers (talk) —Preceding undated comment added 13:05, 3 August 2012 (UTC)[reply]

I just undid my revisions as I notice later in the article it mentions the brand name is Unisom in the US. I was looking for Mersyndol. The reference is still confusing, as it has nothing to do about the avialability in the US. Maybe, it is being applied an the wrong point in the article.Bill C. Riemers (talk)

Availability in Canada

Moved from article. Fvasconcellos (t·c) 21:23, 30 March 2013 (UTC)[reply]

"In Canada doxylamine succinate is the active ingredient in the over-the-counter sleep-aid tablets branded as Unisom 2; while Unisom contains diphenhydramine hydrochloride as the active ingredient"

IS THIS TRUE? i've have never seen it and i have looked alot of places (wal-mart, shoppers drug mart, real canadian etc.). it seems like everything UNISOM in canada is diphenhydramine hydrochloride. EDIT: i should have been more clear. i have never seen doxylamine in pill form in canada. i check UNISOM and all its products packages often when i go into pharma sections. and i've checked most mass retailers in many provinces (NOT quebec or maritime province FWIW). two pharmacists told me they think it's legal/approved in pill form but they had no idea why no one sells it like that at B&M) — Preceding text originally posted on Doxylamine (diff) by 174.7.40.112 (talk⋅contribs) 20:28, March 30, 2013 (UTC)

ANSWER: unisom-2 was avaible a few years ago in Canada. The brandname was sold a the new owner kept the original unisom (so called unisom-1) on the market. after they withdraw unisom-2 I never found doxykamine succinate as sleep aid in canada. — Preceding unsigned comment added by 142.217.249.169 (talk) 02:12, 12 July 2013 (UTC)[reply]

Chirality of doxylamine

On looking at the molecular structure I can see that doxylamine has a stereogenic centre. Does anyone know which enantiomer is the pharmalologically active one? Seven of Nine (talk) 01:02, 5 March 2016 (UTC)[reply]

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Withdrawal effects over "longer periods of time"?

This article currently says, "If used for longer periods of time, withdrawal effects are unlikely to be experienced with prolonged use, but mild withdrawal symptoms are likely if taken long-term." What is the difference between "prolonged" and "long-term"? Apparently one is unlikely to have withdrawal effects while the other is likely to have withdrawal effects, but how are they distinguished? 74.71.81.121 (talk) 16:39, 19 October 2019 (UTC)[reply]

To have that discussion. one needs to look at what the effect are. The feel of the effect is comparable to dehydration or heat stroke, the brain gets horribly tired, alongside the anti histamine effect. Which means the user do not fall asleep faster, but instead gets too drowsy to wake up when the body goes from awake to trying to enter sleep. And a classic case of insomnia is that the body fails to go from entering sleep to sleep, meaning the only thing the user can take note of is that more time has elapsed than what is experienced.

So "withdrawal" in this case is the user going from not needing to care about being drowsy to pass trough entering sleep, to going back failing to enter sleep or the next sleep phase, and instead get woken by sleep apnea, blood pressure, poor diet, other physical issues or environmental temperature changes.

So as an example, if the user is able to have normal subpar sleep(not waking up when transition from deep to light sleep and back) via exercising daily, the user might reduce the exercise when on a type of Doxylamine drug, and then after long term use fail to return to the exercise routine needed to cope with the bad sleep quality. Or the doctor prescribing Doxylamine for insomnia for example caused by post COVID, meaning any form of treatment isn't tested, meaning the user falls back to insomnia when going off Doxylamine. Stalkerkun (talk) 22:36, 30 November 2024 (UTC)[reply]

Dementia

"Continuous and/or cumulative use of anticholinergic medications, including first-generation antihistamines, is associated with a higher risk of cognitive decline and dementia in older people.[30][31]"

[30] does not mention doxylamine at all. [31] lists it in a table of frequency of use in the class, but both of these studies are about anticholinergics in general. The studies that I've seen that actually differentiate between different anticholinergics suggest that some have a much more significant impact than others and some have virtually no impact on dementia. As far as I can tell, there are no studies that put doxylamine into a category of risk beyond it being in the class of anticholinergic. Which is to say, there's no evidence, that I've been able to find, that it actually has an impact on dementia. — Preceding unsigned comment added by 2600:1700:83E0:7360:7157:5308:448D:95B0 (talk) 16:06, 24 April 2023 (UTC)[reply]