Decoy receptor 1

TNFRSF10C
Identifiers
Aliases	TNFRSF10C, CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID, tumor necrosis factor receptor superfamily member 10c, TNF receptor superfamily member 10c
External IDs	OMIM: 603613; HomoloGene: 48244; GeneCards: TNFRSF10C; OMA:TNFRSF10C - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	23,117,445 bp
RNA expression pattern
	Top expressed in
	blood; ; granulocyte; ; testicle; ; periodontal fiber; ; bone marrow; ; gonad; ; monocyte; ; spleen; ; gallbladder; ; bone marrow cells;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transmembrane signaling receptor activity; tumor necrosis factor-activated receptor activity; TRAIL binding;
Cellular component	anchored component of membrane; integral component of plasma membrane; membrane; plasma membrane; cell surface;
Biological process	multicellular organism development; response to lipopolysaccharide; inflammatory response; regulation of cell population proliferation; immune response; signal transduction; apoptotic process; tumor necrosis factor-mediated signaling pathway; apoptotic signaling pathway; regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; TRAIL-activated apoptotic signaling pathway; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	8794
	n/a
	ENSG00000173535
	n/a
	O14798
	n/a
	NM_003841
	n/a
	NP_003832
	n/a
	Wikidata
View/Edit Human

Decoy receptor 1 (DCR1), also known as TRAIL receptor 3 (TRAILR3) and tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), is a human cell surface receptor of the TNF-receptor superfamily.^[3]^[4]^[5]

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173535 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Degli-Esposti MA, Smolak PJ, Walczak H, Waugh J, Huang CP, DuBose RF, Goodwin RG, Smith CA (Nov 1997). "Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family". J Exp Med. 186 (7): 1165–70. doi:10.1084/jem.186.7.1165. PMC 2199077. PMID 9314565.
^ MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, Alnemri ES (Nov 1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J Biol Chem. 272 (41): 25417–20. doi:10.1074/jbc.272.41.25417. PMID 9325248.
^ ^a ^b "Entrez Gene: TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain".

Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors". Cell Res. 14 (5): 359–72. doi:10.1038/sj.cr.7290236. PMID 15538968.
Pan G, Ni J, Wei YF, et al. (1997). "An antagonist decoy receptor and a death domain-containing receptor for TRAIL". Science. 277 (5327): 815–8. doi:10.1126/science.277.5327.815. PMID 9242610.
Sheridan JP, Marsters SA, Pitti RM, et al. (1997). "Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors". Science. 277 (5327): 818–21. doi:10.1126/science.277.5327.818. PMID 9242611.
Schneider P, Bodmer JL, Thome M, et al. (1997). "Characterization of two receptors for TRAIL" (PDF). FEBS Lett. 416 (3): 329–34. doi:10.1016/S0014-5793(97)01231-3. PMID 9373179. S2CID 83145771.
Mongkolsapaya J, Cowper AE, Xu XN, et al. (1998). "Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL". J. Immunol. 160 (1): 3–6. doi:10.4049/jimmunol.160.1.3. PMID 9551946.
Rieger J, Naumann U, Glaser T, et al. (1998). "APO2 ligand: a novel lethal weapon against malignant glioma?". FEBS Lett. 427 (1): 124–8. doi:10.1016/S0014-5793(98)00409-8. PMID 9613612. S2CID 5920531.
Sheikh MS, Huang Y, Fernandez-Salas EA, et al. (1999). "The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract". Oncogene. 18 (28): 4153–9. doi:10.1038/sj.onc.1202763. PMID 10435597. S2CID 22315889.
Leverkus M, Walczak H, McLellan A, et al. (2000). "Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand-mediated apoptosis". Blood. 96 (7): 2628–31. doi:10.1182/blood.V96.7.2628. PMID 11001921. S2CID 42437707.
Zhang XD, Nguyen T, Thomas WD, et al. (2000). "Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types". FEBS Lett. 482 (3): 193–9. doi:10.1016/S0014-5793(00)02042-1. PMID 11024459. S2CID 12827383.
Dörr J, Bechmann I, Waiczies S, et al. (2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain". J. Neurosci. 22 (4): RC209. doi:10.1523/JNEUROSCI.22-04-j0001.2002. PMC 6757573. PMID 11844843.
Liao Q, Friess H, Kleeff J, Büchler MW (2002). "Differential expression of TRAIL-R3 and TRAIL-R4 in human pancreatic cancer". Anticancer Res. 21 (5): 3153–9. PMID 11848467.
Bretz JD, Mezosi E, Giordano TJ, et al. (2002). "Inflammatory cytokine regulation of TRAIL-mediated apoptosis in thyroid epithelial cells". Cell Death Differ. 9 (3): 274–86. doi:10.1038/sj.cdd.4400965. PMID 11886310.
Hueber A, Aduckathil S, Kociok N, et al. (2002). "Apoptosis-mediating receptor-ligand systems in human retinal pigment epithelial cells". Graefes Arch. Clin. Exp. Ophthalmol. 240 (7): 551–6. doi:10.1007/s00417-002-0487-6. PMID 12136286. S2CID 10307168.
Matysiak M, Jurewicz A, Jaskolski D, Selmaj K (2002). "TRAIL induces death of human oligodendrocytes isolated from adult brain". Brain. 125 (Pt 11): 2469–80. doi:10.1093/brain/awf254. PMID 12390973.
Ruiz de Almodóvar C, López-Rivas A, Redondo JM, Rodríguez A (2002). "Transcription initiation sites and promoter structure of the human TRAIL-R3 gene". FEBS Lett. 531 (2): 304–8. doi:10.1016/S0014-5793(02)03544-5. PMID 12417331. S2CID 37720054.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ou D, Metzger DL, Wang X, et al. (2003). "TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction". Diabetologia. 45 (12): 1678–88. doi:10.1007/s00125-002-0926-2. PMID 12488957.
Hasel C, Dürr S, Rau B, et al. (2003). "In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas". Lab. Invest. 83 (6): 825–36. doi:10.1097/01.lab.0000073126.56932.46. PMID 12808117.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173535 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9314565-3] Degli-Esposti MA, Smolak PJ, Walczak H, Waugh J, Huang CP, DuBose RF, Goodwin RG, Smith CA (Nov 1997). "Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family". J Exp Med. 186 (7): 1165–70. doi:10.1084/jem.186.7.1165. PMC 2199077. PMID 9314565.

[pmid9325248-4] MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, Alnemri ES (Nov 1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J Biol Chem. 272 (41): 25417–20. doi:10.1074/jbc.272.41.25417. PMID 9325248.

[entrez-5] "Entrez Gene: TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain".

[1]

[2]

[3]

[4]

[5]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Function

References

Further reading