Large neutral amino acids transporter small subunit 2

SLC7A8
Identifiers
Aliases	SLC7A8, LAT2, LPI-PC1, solute carrier family 7 member 8
External IDs	OMIM: 604235; MGI: 1355323; HomoloGene: 8166; GeneCards: SLC7A8; OMA:SLC7A8 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	23,183,674 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,019,403 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; left uterine tube; ; beta cell; ; gastric mucosa; ; right ovary; ; human kidney; ; left ovary; ; oocyte; ; retinal pigment epithelium; ; decidua;
	Top expressed in
	yolk sac; ; epithelium of lens; ; right kidney; ; lip; ; islet of Langerhans; ; gastrula; ; decidua; ; superior frontal gyrus; ; muscle of thigh; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptide antigen binding; L-amino acid transmembrane transporter activity; neutral amino acid transmembrane transporter activity; toxin transmembrane transporter activity; protein binding; antiporter activity; organic cation transmembrane transporter activity; amino acid transmembrane transporter activity; transmembrane transporter activity;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; basolateral plasma membrane;
Biological process	amino acid transmembrane transport; cellular amino acid metabolic process; metal ion homeostasis; L-amino acid transport; L-alpha-amino acid transmembrane transport; amino acid transport; response to toxic substance; neutral amino acid transport; leukocyte migration; toxin transport; organic cation transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	23428
	50934
	ENSG00000092068
	ENSMUSG00000022180
	Q9UHI5
	Q9QXW9
	NM_001267036; NM_001267037; NM_012244; NM_182728
	NM_016972
	NP_001253965; NP_001253966; NP_036376; NP_877392
	NP_058668
	Wikidata
View/Edit Human	View/Edit Mouse

Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000092068 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022180 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Borsani G, Bassi MT, Sperandeo MP, De Grandi A, Buoninconti A, Riboni M, Manzoni M, Incerti B, Pepe A, Andria G, Ballabio A, Sebastio G (Mar 1999). "SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance". Nat Genet. 21 (3): 297–301. doi:10.1038/6815. PMID 10080183. S2CID 38960307.
^ Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M (Aug 1999). "Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids". J Biol Chem. 274 (28): 19738–44. doi:10.1074/jbc.274.28.19738. hdl:2445/177123. PMID 10391915.
^ "Entrez Gene: SLC7A8 solute carrier family 7 (cationic amino acid transporter, y system), member 8".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Rossier G, Meier C, Bauch C, et al. (2000). "LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine". J. Biol. Chem. 274 (49): 34948–54. doi:10.1074/jbc.274.49.34948. PMID 10574970.
Bassi MT, Sperandeo MP, Incerti B, et al. (2000). "SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family". Genomics. 62 (2): 297–303. doi:10.1006/geno.1999.5978. PMID 10610726.
Bröer A, Friedrich B, Wagner CA, et al. (2001). "Association of 4F2hc with light chains LAT1, LAT2 or y LAT2 requires different domains". Biochem. J. 355 (Pt 3): 725–31. doi:10.1042/bj3550725. PMC 1221788. PMID 11311135.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu X, Charrier L, Gewirtz A, et al. (2003). "CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia". J. Biol. Chem. 278 (26): 23672–7. doi:10.1074/jbc.M302777200. PMID 12716892.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Li S, Whorton AR (2005). "Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols". J. Biol. Chem. 280 (20): 20102–10. doi:10.1074/jbc.M413164200. PMID 15769744.
Kühne A, Kaiser R, Schirmer M, et al. (2007). "Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan". Pharmacogenet. Genomics. 17 (7): 505–17. doi:10.1097/FPC.0b013e3280ea77cd. PMID 17558306. S2CID 25402443.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000092068 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022180 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10080183-5] Borsani G, Bassi MT, Sperandeo MP, De Grandi A, Buoninconti A, Riboni M, Manzoni M, Incerti B, Pepe A, Andria G, Ballabio A, Sebastio G (Mar 1999). "SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance". Nat Genet. 21 (3): 297–301. doi:10.1038/6815. PMID 10080183. S2CID 38960307.

[pmid10391915-6] Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M (Aug 1999). "Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids". J Biol Chem. 274 (28): 19738–44. doi:10.1074/jbc.274.28.19738. hdl:2445/177123. PMID 10391915.

[entrez-7] "Entrez Gene: SLC7A8 solute carrier family 7 (cationic amino acid transporter, y system), member 8".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Large neutral amino acids transporter small subunit 2

See also

References

Further reading