SGIP1

SGIP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5AWR, 5AWT, 5AWU, 5AWS
Identifiers
Aliases	SGIP1, SH3 domain GRB2 like endophilin interacting protein 1, SH3GL interacting endocytic adaptor 1
External IDs	OMIM: 611540; MGI: 1920344; HomoloGene: 13001; GeneCards: SGIP1; OMA:SGIP1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	66,751,139 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	102,973,628 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; tibial arteries; ; Descending thoracic aorta; ; ascending aorta; ; prefrontal cortex; ; middle temporal gyrus; ; Brodmann area 46; ; Brodmann area 23; ; endothelial cell; ; C1 segment;
	Top expressed in
	Rostral migratory stream; ; neural layer of retina; ; superior frontal gyrus; ; substantia nigra; ; dentate gyrus of hippocampal formation granule cell; ; piriform cortex; ; medial dorsal nucleus; ; primary visual cortex; ; cerebellar cortex; ; medial geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; SH3 domain binding; tubulin binding; protein binding; phospholipid binding; cytoskeletal protein binding;
Cellular component	cytoplasm; plasma membrane; clathrin-coated pit; AP-2 adaptor complex; membrane; clathrin-coated vesicle; cytosol; cytoskeleton;
Biological process	positive regulation of receptor-mediated endocytosis; endocytosis; plasma membrane tubulation; membrane organization; response to dietary excess; positive regulation of feeding behavior; clathrin-dependent endocytosis; energy homeostasis; clathrin coat assembly;
	Sources:Amigo / QuickGO
Orthologs
	84251
	73094
	ENSG00000118473
	ENSMUSG00000028524
	Q9BQI5
	Q8VD37
NM_001308203; NM_032291; NM_001350217; NM_001350218; NM_001376534;
	NM_001376535; NM_001376536; NM_001376537; NM_001376538; NM_001376539; NM_001376540; NM_001376541; NM_001376542; NM_001376543; NM_001376544; NM_001376545; NM_001376546; NM_001376547; NM_001376548; NM_001376549; NM_001376550; NM_001376551; NM_001376552; NM_001376554; NM_001376555; NM_001376556; NM_001376557
	NM_001285852; NM_001285859; NM_001285860; NM_001285862; NM_144906
NP_001295132; NP_115667; NP_001337146; NP_001337147; NP_001363463;
	NP_001363464; NP_001363465; NP_001363466; NP_001363467; NP_001363468; NP_001363469; NP_001363470; NP_001363471; NP_001363472; NP_001363473; NP_001363474; NP_001363475; NP_001363476; NP_001363477; NP_001363478; NP_001363479; NP_001363480; NP_001363481; NP_001363483; NP_001363484; NP_001363485; NP_001363486
	NP_001272781; NP_001272788; NP_001272789; NP_001272791; NP_659155
	Wikidata
View/Edit Human	View/Edit Mouse

SH3-containing GRB2-like protein 3-interacting protein 1 is a protein that in humans is encoded by the SGIP1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118473 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028524 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ "Entrez Gene: SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1".

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Trevaskis J, Walder K, Foletta V, et al. (2005). "Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance". Endocrinology. 146 (9): 3757–64. doi:10.1210/en.2005-0282. hdl:10536/DRO/DU:30009269. PMID 15919751.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Uezu A, Horiuchi A, Kanda K, et al. (2007). "SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15". J. Biol. Chem. 282 (36): 26481–9. doi:10.1074/jbc.M703815200. PMID 17626015.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118473 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028524 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-6] "Entrez Gene: SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1".

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[6]

References

Further reading