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Protein-coding gene in the species Homo sapiens
Sin3A-associated protein, 30kDa , also known as SAP30 , is a protein which in humans is encoded by the SAP30 gene .[ 5]
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3A , SAP18 , HDAC1 , HDAC2 , RbAp46 , RbAp48 , and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3.[ 5]
Mammals have one paralog of SAP30, named SAP30-like (SAP30L ), which shares 70% sequence identity with SAP30.[ 6] [ 7]
Proteins of the SAP30 family (SAP30 proteins) have a functional nucleolar localization signal and they are able to target Sin3A to the nucleolus.[ 7] [ 8] zinc finger proteins and thus exemplifies the molecular mechanism how these lipids can contribute for gene regulation.[ 8] [ 9]
SAP30 has been shown to interact with:
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Ayer DE, Lawrence QA, Eisenman RN (March 1995). "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3" . Cell . 80 (5): 767–76. doi :10.1016/0092-8674(95)90355-0 PMID 7889570 . S2CID 8749951 . Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex" . Cell . 89 (3): 357–64. doi :10.1016/S0092-8674(00)80216-0 PMID 9150135 . Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D (June 1998). "SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex" . Molecular Cell . 1 (7): 1021–31. doi :10.1016/S1097-2765(00)80102-1 PMID 9651585 . Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN (July 1998). "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors" . Molecular Cell . 2 (1): 33–42. doi :10.1016/S1097-2765(00)80111-2 PMID 9702189 . Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D (October 1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities" . Cell . 95 (2): 279–89. doi :10.1016/S0092-8674(00)81758-4 PMID 9790534 . S2CID 18786866 . Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (October 1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature . 395 (6705): 917–21. Bibcode :1998Natur.395..917T . doi :10.1038/27699 . PMID 9804427 . S2CID 4355885 . Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (January 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex" . 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"Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells" . Journal of Virology . 74 (20): 9637–45. doi :10.1128/JVI.74.20.9637-9645.2000 . PMC 112396 PMID 11000236 . Underhill C, Qutob MS, Yee SP, Torchia J (December 2000). "A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1" . The Journal of Biological Chemistry . 275 (51): 40463–70. doi :10.1074/jbc.M007864200 PMID 11013263 . Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (March 2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1" . The Journal of Biological Chemistry . 276 (9): 6817–24. doi :10.1074/jbc.M007372200 PMID 11102443 . Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, Hauser CA, Gu W, Gudkov AV, Qin J (March 2001). "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex" . The Journal of Biological Chemistry . 276 (12): 8734–9. doi :10.1074/jbc.M007664200 PMID 11118440 . Yochum GS, Ayer DE (July 2001). "Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex" . Molecular and Cellular Biology . 21 (13): 4110–8. doi :10.1128/MCB.21.13.4110-4118.2001 . PMC 87072 PMID 11390640 . Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (February 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)" . Molecular and Cellular Biology . 22 (3): 835–48. doi :10.1128/MCB.22.3.835-848.2002 . PMC 133546 PMID 11784859 . Saito M, Ishikawa F (September 2002). "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2" . 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