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PDCD4

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PDCD4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDCD4, H731, programmed cell death 4 (neoplastic transformation inhibitor), programmed cell death 4
External IDsOMIM: 608610; MGI: 107490; HomoloGene: 7879; GeneCards: PDCD4; OMA:PDCD4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145341
NM_001199492
NM_014456

NM_001168491
NM_001168492
NM_011050

RefSeq (protein)

NP_001186421
NP_055271
NP_663314

NP_001161963
NP_001161964
NP_035180

Location (UCSC)Chr 10: 110.87 – 110.9 MbChr 19: 53.88 – 53.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene.[5][6] It is one of the targets of an oncomiR, MIRN21.[7]

Function

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This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.[6]

Interactions

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PDCD4 has been shown to interact with RPS13,[8] ribosomal protein L5,[8] p62, LC3 and Ubiquitin [9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150593Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024975Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Azzoni L, Zatsepina O, Abebe B, Bennett IM, Kanakaraj P, Perussia B (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells". Journal of Immunology. 161 (7): 3493–500. doi:10.4049/jimmunol.161.7.3493. PMID 9759869. S2CID 21776266.
  6. ^ a b EntrezGene 27250
  7. ^ Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH (2008). "Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells". The Journal of Biological Chemistry. 283 (2): 1026–33. doi:10.1074/jbc.M707224200. PMID 17991735.
  8. ^ a b Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.
9.  Manirujjaman M, Ozaki I, Murata Y, Guo J, Xia J, Nishioka K, Perveen R, Takahashi H,  Anzai K, Matsuhashi S (2020). "Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy". Cells. 9(1): 218. doi.org/10.3390/cells9010218.

Further reading

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