Nitrite reductase (NAD(P)H)
| nitrite reductase [NAD(P)H] | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.7.1.4 | ||||||||
| CAS no. | 9029-29-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a nitrite reductase [NAD(P)H] (EC 1.7.1.4) is an enzyme that catalyzes the chemical reaction
- ammonium hydroxide 3 NAD(P) H2O nitrite 3 NAD(P)H 3 H
The 4 substrates of this enzyme are ammonium hydroxide, NAD , NADP , and H2O, whereas its 4 products are nitrite, NADH, NADPH, and H .
This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD or NADP as acceptor. The systematic name of this enzyme class is ammonium-hydroxide:NAD(P) oxidoreductase. Other names in common use include nitrite reductase (reduced nicotinamide adenine dinucleotide, (phosphate)), NADH-nitrite oxidoreductase, NADPH-nitrite reductase, assimilatory nitrite reductase, nitrite reductase [NAD(P)H2], and NAD(P)H2:nitrite oxidoreductase. This enzyme participates in nitrogen metabolism. It has 3 cofactors: FAD, Iron, and Siroheme.
Structural studies
[edit]As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JO6.
References
[edit]- Cammack R, Jackson RH, Cornish-Bowden A, Cole JA (1982). "Electron-spin-resonance studies of the NADH-dependent nitrite reductase from Escherichia coli K12". Biochem. J. 207 (2): 333–9. doi:10.1042/bj2070333. PMC 1153865. PMID 6297458.
- Lazzarini RA; Atkinson DE (1961). "A triphosphopyridine nucleotide-specific nitrite reductase from Escherichia coli". J. Biol. Chem. 236 (12): 3330–3335. doi:10.1016/S0021-9258(18)94019-6. PMID 14463130.
- Nicholas DJ, Medina A, Jones OT (1960). "A nitrite reductase from Neurospora crassa". Biochim. Biophys. Acta. 37 (3): 468–76. doi:10.1016/0006-3002(60)90503-5. PMID 14426899.
- Taniguchi H, Mitsui H, Nakamura K, Egami F. "Ann. Acad. Sci. Fenn. Ser. A II 60 (1955) 200".
{{cite journal}}: Cite journal requires|journal=(help) - Colandene JD, Garrett RH (1996). "Functional dissection and site-directed mutagenesis of the structural gene for NAD(P)H-nitrite reductase in Neurospora crassa". J. Biol. Chem. 271 (39): 24096–104. doi:10.1074/jbc.271.39.24096. PMID 8798648.
