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Protein-coding gene in humans
β-Mannosidase (EC 3.2.1.25 }, mannanase , mannase , β-D -mannosidase , β-mannoside mannohydrolase , exo-β-D -mannanase , lysosomal β A mannosidase ) is an enzyme with systematic name β-D -mannoside mannohydrolase , which is in humans encoded by the MANBA gene .[ 5] [ 6] [ 7] [ 8] [ 9] [ 10] catalyses the following chemical reaction
Hydrolysis of terminal, non-reducing β-D -mannose residues in β-D -mannosides This gene encodes a member of the glycosyl hydrolase 2 family . The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N -linked glycoproteinoligosaccharide catabolism. Mutations in this gene are associated with β-mannosidosis , a lysosomal storage disease that has a wide spectrum of neurological involvement.[ 5]
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Anabolism Catabolism Transport M6P tagging
Activity Regulation Classification Kinetics Types
