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Protein-coding gene in humans
Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene .[ 5] [ 6] [ 7]
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000135643 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054934 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Brenner R, Jegla TJ, Wickenden A, Liu Y, Aldrich RW (Apr 2000). "Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4" . J Biol Chem . 275 (9): 6453–61. doi :10.1074/jbc.275.9.6453 PMID 10692449 . ^ Behrens R, Nolting A, Reimann F, Schwarz M, Waldschutz R, Pongs O (Jul 2000). "hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family". FEBS Lett . 474 (1): 99–106. Bibcode :2000FEBSL.474...99B . doi :10.1016/S0014-5793(00)01584-2 . PMID 10828459 . S2CID 32791798 . ^ a b "Entrez Gene: KCNMB4 potassium large conductance calcium-activated channel, subfamily M, beta member 4" .
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .
