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Judy Hirst

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Judy Hirst
FRS FMedSci
Education
Alma materUniversity of Oxford
AwardsFellow of the Academy of Medical Sciences (2019)
Scientific career
InstitutionsUniversity of Cambridge
Scripps Research Institute
ThesisElectron transport in redox enzymes (1997)
Doctoral advisorFraser Armstrong[1]
Websitewww.mrc-mbu.cam.ac.uk/research-groups/hirst-group

Judy Hirst is a British scientist specialising in mitochondrial biology. She is Director[2] of the MRC Mitochondrial Biology Unit at the University of Cambridge.

Early life and education

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Hirst grew up in Lepton, a village near Huddersfield, West Yorkshire, and attended King James's School and Greenhead College, Huddersfield.[3] She studied for an M.A. in chemistry at St John's College, Oxford,[2] and then was awarded a Doctor of Philosophy degree at Lincoln College, Oxford, in 1997, for research supervised by Fraser Armstrong on electron transport in redox enzymes.[1]

Career and research

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Following her D.Phil., Hirst held a fellowship at the Scripps Research Institute in California, before moving to Cambridge.[4]

As of 2023 Hirst is a professorial fellow and Director of Studies in Natural Sciences Chemistry at Corpus Christi College, Cambridge,[4] and since 2020 has been director of the MRC Mitochondrial Biology Unit having previously been its assistant director (2011-2014) and deputy director (2014-2020). Her main research interest is mitochondrial complex I.[2]

Hirst has been published in 2018 on Open questions: respiratory chain supercomplexes – why are they there and what do they do?[5] and working with Justin Fedor, published research on mitochondrial supercomplexes in Cell Metabolism.[6] Recent research in her team includes a study, published in May 2020 by the American Chemical Society Synthetic Biology on 'Adenosine triphosphate (ATP), the cellular energy currency, is essential for life. The ability to provide a constant supply of ATP is therefore crucial for the construction of artificial cells in synthetic biology' which has developed a 'minimal system for cellular respiration and energy regeneration'.[7]

Awards and honours

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Early in her career, Hirst was awarded EMBO Young Investigator Award (2001) and Young Investigator Award from the Royal Society of Chemistry Inorganic Biochemistry Discussion Group (2006).[8]

Hirst was elected a Fellow of the Royal Society (FRS) in 2018.[9] She was awarded an Interdisciplinary Prize of the Royal Society of Chemistry in the same year.[10] In 2019, Hirst was elected Fellow of the Academy of Medical Sciences[11] with the citation:

Judy Hirst, Professor of Biological Chemistry at the MRC Mitochondrial Biology Unit, Cambridge, has had a definitive hand in every advance towards defining the highly complex mechanism of complex I catalysis, and has developed new physical and biochemical methods to address the elusive coupling mechanism between the redox reaction and proton translocation. She established the mechanism of complex I inhibition by the anti-diabetic drug metformin, and has used kinetic and thermodynamic strategies to define how superoxide production by complex I, responds to the intramitochondrial NADH/NAD ratio to directly link two pathological effects of complex I dysfunction. This seminal work has brought understanding that is fundamental to critical issues of health and disease on a global stage.[12]

Hirst was awarded Keilin Memorial Lecture and Medal in 2020 for research which:

has made pivotal contributions to understanding energy conversion in complex redox enzymes: how they capture the energy released by a redox reaction to power proton translocation across a membrane, or catalyse the interconversion of chemical bond energy and electrical potential. She is known particularly for her work on mammalian respiratory complex I (NADH: ubiquinone oxidoreductase), an energy-transducing, mitochondrial redox enzyme of fundamental and medical importance, and for solving its structure by electron cryomicroscopy.[13][14]

References

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  1. ^ a b Hirst, Judy (1997). Electron transport in redox enzymes. bodleian.ox.ac.uk (DPhil thesis). University of Oxford. OCLC 557413704. EThOS uk.bl.ethos.364043.
  2. ^ a b c "Judy Hirst FRS | MRC Mitochondrial Biology Unit". www.mrc-mbu.cam.ac.uk. Archived from the original on 8 May 2019. Retrieved 16 August 2020.
  3. ^ "Dr Judy Hirst MA, DPhil, FRS". www.greenhead.ac.uk. Retrieved 16 August 2020.
  4. ^ a b "Dr Judy Hirst MA DPhil (Oxford) FRS FMedSci". Corpus Christi College. Retrieved 3 July 2023.
  5. ^ Hirst, Judy (2018). "Open questions: respiratory chain supercomplexes-why are they there and what do they do?". BMC Biol. 16 (1): 111. doi:10.1186/s12915-018-0577-5. ISSN 1741-7007. PMC 6211484. PMID 30382836.
  6. ^ Fedor, Justin; Hirst, Judy (2018). "Mitochondrial Supercomplexes Do Not Enhance Catalysis by Quinone Channeling". Cell Metab. 28 (3): 525–531.e4. doi:10.1016/j.cmet.2018.05.024. ISSN 1932-7420. PMC 6125145. PMID 29937372.
  7. ^ Biner, Olivier; Fedor, Justin G.; Yin, Zhan; Hirst, Judy (19 June 2020). "Bottom-Up Construction of a Minimal System for Cellular Respiration and Energy Regeneration". ACS Synthetic Biology. 9 (6): 1450–1459. doi:10.1021/acssynbio.0c00110. PMC 7611821. PMID 32383867.
  8. ^ "RSC Interdisciplinary Prize 2018 Winner". www.rsc.org. Retrieved 16 August 2020.
  9. ^ "Judy Hirst". royalsociety.org. Retrieved 10 May 2018.
  10. ^ "2018 Interdisciplinary Prize Winner: Dr Judy Hirst". Royal Society of Chemistry. Retrieved 10 May 2018.
  11. ^ "New Fellows: 50 top biomedical and health scientists join the Academy | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 16 August 2020.
  12. ^ "Professor Judy Hirst | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 16 August 2020.
  13. ^ "The Keilin Memorial Lecture". www.biochemistry.org. Retrieved 3 July 2023.
  14. ^ "Professor Judy Hirst FRS receives Keilin Memorial Lecture Award". Corpus Christi College University of Cambridge. 1 April 2019. Retrieved 16 August 2020.
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