HMGXB4

HMGXB4
Identifiers
Aliases	HMGXB4, Hmgxb4, 4733401K04Rik, AI316803, E430025G12, Hmgb2l1, HMG2L1, HMGBCG, THC211630, HMG-box containing 4, P53N
External IDs	OMIM: 604702; MGI: 1918073; HomoloGene: 4007; GeneCards: HMGXB4; OMA:HMGXB4 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	35,295,807 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	75,758,606 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; buccal mucosa cell; ; sperm; ; sural nerve; ; testicle; ; ventricular zone; ; gonad; ; placenta; ; tibia;
	Top expressed in
	zygote; ; secondary oocyte; ; genital tubercle; ; tail of embryo; ; primary oocyte; ; Rostral migratory stream; ; ventricular zone; ; primitive streak; ; medullary collecting duct; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding;
Cellular component	NURF complex; nucleus;
Biological process	negative regulation of Wnt signaling pathway; Wnt signaling pathway; endosome to lysosome transport;
	Sources:Amigo / QuickGO
Orthologs
	10042
	70823
	ENSG00000100281
	ENSMUSG00000034518
	Q9UGU5
	n/a
	NM_001003681; NM_005487; NM_014250; NM_001362972
	NM_178017; NM_001316753; NM_001316754
	NP_001003681; NP_001349901
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

HMG-box containing 4 is a protein that in humans is encoded by the HMGXB4 gene. ^[5]

Function

High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100281 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034518 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: HMG-box containing 4". Retrieved 2017-11-17.

Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR, Feinberg AP, McMahon FJ (2008). "Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1". Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (1): 59–67. doi:10.1002/ajmg.b.30574. PMID 17671966.
Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR, Feinberg AP, McMahon FJ (2008). "Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1". Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (1): 59–67. doi:10.1002/ajmg.b.30574. PMID 17671966.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Zhou J, Hu G, Wang X (2010). "Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1". J. Biol. Chem. 285 (30): 23177–85. doi:10.1074/jbc.M110.109868. PMC 2906311. PMID 20511232.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutat. Res. 694 (1–2): 13–9. doi:10.1016/j.mrfmmm.2010.08.006. PMID 20800603.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100281 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034518 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: HMG-box containing 4". Retrieved 2017-11-17.

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[5]

Function

References

Further reading