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FRAT2

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FRAT2
Identifiers
AliasesFRAT2, WNT signaling pathway regulator, FRAT-2, FRAT regulator of WNT signaling pathway 2
External IDsOMIM: 605006; MGI: 2673967; HomoloGene: 8095; GeneCards: FRAT2; OMA:FRAT2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012083

NM_177603

RefSeq (protein)

NP_036215

NP_808271

Location (UCSC)Chr 10: 97.33 – 97.33 MbChr 19: 41.83 – 41.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene.[5][6][7]

The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181274Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047604Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D (Jul 1998). "GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis". Cell. 93 (6): 1031–41. doi:10.1016/S0092-8674(00)81208-8. PMID 9635432. S2CID 17951152.
  6. ^ Saitoh T, Moriwaki J, Koike J, Takagi A, Miwa T, Shiokawa K, Katoh M (Mar 2001). "Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway". Biochem Biophys Res Commun. 281 (3): 815–20. doi:10.1006/bbrc.2001.4421. PMID 11237732.
  7. ^ a b "Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2".

Further reading

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