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David A. Fidock

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David A. Fidock
Education
Scientific career
FieldsMicrobiology, immunology
Institutions
Thesis Molecular and Immuno-Epidemiological Studies of the Plasmodium falciparum STARP and LSA-1 Antigens Expressed During the Pre-Erythrocytic Stages in Humans  (1994)
Doctoral advisorPierre Druilhe
Websitewww.fidock.org

David A. Fidock (born 8 December 1965), is the CS Hamish Young Professor of Microbiology and Immunology and Professor of Medical Sciences at Columbia University Irving Medical Center in Manhattan.[1][2][3]

Education

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Fidock attended the University of Adelaide and earned a bachelor of mathematical sciences and an honors degree in genetics in 1985. He earned a PhD in microbiology from the Institut Pasteur in Paris in 1994. His dissertation advisor was Pierre Druilhe, and his thesis was titled "Molecular and Immuno-Epidemiological Studies of the Plasmodium falciparum STARP and LSA-1 Antigens Expressed During the Pre-Erythrocytic Stages in Humans".[4][5][6] He underwent postdoctoral training with Anthony James at University of California, Irvine, and with Thomas Wellems at the National Institutes of Health.[4]

Career

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After his post-doctoral training, Fidock joined the Albert Einstein College of Medicine in New York as an Assistant Professor in the Department of Microbiology and Immunology. In 2007, Fidock became an Associate Professor at Columbia University in the Departments of Microbiology and Immunology and of Medicine (Division of Infectious Diseases).[2] Since 2008, Fidock has been a tenured Professor of Microbiology and Immunology and of Medical Sciences at Columbia.[2] In 2017 he received the C.S. Hamish Young endowed Professorship. From 2008-2023 he served as the Program Director of the NIH T32-funded Graduate Program in Microbiology, Immunology, and Infection. In 2023, he was elected as the incoming President of the American Society of Tropical Medicine and Hygiene.[7]

Research

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Fidock's research focuses on the genetic and molecular mechanisms behind antimalarial drug resistance in the human parasite Plasmodium falciparum, as well as target-based drug discovery and development, and parasite metabolism and biology.[8][9][10][non-primary source needed] He led the development of methods for genetically modifying malaria parasites and for elucidating the genetic basis of P. falciparum resistance to various first-line medicines (including artemisinin, chloroquine and piperaquine).[11][12][13][non-primary source needed]

He has published more than 280 papers on malaria, with a current h-index of 97. His work has been cited over 34,000 times. His work has been funded by the NIH, the Bill & Melinda Gates Foundation, the Department of Defense, the Burroughs Wellcome Fund and the Medicines for Malaria Venture.[14][2][8][7][15]

Honors

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Publications

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  • Determinants of piperaquine-resistant malaria in South America. Lancet Infect Dis. (Epub ahead of print.)[17]
  • The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance. Cell Chem Biol (in press).[18]
  • Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness. Elife 10: e66277.[19]
  • Inhibition of resistance-refractory P. falciparum kinase PKG delivers prophylactic, blood stage, and transmission-blocking antiplasmodial activity. Cell Chem Biol 27: 806-16.[20]
  • Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13. PLoS Pathog 16: e1008482.[21]
  • Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. PLoS Pathog 15: e1007722.[22]
  • Plasmodium falciparum resistance to piperaquine driven by PfCRT. Lancet Infect Dis 19: 1168-9.[23]
  • Structure and drug resistance of the Plasmodium falciparum transporter PfCRT. Nature 576: 315-20.[24]

References

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  1. ^ "Faculty - David A. Fidock". Department of Microbiology & Immunology -US. Retrieved 2022-01-04.
  2. ^ a b c d e "David A. Fidock, PhD". Vagelos College of Physicians and Surgeons. 2017-06-12. Retrieved 2022-01-04.
  3. ^ "David Fidock". scholar.google.com. Retrieved 2022-01-04.
  4. ^ a b "David A. Fidock, PhD". Columbia University. 12 June 2017. Retrieved 2022-01-04.
  5. ^ "David Fidock". Delgeme. Archived from the original on 2022-07-21. Retrieved 2022-01-04.
  6. ^ "Welcome Message from our President, Dr. Mahalia Desruisseaux" (PDF). ASTMH. 2021.
  7. ^ a b c d e f g h i j k l m "David Fidock". The Fidock Lab. Retrieved 2023-12-01.
  8. ^ a b c d e f g "MMV awards Project of the Year 2020 to Professor David Fidock and team for critical contribution to malaria drug resistance profiling | Medicines for Malaria Venture". www.mmv.org. 18 December 2020. Retrieved 2022-01-04.
  9. ^ Blasco, Benjamin; Leroy, Didier; Fidock, David A (2017-08-04). "Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic". Nature Medicine. 23 (8): 917–928. doi:10.1038/nm.4381. ISSN 1078-8956. PMC 5747363. PMID 28777791.
  10. ^ Miguel-Blanco, Celia; Murithi, James M.; Benavente, Ernest Diez; Angrisano, Fiona; Sala, Katarzyna A.; van Schalkwyk, Donelly A.; Vanaerschot, Manu; Schwach, Frank; Fuchter, Matthew J.; Billker, Oliver; Sutherland, Colin J. (2021-01-21). "The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957". Scientific Reports. 11 (1): 1888. doi:10.1038/s41598-021-81343-z. ISSN 2045-2322. PMC 7820608. PMID 33479319.
  11. ^ Duffey, Maëlle; Blasco, Benjamin; Burrows, Jeremy N.; Wells, Timothy N. C.; Fidock, David A.; Leroy, Didier (2021-08-01). "Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials". Trends in Parasitology. 37 (8): 709–721. doi:10.1016/j.pt.2021.04.006. ISSN 1471-4922. PMC 8282644. PMID 34001441.
  12. ^ Ekland, Eric H.; Fidock, David A. (August 2007). "Advances in understanding the genetic basis of antimalarial drug resistance". Current Opinion in Microbiology. 10 (4): 363–370. doi:10.1016/j.mib.2007.07.007. ISSN 1369-5274. PMC 2080794. PMID 17709280.
  13. ^ Miguel-Blanco, Celia; Murithi, James M.; Benavente, Ernest Diez; Angrisano, Fiona; Sala, Katarzyna A.; van Schalkwyk, Donelly A.; Vanaerschot, Manu; Schwach, Frank; Fuchter, Matthew J.; Billker, Oliver; Sutherland, Colin J. (2021-01-21). "The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957". Scientific Reports. 11 (1): 1888. doi:10.1038/s41598-021-81343-z. ISSN 2045-2322. PMC 7820608. PMID 33479319.
  14. ^ a b "MMV awards Project of the Year 2020 to Professor David Fidock and team for critical contribution to malaria drug resistance profiling - Medicines for Malaria Venture". www.mmv.org. 18 December 2020. Retrieved 2022-03-16.
  15. ^ a b c d e f g "David Fidock". Advance The Global Australian Network. Retrieved 2023-12-01.
  16. ^ a b c d e "astmh.org" (PDF).
  17. ^ Mok, Sachel; Fidock, David A. (2023-10-16). "Determinants of piperaquine-resistant malaria in South America". The Lancet. Infectious Diseases: S1473–3099(23)00564–9. doi:10.1016/S1473-3099(23)00564-9. ISSN 1474-4457. PMC 10872569. PMID 37858324.
  18. ^ Murithi, James M.; Deni, Ioanna; Pasaje, Charisse Flerida A.; Okombo, John; Bridgford, Jessica L.; Gnädig, Nina F.; Edwards, Rachel L.; Yeo, Tomas; Mok, Sachel; Burkhard, Anna Y.; Coburn-Flynn, Olivia (2021-07-06). "The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance". Cell Chemical Biologyglish. 29 (5): S2451-9456(21)00305–6. doi:10.1016/j.chembiol.2021.06.006. ISSN 2451-9456. PMC 8727639. PMID 34233174.
  19. ^ Stokes, Barbara H; Dhingra, Satish K; Rubiano, Kelly; Mok, Sachel; Straimer, Judith; Gnädig, Nina F; Deni, Ioanna; Schindler, Kyra A; Bath, Jade R; Ward, Kurt E; Striepen, Josefine (2021-07-19). Soldati-Favre, Dominique (ed.). "Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness". eLife. 10: e66277. doi:10.7554/eLife.66277. ISSN 2050-084X. PMC 8321553. PMID 34279219.
  20. ^ Vanaerschot, Manu; Murithi, James M.; Pasaje, Charisse Flerida A.; Ghidelli-Disse, Sonja; Dwomoh, Louis; Bird, Megan; Spottiswoode, Natasha; Mittal, Nimisha; Arendse, Lauren B.; Owen, Edward S.; Wicht, Kathryn J. (2020-07-16). "Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity". Cell Chemical Biologyglish. 27 (7): 806–816.e8. doi:10.1016/j.chembiol.2020.04.001. ISSN 2451-9456. PMC 7369637. PMID 32386326.
  21. ^ Gnädig, Nina F.; Stokes, Barbara H.; Edwards, Rachel L.; Kalantarov, Gavreel F.; Heimsch, Kim C.; Kuderjavy, Michal; Crane, Audrey; Lee, Marcus C. S.; Straimer, Judith; Becker, Katja; Trakht, Ilya N. (2020-04-20). "Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13". PLOS Pathogens. 16 (4): e1008482. doi:10.1371/journal.ppat.1008482. ISSN 1553-7374. PMC 7192513. PMID 32310999.
  22. ^ Stokes, Barbara H.; Yoo, Euna; Murithi, James M.; Luth, Madeline R.; Afanasyev, Pavel; Fonseca, Paula C. A. da; Winzeler, Elizabeth A.; Ng, Caroline L.; Bogyo, Matthew; Fidock, David A. (2019-06-06). "Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents". PLOS Pathogens. 15 (6): e1007722. doi:10.1371/journal.ppat.1007722. ISSN 1553-7374. PMC 6553790. PMID 31170268.
  23. ^ Dhingra, Satish K.; Small-Saunders, Jennifer L.; Ménard, Didier; Fidock, David A. (2019-11-01). "Plasmodium falciparum resistance to piperaquine driven by PfCRT". The Lancet Infectious Diseasesglish. 19 (11): 1168–1169. doi:10.1016/S1473-3099(19)30543-2. ISSN 1473-3099. PMC 6943240. PMID 31657776.
  24. ^ Kim, Jonathan; Tan, Yong Zi; Wicht, Kathryn J.; Erramilli, Satchal K.; Dhingra, Satish K.; Okombo, John; Vendome, Jeremie; Hagenah, Laura M.; Giacometti, Sabrina I.; Warren, Audrey L.; Nosol, Kamil (December 2019). "Structure and drug resistance of the Plasmodium falciparum transporter PfCRT". Nature. 576 (7786): 315–320. doi:10.1038/s41586-019-1795-x. ISSN 1476-4687. PMC 6911266. PMID 31776516.
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