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Protein-coding gene in the species Homo sapiens
Dolichyl-diphosphooligosaccharide—protein glycosyltransferase 48 kDa subunit is an enzyme that in humans is encoded by the DDOST gene .[ 5] [ 6]
This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum . The protein complex co-purifies with ribosomes . The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia .[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000244038 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028757 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Yamagata T, Tsuru T, Momoi MY, Suwa K, Nozaki Y, Mukasa T, Ohashi H, Fukushima Y, Momoi T (Jan 1998). "Genome organization of human 48-kDa oligosaccharyltransferase (DDOST)". Genomics . 45 (3): 535–40. doi :10.1006/geno.1997.4966 . PMID 9367678 . ^ a b "Entrez Gene: DDOST dolichyl-diphosphooligosaccharide-protein glycosyltransferase" .
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