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Protein-coding gene in the species Homo sapiens
Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene .[ 5] [ 6]
Human CKAP2 gene, the cDNA of which is known as LB1, is a cytoskeleton -associated protein involved in mitotic progression. Its high transcriptional activity has been observed in the testes , thymus , and diffuse B-cell lymphomas . The gene codes for a protein of 683 residues, which lacks a homology to known amino acid sequences. On evidence of immunofluorescence analysis, the CKAP2 product is a cytoplasmic protein associated with cytoskeletal fibrils.
The CKAP2 gene is in chromosome 13q 14. Rearrangements of this region result in various tumors. Thus deletions have been detected in multiple myeloma , prostate cancer , head-and-neck squamous-cell carcinoma , B-cell prolymphocytic leukemia , non-Hodgkin lymphoma , and in more than half cases of B-cell chronic lymphocytic leukemia .
^ a b c GRCh38: Ensembl release 89: ENSG00000136108 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037725 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Maouche-Chretien L, Deleu N, Badoual C, Fraissignes P, Berger R, Gaulard P, Romeo PH, Leroy-Viard K (Oct 1998). "Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B cell lymphomas". Oncogene . 17 (10): 1245–51. doi :10.1038/sj.onc.1202048 . PMID 9771967 . S2CID 24883661 . ^ "Entrez Gene: CKAP2 cytoskeleton associated protein 2" .
Alternative titles: tumor- and microtubule-associated protein; TMAP, LB1
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