CatSper4

CATSPER4
Identifiers
Aliases	CATSPER4, CatSper4, cation channel sperm associated 4
External IDs	OMIM: 609121; MGI: 3043288; HomoloGene: 18638; GeneCards: CATSPER4; OMA:CATSPER4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,202,968 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	133,954,694 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; muscle of thigh; ; gastrocnemius muscle; ; skeletal muscle tissue; ; mucosa of transverse colon; ; right uterine tube; ; lobe of thyroid gland; ; left lobe of thyroid gland; ; tibial nerve;
	Top expressed in
	spermatid; ; testicle; ; spermatocyte; ; muscle of thigh; ; neural layer of retina; ; embryo; ; muscle tissue; ; quadriceps femoris muscle; ; jejunum; ; skeletal muscle tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated calcium channel activity; calcium activated cation channel activity; calcium channel activity; voltage-gated ion channel activity; ion channel activity; NAADP-sensitive calcium-release channel activity;
Cellular component	integral component of membrane; CatSper complex; cell projection; membrane; plasma membrane; cilium; sperm principal piece; acrosomal vesicle; motile cilium;
Biological process	flagellated sperm motility; cell differentiation; membrane depolarization during action potential; sodium ion transport; regulation of ion transmembrane transport; ion transport; multicellular organism development; calcium ion transmembrane transport; transmembrane transport; spermatogenesis; sperm-egg recognition; sperm capacitation; release of sequestered calcium ion into cytosol; calcium ion transport; response to progesterone;
	Sources:Amigo / QuickGO
Orthologs
	378807
	329954
	ENSG00000188782
	ENSMUSG00000048003
	Q7RTX7
	Q8BVN3
	NM_198137
	NM_001130030; NM_177866
	NP_937770
	NP_001123502; NP_808534
	Wikidata
View/Edit Human	View/Edit Mouse

CatSper4, is a protein which in humans is encoded by the CATSPER4 gene.^[5]^[6]^[7] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²-permeant ion channel specific essential for the correct function of sperm cells.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188782 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048003 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC 184451. PMID 12932298.
^ Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895. PMID 17227845.
^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.
^ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188782 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048003 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12932298-5] Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC 184451. PMID 12932298.

[pmid17227845-6] Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895. PMID 17227845.

[pmid16382101-7] Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.

[IUPHAR-DB-8] *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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