Bromodifluoroacetyl chloride

Bromodifluoroacetyl chloride
Names
	Preferred IUPAC name Bromodi(fluoro)acetyl chloride
	Other names 2-Bromo-2,2-difluoroacetyl chloride; 2-Bromo-2,2-difluoro-ethanoyl chloride
Identifiers
CAS Number	3832-48-2 ;
3D model (JSmol)	Interactive image;
ChemSpider	454349 ;
ECHA InfoCard	100.197.413
EC Number	671-811-0;
PubChem CID	520892;
CompTox Dashboard (EPA)	DTXSID90334487 ;
	InChI InChI=1S/C2BrClF2O/c3-2(5,6)1(4)7 Key: LYJKGSALBRSKNL-UHFFFAOYSA-N ; InChI=1/C2BrClF2O/c3-2(5,6)1(4)7 Key: LYJKGSALBRSKNL-UHFFFAOYAW;
	SMILES C(=O)(C(F)(F)Br)Cl;
Properties
Chemical formula	C2BrClF2O
Molar mass	193.37 g·mol−1
Appearance	liquid
Boiling point	50 °C (122 °F; 323 K)
Hazards
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H226, H314
Precautionary statements	P210, P233, P240, P241, P242, P243, P260, P264, P280, P301 P330 P331, P303 P361 P353, P304 P340, P305 P351 P338, P310, P321, P363, P370 P378, P403 P235, P405, P501
Safety data sheet (SDS)	[1]
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Bromodifluoroacetyl chloride is a chemical compound with the formula BrCF₂COCl. It has been used as a starting material for the synthesis of (biologically active) α,α-difluoro-γ-lactams^[1] and has been used in the synthesis of trifluoromethylated C-nucleosides.^[2]

References

^ Nagashima, H.; Isono, Y.; Iwamatsu, S. (2001). "Copper-Catalyzed Cyclization of N-Allylhalodifluoroacetamides: An Efficient Synthesis of α,α-difluoro-γ-lactams". Journal of Organic Chemistry. 66 (1): 315–319. doi:10.1021/jo001187f. PMID 11429918.
^ Mamata, C.; Heina, M.; Miethchen, R. (2006). "Fluorinated acyclo-C-nucleoside analogues from glycals in two steps". Carbohydrate Research. 341 (10): 1758–1763. doi:10.1016/j.carres.2006.01.011. PMID 16442508.

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[1] Nagashima, H.; Isono, Y.; Iwamatsu, S. (2001). "Copper-Catalyzed Cyclization of N-Allylhalodifluoroacetamides: An Efficient Synthesis of α,α-difluoro-γ-lactams". Journal of Organic Chemistry. 66 (1): 315–319. doi:10.1021/jo001187f. PMID 11429918.

[2] Mamata, C.; Heina, M.; Miethchen, R. (2006). "Fluorinated acyclo-C-nucleoside analogues from glycals in two steps". Carbohydrate Research. 341 (10): 1758–1763. doi:10.1016/j.carres.2006.01.011. PMID 16442508.

[1]

[2]

See also

References