9-Phenanthrol

9-Phenanthrol
Names
	IUPAC name 9-Phenanthrol
	Systematic IUPAC name 9-Hydroxyphenanthrene
	Other names 9-Phenanthrol; 9-Phenanthrenol; Phenanthren-9-ol; 9-Hydroxyphenanthrene;
Identifiers
CAS Number	484-17-3 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:28820;
ChEMBL	ChEMBL2407182;
ChemSpider	9812;
ECHA InfoCard	100.006.912
EC Number	207-602-4;
KEGG	C11430;
PubChem CID	10229;
UNII	9FYU45OV9H ;
CompTox Dashboard (EPA)	DTXSID9047592 ;
	InChI InChI=1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H Key: DZKIUEHLEXLYKM-UHFFFAOYSA-N;
	SMILES C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O;
Properties
Chemical formula	C14H10O
Molar mass	194.233 g·mol−1
Hazards
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H315, H319, H335
Precautionary statements	P261, P264, P271, P280, P302 P352, P304 P340, P305 P351 P338, P312, P321, P332 P313, P337 P313, P362, P403 P233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

9-Phenanthrol is an aromatic alcohol derived from phenanthrene, a tricyclic compound. It is a TRPM4 channel inhibitor.^[1] It can prevent the pancreas from secreting insulin when stimulated by glucose.^[2]

References

^ Guinamard, R; Hof, T; Del Negro, C A (2014). "The TRPM4 channel inhibitor 9-phenanthrol". British Journal of Pharmacology. 171 (7): 1600–1613. doi:10.1111/bph.12582. PMC 3966741. PMID 24433510.
^ Ma, Zuheng; Björklund, Anneli; Islam, Md. Shahidul (2017). "A TRPM4 Inhibitor 9-Phenanthrol Inhibits Glucose- and Glucagon-Like Peptide 1-Induced Insulin Secretion from Rat Islets of Langerhans". Journal of Diabetes Research. 2017: 1–5. doi:10.1155/2017/5131785. PMC 5643033. PMID 29098165.

[1] Guinamard, R; Hof, T; Del Negro, C A (2014). "The TRPM4 channel inhibitor 9-phenanthrol". British Journal of Pharmacology. 171 (7): 1600–1613. doi:10.1111/bph.12582. PMC 3966741. PMID 24433510.

[2] Ma, Zuheng; Björklund, Anneli; Islam, Md. Shahidul (2017). "A TRPM4 Inhibitor 9-Phenanthrol Inhibits Glucose- and Glucagon-Like Peptide 1-Induced Insulin Secretion from Rat Islets of Langerhans". Journal of Diabetes Research. 2017: 1–5. doi:10.1155/2017/5131785. PMC 5643033. PMID 29098165.

[1]

[2]