5,10-Methenyltetrahydrofolate
Appearance
Names | |
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IUPAC name
N-[4-(3-amino-1-oxo-1,4,5,6,6a,7-hexahydro-8H-imidazo[1,5-f]pteridin-10-ium-8-yl)benzoyl]-L-glutamic acid
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Other names
5,10-CH=THF
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
MeSH | 5,10-methenyltetrahydrofolate |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C20H21N7O6 | |
Molar mass | 455.42 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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5,10-Methenyltetrahydrofolate (5,10-CH=THF) is a form of tetrahydrofolate that is an intermediate in metabolism. 5,10-CH=THF is a coenzyme that accepts and donates methenyl (CH=) groups.
It is produced from 5,10-methylenetetrahydrofolate by either a NAD dependent methylenetetrahydrofolate dehydrogenase, or a NADP dependent dehydrogenase.[1] It can also be produced as an intermediate in histidine catabolism, by formiminotransferase cyclodeaminase, from 5-formiminotetrahydrofolate.
5,10-CH=THF is a substrate for methenyltetrahydrofolate cyclohydrolase, which converts it into 10-formyltetrahydrofolate.
Interactive pathway map
[edit]Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
- ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".
References
[edit]- ^ Fowler B (February 2001). "The folate cycle and disease in humans". Kidney Int. Suppl. 78: S221–9. doi:10.1046/j.1523-1755.2001.07851.x. PMID 11169015.