A vesicular transport protein, or vesicular transporter, is a membrane protein that regulates or facilitates the movement of specific molecules across a vesicle's membrane.[1] As a result, vesicular transporters govern the concentration of molecules within a vesicle.
Types
editExamples include:
- Archain
- ARFs
- Clathrin
- Caveolin
- Dynamin and related proteins, such as the EHD protein family
- Rab proteins
- SNAREs
- Vesicular transport adaptor proteins e.g. Sorting nexins
- Synaptotagmin
- TRAPP complex
- Synaptophysin
- Auxilin
Pathways
editThere are multiple pathways, each using its own coat and GTPase.[2]
- COP 1 (Cytosolic coat protein complex ) : retrograde transport; Golgi ----> Endoplasmic reticulum
- COP 2 (Cytosolic coat protein complex ) : anterograde transport; RER -----> cis-Golgi
- Clathrin : trans-Golgi ----> Lysosomes, Plasma membrane ----> Endosomes (receptor-mediated endocytosis)
See also
editReferences
edit- ^ Vesicular Transport Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ Yasushi Sako (1 October 2010). Cell Signaling Reactions: Single-Molecular Kinetic Analysis. Springer. pp. 168–. ISBN 978-90-481-9863-4. Retrieved 15 December 2010.
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