Vesicular glutamate transporter 1

SLC17A7
Identifiers
Aliases	SLC17A7, BNPI, VGLUT1, solute carrier family 17 member 7
External IDs	OMIM: 605208; MGI: 1920211; HomoloGene: 113454; GeneCards: SLC17A7; OMA:SLC17A7 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,442,360 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,825,566 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; superior frontal gyrus; ; Brodmann area 10; ; frontal pole; ; Region I of hippocampus proper; ; middle temporal gyrus; ; Brodmann area 46; ; dorsolateral prefrontal cortex; ; orbitofrontal cortex;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; prefrontal cortex; ; piriform cortex; ; cerebellar cortex; ; hippocampus proper; ; primary motor cortex; ; subiculum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	inorganic phosphate transmembrane transporter activity; sodium:inorganic phosphate symporter activity; extracellularly glutamate-gated chloride channel activity; symporter activity; L-glutamate transmembrane transporter activity; neurotransmitter transmembrane transporter activity;
Cellular component	postsynapse; integral component of membrane; membrane; synaptic vesicle; plasma membrane; synapse; excitatory synapse; synaptic vesicle membrane; cerebellar mossy fiber; presynaptic active zone; cell junction; intracellular organelle; neuron projection; clathrin-sculpted glutamate transport vesicle membrane; cytoplasmic vesicle; integral component of synaptic vesicle membrane;
Biological process	phosphate ion transport; synaptic transmission, glutamatergic; sodium-dependent phosphate transport; sodium ion transport; chloride transmembrane transport; ion transport; glutamate secretion; synaptic vesicle lumen acidification; brain development; long-term memory; excitatory postsynaptic potential; neurotransmitter transport; neural retina development; L-glutamate import; sequestering of neurotransmitter; sodium ion transmembrane transport; transmembrane transport; chemical synaptic transmission; neurotransmitter loading into synaptic vesicle; L-glutamate transmembrane transport; regulation of synaptic vesicle endocytosis; regulation of synapse structure or activity;
	Sources:Amigo / QuickGO
Orthologs
	57030
	72961
	ENSG00000104888
	ENSMUSG00000070570
	Q9P2U7
	Q3TXX4
	NM_020309
	NM_182993
	NP_064705
	NP_892038
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.^[5]^[6]^[7]

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na /Pi cotransporter family.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104888 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070570 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na( )-dependent inorganic phosphate cotransporter". J Neurochem. 66 (6): 2227–38. doi:10.1046/j.1471-4159.1996.66062227.x. PMID 8632143. S2CID 23177236.2227-38&rft.date=1996-07&rft_id=https://api.semanticscholar.org/CorpusID:23177236#id-name=S2CID&rft_id=info:pmid/8632143&rft_id=info:doi/10.1046/j.1471-4159.1996.66062227.x&rft.aulast=Ni&rft.aufirst=B&rft.au=Du, Y&rft.au=Wu, X&rft.au=DeHoff, BS&rft.au=Rosteck, PR Jr&rft.au=Paul, SM&rfr_id=info:sid/en.wikipedia.org:Vesicular glutamate transporter 1" class="Z3988">
^ Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na( )-dependent inorganic phosphate cotransporter". J Neurochem. 74 (6): 2622–5. doi:10.1046/j.1471-4159.2000.0742622.x. PMID 10820226. S2CID 37857748.2622-5&rft.date=2000-06&rft_id=https://api.semanticscholar.org/CorpusID:37857748#id-name=S2CID&rft_id=info:pmid/10820226&rft_id=info:doi/10.1046/j.1471-4159.2000.0742622.x&rft.aulast=Aihara&rft.aufirst=Y&rft.au=Mashima, H&rft.au=Onda, H&rft.au=Hisano, S&rft.au=Kasuya, H&rft.au=Hori, T&rft.au=Yamada, S&rft.au=Tomura, H&rft.au=Yamada, Y&rft.au=Inoue, I&rft.au=Kojima, I&rft.au=Takeda, J&rft_id=https://doi.org/10.1046%2Fj.1471-4159.2000.0742622.x&rfr_id=info:sid/en.wikipedia.org:Vesicular glutamate transporter 1" class="Z3988">
^ ^a ^b "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".

Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH (2000). "Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter". Science. 289 (5481): 957–60. Bibcode:2000Sci...289..957B. doi:10.1126/science.289.5481.957. PMID 10938000.957-60&rft.date=2000&rft_id=info:pmid/10938000&rft_id=info:doi/10.1126/science.289.5481.957&rft_id=info:bibcode/2000Sci...289..957B&rft.aulast=Bellocchio&rft.aufirst=EE&rft.au=Reimer, RJ&rft.au=Fremeau, RT&rft.au=Edwards, RH&rfr_id=info:sid/en.wikipedia.org:Vesicular glutamate transporter 1" class="Z3988">
Takamori S, Rhee JS, Rosenmund C, Jahn R (2000). "Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons". Nature. 407 (6801): 189–94. Bibcode:2000Natur.407..189T. doi:10.1038/35025070. hdl:11858/00-001M-0000-0012-F987-C. PMID 11001057. S2CID 4412622.189-94&rft.date=2000&rft_id=info:hdl/11858/00-001M-0000-0012-F987-C&rft_id=https://api.semanticscholar.org/CorpusID:4412622#id-name=S2CID&rft_id=info:bibcode/2000Natur.407..189T&rft_id=info:pmid/11001057&rft_id=info:doi/10.1038/35025070&rft.aulast=Takamori&rft.aufirst=S&rft.au=Rhee, JS&rft.au=Rosenmund, C&rft.au=Jahn, R&rfr_id=info:sid/en.wikipedia.org:Vesicular glutamate transporter 1" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:Vesicular glutamate transporter 1" class="Z3988">
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki, Y&rft.au=Nishikawa, T&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:Vesicular glutamate transporter 1" class="Z3988">
Eastwood SL, Harrison PJ (2005). "Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons". Schizophrenia Research. 73 (2–3): 159–72. doi:10.1016/j.schres.2004.05.010. PMID 15653259. S2CID 2335413.2–3&rft.pages=159-72&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:2335413#id-name=S2CID&rft_id=info:pmid/15653259&rft_id=info:doi/10.1016/j.schres.2004.05.010&rft.aulast=Eastwood&rft.aufirst=SL&rft.au=Harrison, PJ&rfr_id=info:sid/en.wikipedia.org:Vesicular glutamate transporter 1" class="Z3988">
Alonso-Nanclares L, De Felipe J (2005). "Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex". Neuroscience. 134 (1): 59–68. doi:10.1016/j.neuroscience.2005.03.038. PMID 15961236. S2CID 28633855.59-68&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:28633855#id-name=S2CID&rft_id=info:pmid/15961236&rft_id=info:doi/10.1016/j.neuroscience.2005.03.038&rft.aulast=Alonso-Nanclares&rft.aufirst=L&rft.au=De Felipe, J&rft_id=https://zenodo.org/record/896283&rfr_id=info:sid/en.wikipedia.org:Vesicular glutamate transporter 1" class="Z3988">
Vinatier J, Herzog E, Plamont MA, et al. (2006). "Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis". J. Neurochem. 97 (4): 1111–25. doi:10.1111/j.1471-4159.2006.03821.x. PMID 16606361. S2CID 3133505.1111-25&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:3133505#id-name=S2CID&rft_id=info:pmid/16606361&rft_id=info:doi/10.1111/j.1471-4159.2006.03821.x&rft.aulast=Vinatier&rft.aufirst=J&rft.au=Herzog, E&rft.au=Plamont, MA&rft_id=https://doi.org/10.1111%2Fj.1471-4159.2006.03821.x&rfr_id=info:sid/en.wikipedia.org:Vesicular glutamate transporter 1" class="Z3988">
Almqvist J, Huang Y, Laaksonen A, et al. (2007). "Docking and homology modeling explain inhibition of the human vesicular glutamate transporters". Protein Sci. 16 (9): 1819–29. doi:10.1110/ps.072944707. PMC 2206968. PMID 17660252.1819-29&rft.date=2007&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206968#id-name=PMC&rft_id=info:pmid/17660252&rft_id=info:doi/10.1110/ps.072944707&rft.aulast=Almqvist&rft.aufirst=J&rft.au=Huang, Y&rft.au=Laaksonen, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206968&rfr_id=info:sid/en.wikipedia.org:Vesicular glutamate transporter 1" class="Z3988">

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104888 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070570 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8632143-5] Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na( )-dependent inorganic phosphate cotransporter". J Neurochem. 66 (6): 2227–38. doi:10.1046/j.1471-4159.1996.66062227.x. PMID 8632143. S2CID 23177236.2227-38&rft.date=1996-07&rft_id=https://api.semanticscholar.org/CorpusID:23177236#id-name=S2CID&rft_id=info:pmid/8632143&rft_id=info:doi/10.1046/j.1471-4159.1996.66062227.x&rft.aulast=Ni&rft.aufirst=B&rft.au=Du, Y&rft.au=Wu, X&rft.au=DeHoff, BS&rft.au=Rosteck, PR Jr&rft.au=Paul, SM&rfr_id=info:sid/en.wikipedia.org:Vesicular glutamate transporter 1" class="Z3988">

[pmid10820226-6] Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na( )-dependent inorganic phosphate cotransporter". J Neurochem. 74 (6): 2622–5. doi:10.1046/j.1471-4159.2000.0742622.x. PMID 10820226. S2CID 37857748.2622-5&rft.date=2000-06&rft_id=https://api.semanticscholar.org/CorpusID:37857748#id-name=S2CID&rft_id=info:pmid/10820226&rft_id=info:doi/10.1046/j.1471-4159.2000.0742622.x&rft.aulast=Aihara&rft.aufirst=Y&rft.au=Mashima, H&rft.au=Onda, H&rft.au=Hisano, S&rft.au=Kasuya, H&rft.au=Hori, T&rft.au=Yamada, S&rft.au=Tomura, H&rft.au=Yamada, Y&rft.au=Inoue, I&rft.au=Kojima, I&rft.au=Takeda, J&rft_id=https://doi.org/10.1046%2Fj.1471-4159.2000.0742622.x&rfr_id=info:sid/en.wikipedia.org:Vesicular glutamate transporter 1" class="Z3988">

[entrez-7] "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".

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[7]

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Vesicular glutamate transporter 1

See also

References

Further reading