VPS52

VPS52
Identifiers
Aliases	VPS52, ARE1, SAC2, SACM2L, dJ1033B10.5, GARP complex subunit, VPS52 subunit of GARP complex
External IDs	OMIM: 603443; MGI: 1330304; HomoloGene: 5756; GeneCards: VPS52; OMA:VPS52 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,272,047 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,186,009 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; right uterine tube; ; Pituitary Gland; ; right adrenal cortex; ; left lobe of thyroid gland; ; right hemisphere of cerebellum; ; spleen; ; anterior pituitary; ; left adrenal cortex; ; right ovary;
	Top expressed in
	granulocyte; ; superior frontal gyrus; ; primary visual cortex; ; muscle of thigh; ; lip; ; spermatocyte; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; right kidney; ; Ileal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	syntaxin binding; protein binding;
Cellular component	perinuclear region of cytoplasm; recycling endosome; EARP complex; endosome; Golgi apparatus; endosome membrane; membrane; trans-Golgi network membrane; GARP complex; cytosol;
Biological process	protein transport; ectodermal cell differentiation; embryonic ectodermal digestive tract development; endocytic recycling; lysosomal transport; Golgi to vacuole transport; retrograde transport, endosome to Golgi;
	Sources:Amigo / QuickGO
Orthologs
	6293
	224705
ENSG00000236014; ENSG00000206286; ENSG00000223501; ENSG00000224455; ENSG00000225590;
	ENSG00000223618; ENSG00000228425
	ENSMUSG00000024319
	Q8N1B4
	Q8C754
	NM_001289174; NM_001289175; NM_001289176; NM_022553
	NM_172620; NM_001357329; NM_001357330; NM_001379410; NM_001379411
	NP_001276103; NP_001276104; NP_001276105; NP_072047
	NP_766208; NP_001344258; NP_001344259; NP_001366339; NP_001366340
	Wikidata
View/Edit Human	View/Edit Mouse

Vacuolar protein sorting-associated protein 52 homolog is a protein that in humans is encoded by the VPS52 gene.^[5]^[6]

This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18.^[6]

References

^ ^a ^b ^c ENSG00000206286, ENSG00000223501, ENSG00000224455, ENSG00000225590, ENSG00000223618, ENSG00000228425 GRCh38: Ensembl release 89: ENSG00000236014, ENSG00000206286, ENSG00000223501, ENSG00000224455, ENSG00000225590, ENSG00000223618, ENSG00000228425 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024319 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Walter L, Gunther E (Dec 1998). "Identification of a novel highly conserved gene in the centromeric part of the major histocompatibility complex". Genomics. 52 (3): 298–304. doi:10.1006/geno.1998.5463. PMID 9790748.298-304&rft.date=1998-12&rft_id=info:doi/10.1006/geno.1998.5463&rft_id=info:pmid/9790748&rft.aulast=Walter&rft.aufirst=L&rft.au=Gunther, E&rfr_id=info:sid/en.wikipedia.org:VPS52" class="Z3988">
^ ^a ^b "Entrez Gene: VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.1–2&rft.pages=171-4&rft.date=1994&rft_id=info:doi/10.1016/0378-1119(94)90802-8&rft_id=info:pmid/8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano, S&rfr_id=info:sid/en.wikipedia.org:VPS52" class="Z3988">
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.1–2&rft.pages=149-56&rft.date=1997&rft_id=info:doi/10.1016/S0378-1119(97)00411-3&rft_id=info:pmid/9373149&rft.aulast=Suzuki&rft.aufirst=Y&rft.au=Yoshitomo-Nakagawa, K&rft.au=Maruyama, K&rfr_id=info:sid/en.wikipedia.org:VPS52" class="Z3988">
Stephens R, Horton R, Humphray S, et al. (1999). "Gene organisation, sequence variation and isochore structure at the centromeric boundary of the human MHC". J. Mol. Biol. 291 (4): 789–99. doi:10.1006/jmbi.1999.3004. PMID 10452889.789-99&rft.date=1999&rft_id=info:doi/10.1006/jmbi.1999.3004&rft_id=info:pmid/10452889&rft.aulast=Stephens&rft.aufirst=R&rft.au=Horton, R&rft.au=Humphray, S&rfr_id=info:sid/en.wikipedia.org:VPS52" class="Z3988">
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.aulast=Strausberg&rft.aufirst=RL&rft.au=Feingold, EA&rft.au=Grouse, LH&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:VPS52" class="Z3988">
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.805-11&rft.date=2003&rft_id=info:pmid/14574404&rft_id=info:doi/10.1038/nature02055&rft_id=info:bibcode/2003Natur.425..805M&rft.aulast=Mungall&rft.aufirst=AJ&rft.au=Palmer, SA&rft.au=Sims, SK&rft_id=https://doi.org/10.1038%2Fnature02055&rfr_id=info:sid/en.wikipedia.org:VPS52" class="Z3988">
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.40-5&rft.date=2004&rft_id=info:doi/10.1038/ng1285&rft_id=info:pmid/14702039&rft.aulast=Ota&rft.aufirst=T&rft.au=Suzuki, Y&rft.au=Nishikawa, T&rft_id=https://doi.org/10.1038%2Fng1285&rfr_id=info:sid/en.wikipedia.org:VPS52" class="Z3988">
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.2121-7&rft.date=2004&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928#id-name=PMC&rft_id=info:pmid/15489334&rft_id=info:doi/10.1101/gr.2596504&rft.aulast=Gerhard&rft.aufirst=DS&rft.au=Wagner, L&rft.au=Feingold, EA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928&rfr_id=info:sid/en.wikipedia.org:VPS52" class="Z3988">
Liewen H, Meinhold-Heerlein I, Oliveira V, et al. (2005). "Characterization of the human GARP (Golgi associated retrograde protein) complex". Exp. Cell Res. 306 (1): 24–34. doi:10.1016/j.yexcr.2005.01.022. PMID 15878329.24-34&rft.date=2005&rft_id=info:doi/10.1016/j.yexcr.2005.01.022&rft_id=info:pmid/15878329&rft.aulast=Liewen&rft.aufirst=H&rft.au=Meinhold-Heerlein, I&rft.au=Oliveira, V&rfr_id=info:sid/en.wikipedia.org:VPS52" class="Z3988">

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000206286, ENSG00000223501, ENSG00000224455, ENSG00000225590, ENSG00000223618, ENSG00000228425 GRCh38: Ensembl release 89: ENSG00000236014, ENSG00000206286, ENSG00000223501, ENSG00000224455, ENSG00000225590, ENSG00000223618, ENSG00000228425 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024319 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9790748-5] Walter L, Gunther E (Dec 1998). "Identification of a novel highly conserved gene in the centromeric part of the major histocompatibility complex". Genomics. 52 (3): 298–304. doi:10.1006/geno.1998.5463. PMID 9790748.298-304&rft.date=1998-12&rft_id=info:doi/10.1006/geno.1998.5463&rft_id=info:pmid/9790748&rft.aulast=Walter&rft.aufirst=L&rft.au=Gunther, E&rfr_id=info:sid/en.wikipedia.org:VPS52" class="Z3988">

[entrez-6] "Entrez Gene: VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)".

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VPS52

References

Further reading