Wikipedia

UGT2B15

UDP-glucuronosyltransferase 2B15 is an enzyme that in humans is encoded by the UGT2B15 gene.[5][6]

UGT2B15
Identifiers
AliasesUGT2B15, HLUG4, UDPGT 2B8, UDPGT2B15, UDPGTH3, UGT2B8, UDP glucuronosyltransferase family 2 member B15
External IDsOMIM: 600069; MGI: 1919023; HomoloGene: 133957; GeneCards: UGT2B15; OMA:UGT2B15 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

7366

71773

Ensembl

ENSG00000277132
ENSG00000196620

ENSMUSG00000035836

UniProt

P54855

Q8R084

RefSeq (mRNA)

NM_001076

NM_152811

RefSeq (protein)

NP_001067

NP_690024

Location (UCSC)Chr 4: 68.65 – 68.67 MbChr 5: 87.06 – 87.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B8 demonstrates reactivity with estriol. See UGT2B4 (MIM 600067).[supplied by OMIM][6]

References

edit
  1. ^ a b c ENSG00000196620 GRCh38: Ensembl release 89: ENSG00000277132, ENSG00000196620 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035836 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B (Feb 1995). "Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13". Genomics. 23 (2): 496–9. doi:10.1006/geno.1994.1531. PMID 7835904.496-9&rft.date=1995-02&rft_id=info:doi/10.1006/geno.1994.1531&rft_id=info:pmid/7835904&rft.aulast=Monaghan&rft.aufirst=G&rft.au=Clarke, DJ&rft.au=Povey, S&rft.au=See, CG&rft.au=Boxer, M&rft.au=Burchell, B&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  6. ^ a b "Entrez Gene: UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15".

Further reading

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  • Coffman BL, Tephly TR, Irshaid YM, et al. (1990). "Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase". Arch. Biochem. Biophys. 281 (1): 170–5. doi:10.1016/0003-9861(90)90428-2. PMID 2116769.170-5&rft.date=1990&rft_id=info:doi/10.1016/0003-9861(90)90428-2&rft_id=info:pmid/2116769&rft.aulast=Coffman&rft.aufirst=BL&rft.au=Tephly, TR&rft.au=Irshaid, YM&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Irshaid YM, Tephly TR (1987). "Isolation and purification of two human liver UDP-glucuronosyltransferases". Mol. Pharmacol. 31 (1): 27–34. PMID 3100939.27-34&rft.date=1987&rft_id=info:pmid/3100939&rft.aulast=Irshaid&rft.aufirst=YM&rft.au=Tephly, TR&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Green MD, Clarke DJ, Oturu EM, et al. (1995). "Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols". Arch. Biochem. Biophys. 322 (2): 460–8. doi:10.1006/abbi.1995.1489. PMID 7574722.460-8&rft.date=1995&rft_id=info:doi/10.1006/abbi.1995.1489&rft_id=info:pmid/7574722&rft.aulast=Green&rft.aufirst=MD&rft.au=Clarke, DJ&rft.au=Oturu, EM&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Green MD, Oturu EM, Tephly TR (1995). "Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates". Drug Metab. Dispos. 22 (5): 799–805. PMID 7835232.799-805&rft.date=1995&rft_id=info:pmid/7835232&rft.aulast=Green&rft.aufirst=MD&rft.au=Oturu, EM&rft.au=Tephly, TR&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Chen F, Ritter JK, Wang MG, et al. (1993). "Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms". Biochemistry. 32 (40): 10648–57. doi:10.1021/bi00091a015. PMID 8399210.10648-57&rft.date=1993&rft_id=info:doi/10.1021/bi00091a015&rft_id=info:pmid/8399210&rft.aulast=Chen&rft.aufirst=F&rft.au=Ritter, JK&rft.au=Wang, MG&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Guillemette C, Lévesque E, Beaulieu M, et al. (1997). "Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells". Endocrinology. 138 (7): 2998–3005. doi:10.1210/endo.138.7.5226. PMID 9202245.2998-3005&rft.date=1997&rft_id=info:doi/10.1210/endo.138.7.5226&rft_id=info:pmid/9202245&rft.aulast=Guillemette&rft.aufirst=C&rft.au=Lévesque, E&rft.au=Beaulieu, M&rft_id=https://doi.org/10.1210%2Fendo.138.7.5226&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Lévesque E, Beaulieu M, Green MD, et al. (1997). "Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene". Pharmacogenetics. 7 (4): 317–25. doi:10.1097/00008571-199708000-00007. PMID 9295060.317-25&rft.date=1997&rft_id=info:doi/10.1097/00008571-199708000-00007&rft_id=info:pmid/9295060&rft.aulast=Lévesque&rft.aufirst=E&rft.au=Beaulieu, M&rft.au=Green, MD&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Strassburg CP, Strassburg A, Nguyen N, et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus". Biochem. J. 338 (2): 489–98. doi:10.1042/0264-6021:3380489. PMC 1220077. PMID 10024527.489-98&rft.date=1999&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1220077#id-name=PMC&rft_id=info:pmid/10024527&rft_id=info:doi/10.1042/0264-6021:3380489&rft.aulast=Strassburg&rft.aufirst=CP&rft.au=Strassburg, A&rft.au=Nguyen, N&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1220077&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Tchernof A, Lévesque E, Beaulieu M, et al. (1999). "Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method". Clin. Endocrinol. 50 (5): 637–42. doi:10.1046/j.1365-2265.1999.00709.x. PMID 10468930. S2CID 43030627.637-42&rft.date=1999&rft_id=https://api.semanticscholar.org/CorpusID:43030627#id-name=S2CID&rft_id=info:pmid/10468930&rft_id=info:doi/10.1046/j.1365-2265.1999.00709.x&rft.aulast=Tchernof&rft.aufirst=A&rft.au=Lévesque, E&rft.au=Beaulieu, M&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine". J. Biol. Chem. 275 (46): 36164–71. doi:10.1074/jbc.M002180200. PMID 10748067.36164-71&rft.date=2000&rft_id=info:doi/10.1074/jbc.M002180200&rft_id=info:pmid/10748067&rft.aulast=Strassburg&rft.aufirst=CP&rft.au=Kneip, S&rft.au=Topp, J&rft_id=https://doi.org/10.1074%2Fjbc.M002180200&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Gsur A, Preyer M, Haidinger G, et al. (2002). "A polymorphism in the UDP-Glucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk". Cancer Epidemiol. Biomarkers Prev. 11 (5): 497–8. PMID 12010866.497-8&rft.date=2002&rft_id=info:pmid/12010866&rft.aulast=Gsur&rft.aufirst=A&rft.au=Preyer, M&rft.au=Haidinger, G&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Iida A, Saito S, Sekine A, et al. (2002). "Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8". J. Hum. Genet. 47 (10): 505–10. doi:10.1007/s100380200075. PMID 12376738.505-10&rft.date=2002&rft_id=info:doi/10.1007/s100380200075&rft_id=info:pmid/12376738&rft.aulast=Iida&rft.aufirst=A&rft.au=Saito, S&rft.au=Sekine, A&rft_id=https://doi.org/10.1007%2Fs100380200075&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Court MH, Duan SX, Guillemette C, et al. (2003). "Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9". Drug Metab. Dispos. 30 (11): 1257–65. doi:10.1124/dmd.30.11.1257. PMID 12386133.1257-65&rft.date=2003&rft_id=info:doi/10.1124/dmd.30.11.1257&rft_id=info:pmid/12386133&rft.aulast=Court&rft.aufirst=MH&rft.au=Duan, SX&rft.au=Guillemette, C&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Kanaya J, Takashima M, Koh E, Namiki M (2003). "Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expression". Asian J. Androl. 5 (1): 9–13. PMID 12646996.9-13&rft.date=2003&rft_id=info:pmid/12646996&rft.aulast=Kanaya&rft.aufirst=J&rft.au=Takashima, M&rft.au=Koh, E&rft.au=Namiki, M&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Zhang JY, Zhan J, Cook CS, et al. (2003). "Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism". Drug Metab. Dispos. 31 (5): 652–8. doi:10.1124/dmd.31.5.652. PMID 12695355. S2CID 23434477.652-8&rft.date=2003&rft_id=https://api.semanticscholar.org/CorpusID:23434477#id-name=S2CID&rft_id=info:pmid/12695355&rft_id=info:doi/10.1124/dmd.31.5.652&rft.aulast=Zhang&rft.aufirst=JY&rft.au=Zhan, J&rft.au=Cook, CS&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Tomboc M, Witchel SF (2003). "Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism". J. Pediatr. Endocrinol. Metab. 16 (5): 719–26. doi:10.1515/jpem.2003.16.5.719. PMID 12880121. S2CID 32217321.719-26&rft.date=2003&rft_id=https://api.semanticscholar.org/CorpusID:32217321#id-name=S2CID&rft_id=info:pmid/12880121&rft_id=info:doi/10.1515/jpem.2003.16.5.719&rft.aulast=Tomboc&rft.aufirst=M&rft.au=Witchel, SF&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Court MH, Hao Q, Krishnaswamy S, et al. (2005). "UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver". J. Pharmacol. Exp. Ther. 310 (2): 656–65. doi:10.1124/jpet.104.067660. PMID 15044558. S2CID 8636464.656-65&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:8636464#id-name=S2CID&rft_id=info:pmid/15044558&rft_id=info:doi/10.1124/jpet.104.067660&rft.aulast=Court&rft.aufirst=MH&rft.au=Hao, Q&rft.au=Krishnaswamy, S&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Toide K, Umeda S, Yamazaki H, et al. (2005). "A major genotype in UDP-glucuronosyltransferase 2B15". Drug Metab. Pharmacokinet. 17 (2): 164–6. doi:10.2133/dmpk.17.164. PMID 15618667.164-6&rft.date=2005&rft_id=info:doi/10.2133/dmpk.17.164&rft_id=info:pmid/15618667&rft.aulast=Toide&rft.aufirst=K&rft.au=Umeda, S&rft.au=Yamazaki, H&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
  • Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). "Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium". Endocr. Res. 30 (4): 717–25. doi:10.1081/ERC-200044014. PMID 15666817. S2CID 10971899.717-25&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:10971899#id-name=S2CID&rft_id=info:pmid/15666817&rft_id=info:doi/10.1081/ERC-200044014&rft.aulast=Chouinard&rft.aufirst=S&rft.au=Pelletier, G&rft.au=Bélanger, A&rft.au=Barbier, O&rfr_id=info:sid/en.wikipedia.org:UGT2B15" class="Z3988">
 

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