In enzymology, an UDP-N-acetylglucosamine 6-dehydrogenase (EC 1.1.1.136) is an enzyme that catalyzes the chemical reaction
| UDP-N-acetylglucosamine 6-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.136 | ||||||||
| CAS no. | 9054-83-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- UDP-N-acetyl-D-glucosamine 2 NAD H2O UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate 2 NADH 2 H
The 3 substrates of this enzyme are UDP-N-acetyl-D-glucosamine, NAD , and H2O, whereas its 3 products are UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate, NADH, and H .
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:NAD 6-oxidoreductase. Other names in common use include uridine diphosphoacetylglucosamine dehydrogenase, UDP-acetylglucosamine dehydrogenase, UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase, and UDP-GlcNAc dehydrogenase. This enzyme participates in aminosugars metabolism.
References
edit- Fan DF, John CE, Zalitis J, Feingold DS (1969). "UDPacetylglucosamine dehydrogenase from Achromobacter georgiopolitanum". Arch. Biochem. Biophys. 135 (1): 45–9. doi:10.1016/0003-9861(69)90514-1. PMID 4312076.45-9&rft.date=1969&rft_id=info:doi/10.1016/0003-9861(69)90514-1&rft_id=info:pmid/4312076&rft.aulast=Fan&rft.aufirst=DF&rft.au=John, CE&rft.au=Zalitis, J&rft.au=Feingold, DS&rfr_id=info:sid/en.wikipedia.org:UDP-N-acetylglucosamine 6-dehydrogenase" class="Z3988">
