UBE2H

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.

UBE2H
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Z5D
Identifiers
Aliases	UBE2H, E2-20K, GID3, UBC8, UBCH, UBCH2, ubiquitin conjugating enzyme E2 H
External IDs	OMIM: 601082; MGI: 104632; HomoloGene: 103894; GeneCards: UBE2H; OMA:UBE2H - orthologs
EC number	2.3.2.24
Gene location (Human) Chr. Chromosome 7 (human) Band 7q32.2 Start 129,830,732 bp End 129,952,960 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 A3.3|6 12.52 cM Start 30,211,288 bp End 30,304,538 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte right adrenal cortex epithelium of colon saphenous vein internal globus pallidus Skeletal muscle tissue of biceps brachii amniotic fluid islet of Langerhans left adrenal gland caput epididymis Top expressed in blood retinal pigment epithelium Rostral migratory stream tibiofemoral joint substantia nigra medullary collecting duct ascending aorta ciliary body condyle fossa More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein binding ATP binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin-protein transferase activity Cellular component cytoplasm cytosol Biological process protein K48-linked ubiquitination ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process protein K11-linked ubiquitination protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7328 22214 Ensembl ENSG00000186591 ENSMUSG00000039159 UniProt P62256 P62257 RefSeq (mRNA) NM_001202498 NM_003344 NM_182697 NM_001169576 NM_001169577 NM_009459 RefSeq (protein) NP_001189427 NP_003335 NP_874356 NP_003335.1 NP_001163047 NP_001163048 NP_033485 Location (UCSC) Chr 7: 129.83 – 129.95 Mb Chr 6: 30.21 – 30.3 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

Further reading

• Wefes I, Mastrandrea LD, Haldeman M, et al. (1995). "Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation". Proc. Natl. Acad. Sci. U.S.A. 92 (11): 4982–6. Bibcode:1995PNAS...92.4982W. doi:10.1073/pnas.92.11.4982. PMC 41831. PMID 7761435.
• Kaiser P, Mandl S, Schweiger M, Schneider R (1996). "Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2". FEBS Lett. 377 (2): 193–6. Bibcode:1995FEBSL.377..193K. doi:10.1016/0014-5793(95)01323-7. PMID 8543049. S2CID 24431321.
• Hayashida S, Yamasaki K, Asada Y, et al. (2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948. S2CID 19637860.
• Vourc'h P, Martin I, Bonnet-Brilhault F, et al. (2005). "Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder". Psychiatr. Genet. 13 (4): 221–5. doi:10.1097/00041444-200312000-00005. PMID 14639049. S2CID 25469223.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
• Bartee E, Mansouri M, Hovey Nerenberg BT, et al. (2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J. Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
• Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID 15107846. S2CID 39773935.
• Kim HJ, Chong KH, Kang SW, et al. (2005). "Identification of cyclophilin A as a CD99-binding protein by yeast two-hybrid screening". Immunol. Lett. 95 (2): 155–9. doi:10.1016/j.imlet.2004.07.001. PMID 15388255.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.