Tropine acyltransferase (EC 2.3.1.185, tropine:acyl-CoA transferase, acetyl-CoA:tropan-3-ol acyltransferase, tropine acetyltransferase, tropine tigloyltransferase, TAT) is an enzyme with systematic name acyl-CoA:tropine O-acyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
| Tropine acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.185 | ||||||||
| CAS no. | 162535-29-7&title= 138440-79-6, 162535-29-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme exhibits absolute specificity for the endo/3alpha configuration found in tropine as pseudotropine.
References
edit- ^ Robins RJ, Bachmann P, Robinson T, Rhodes MJ, Yamada Y (November 1991). "The formation of 3 alpha- and 3 beta-acetoxytropanes by Datura stramonium transformed root cultures involves two acetyl-CoA-dependent acyltransferases". FEBS Letters. 292 (1–2): 293–7. doi:10.1016/0014-5793(91)80887-9. PMID 1959620.1–2&rft.pages=293-7&rft.date=1991-11&rft_id=info:doi/10.1016/0014-5793(91)80887-9&rft_id=info:pmid/1959620&rft.aulast=Robins&rft.aufirst=RJ&rft.au=Bachmann, P&rft.au=Robinson, T&rft.au=Rhodes, MJ&rft.au=Yamada, Y&rft_id=https://doi.org/10.1016%2F0014-5793%2891%2980887-9&rfr_id=info:sid/en.wikipedia.org:Tropine acyltransferase" class="Z3988">
- ^ Robins, R.J.; Bachmann,P.; Peerless, A.C.J.; Rabot, S. (1994). "Esterification reactions in the biosynthesis of tropane alkaloids in transformed root cultures". Plant Cell Tissue Organ Cult. 38: 241–247. doi:10.1007/bf00033883.241-247&rft.date=1994&rft_id=info:doi/10.1007/bf00033883&rft.au=Robins, R.J.&rft.au=Bachmann,P.&rft.au=Peerless, A.C.J.&rft.au=Rabot, S.&rfr_id=info:sid/en.wikipedia.org:Tropine acyltransferase" class="Z3988">
- ^ Boswell HD, Dräger B, McLauchlan WR, Portsteffen A, Robins DJ, Robins RJ, Walton NJ (November 1999). "Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura". Phytochemistry. 52 (5): 871–8. doi:10.1016/S0031-9422(99)00293-9. PMID 10626376.871-8&rft.date=1999-11&rft_id=info:doi/10.1016/S0031-9422(99)00293-9&rft_id=info:pmid/10626376&rft.aulast=Boswell&rft.aufirst=HD&rft.au=Dräger, B&rft.au=McLauchlan, WR&rft.au=Portsteffen, A&rft.au=Robins, DJ&rft.au=Robins, RJ&rft.au=Walton, NJ&rfr_id=info:sid/en.wikipedia.org:Tropine acyltransferase" class="Z3988">
- ^ Li R, Reed DW, Liu E, Nowak J, Pelcher LE, Page JE, Covello PS (May 2006). "Functional genomic analysis of alkaloid biosynthesis in Hyoscyamus niger reveals a cytochrome P450 involved in littorine rearrangement". Chemistry & Biology. 13 (5): 513–20. doi:10.1016/j.chembiol.2006.03.005. PMID 16720272.513-20&rft.date=2006-05&rft_id=info:doi/10.1016/j.chembiol.2006.03.005&rft_id=info:pmid/16720272&rft.aulast=Li&rft.aufirst=R&rft.au=Reed, DW&rft.au=Liu, E&rft.au=Nowak, J&rft.au=Pelcher, LE&rft.au=Page, JE&rft.au=Covello, PS&rft_id=https://doi.org/10.1016%2Fj.chembiol.2006.03.005&rfr_id=info:sid/en.wikipedia.org:Tropine acyltransferase" class="Z3988">
External links
edit- Tropine acyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
