Tregalizumab is an immunomodulator.[1] It is also known as BT-061. Tregalizumab binds to domain 2 of CD4,[2] and activates Regulatory T cells (Tregs).[3]
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized |
| Target | CD4 |
| Clinical data | |
| Other names | BT-061 |
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References
edit- ^ World Health Organization (2010). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 104" (PDF). WHO Drug Information. 24 (4).
- ^ Helling B, König M, Dälken B, Engling A, Krömer W, Heim K, et al. (April 2015). "A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway". Immunology and Cell Biology. 93 (4): 396–405. doi:10.1038/icb.2014.102. PMC 4407014. PMID 25512343.396-405&rft.date=2015-04&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407014#id-name=PMC&rft_id=info:pmid/25512343&rft_id=info:doi/10.1038/icb.2014.102&rft.aulast=Helling&rft.aufirst=B&rft.au=König, M&rft.au=Dälken, B&rft.au=Engling, A&rft.au=Krömer, W&rft.au=Heim, K&rft.au=Wallmeier, H&rft.au=Haas, J&rft.au=Wildemann, B&rft.au=Fritz, B&rft.au=Jonuleit, H&rft.au=Kubach, J&rft.au=Dingermann, T&rft.au=Radeke, HH&rft.au=Osterroth, F&rft.au=Uherek, C&rft.au=Czeloth, N&rft.au=Schüttrumpf, J&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407014&rfr_id=info:sid/en.wikipedia.org:Tregalizumab" class="Z3988">
- ^ König M, Rharbaoui F, Aigner S, Dälken B, Schüttrumpf J (Jan 2016). "Tregalizumab - A Monoclonal Antibody to Target Regulatory T Cells". Frontiers in Immunology. 7: 11. doi:10.3389/fimmu.2016.00011. PMC 4724712. PMID 26834751.
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