Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.[5]
| tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TIE1 | ||||||
| Alt. symbols | TIE, JTK14 | ||||||
| NCBI gene | 7075 | ||||||
| HGNC | 11809 | ||||||
| OMIM | 600222 | ||||||
| RefSeq | NM_005424 | ||||||
| UniProt | P35590 | ||||||
| Other data | |||||||
| EC number | 2.7.1.112 | ||||||
| Locus | Chr. 1 p34-p33 | ||||||
| |||||||
Function
editTIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells[6] and platelets.[7] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.[8]
See also
editReferences
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000066056 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033191 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Molecular and Cellular Biology. 12 (4): 1698–707. doi:10.1128/mcb.12.4.1698. PMC 369613. PMID 1312667.1698-707&rft.date=1992-04&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC369613#id-name=PMC&rft_id=info:pmid/1312667&rft_id=info:doi/10.1128/mcb.12.4.1698&rft.aulast=Partanen&rft.aufirst=J&rft.au=Armstrong, E&rft.au=Mäkelä, TP&rft.au=Korhonen, J&rft.au=Sandberg, M&rft.au=Renkonen, R&rft.au=Knuutila, S&rft.au=Huebner, K&rft.au=Alitalo, K&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC369613&rfr_id=info:sid/en.wikipedia.org:TIE1" class="Z3988">
- ^ Rodewald HR, Sato TN (January 1996). "Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells". Oncogene. 12 (2): 397–404. PMID 8570217.397-404&rft.date=1996-01&rft_id=info:pmid/8570217&rft.aulast=Rodewald&rft.aufirst=HR&rft.au=Sato, TN&rfr_id=info:sid/en.wikipedia.org:TIE1" class="Z3988">
- ^ Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets". Journal of Vascular Research. 37 (6): 437–42. doi:10.1159/000054075. PMID 11146396. S2CID 43509019.437-42&rft.date=2000&rft_id=https://api.semanticscholar.org/CorpusID:43509019#id-name=S2CID&rft_id=info:pmid/11146396&rft_id=info:doi/10.1159/000054075&rft.aulast=Tsiamis&rft.aufirst=AC&rft.au=Hayes, P&rft.au=Box, H&rft.au=Goodall, AH&rft.au=Bell, PR&rft.au=Brindle, NP&rfr_id=info:sid/en.wikipedia.org:TIE1" class="Z3988">
- ^ Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). "Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules". Biochemical and Biophysical Research Communications. 371 (3): 475–9. doi:10.1016/j.bbrc.2008.04.091. PMID 18448073.475-9&rft.date=2008-07&rft_id=info:doi/10.1016/j.bbrc.2008.04.091&rft_id=info:pmid/18448073&rft.aulast=Chan&rft.aufirst=B&rft.au=Yuan, HT&rft.au=Ananth Karumanchi, S&rft.au=Sukhatme, VP&rfr_id=info:sid/en.wikipedia.org:TIE1" class="Z3988">
External links
edit- Receptor, TIE-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
