Talk:Dendritic cell

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Untitled

Axel,

"Dendritic cell" looks good to me, though there are 2 places where I wondered a bit:

• The article says "Dendritic cells constantly sample the surroundings for viruses and bacteria": to me, this makes dendritic cells sound 'smarter' than they are. They respond to foreign, or non-self, proteins, they don't know if it's viral or bacterial or anything other than non-self. But this may be more obscure than the way you have it.
• I don't know that I'd call helper T-cells the HIV virus's "true host": HIV infects a lot of cells, though CD-4 cells are a special target and a major means of increasing the level of infection.

As for your specific questions:

• I don't know how motile they are in tissue. I'd BET they move around a bit, but I don't KNOW that this is the case.
• the short answer is they develop from monocytes - they seem to be CD14 monocytes. The long answer is that this is an area of active research and the exact understanding of how dendritic cells develop is likely to change as further research is done. But I think the general idea that once a cell is a macrophage it's too late for it to become a dendritic cell is sound. -- Someone else 22:59 Nov 18, 2002 (UTC)

Mature monocytes can differentiate into dendritic cells. These monocyte-derived dendritic cells can be generated ex vivo by culture of macrophages with GM-CSF and IL-4. Incidently, there is no absolute requirement for IL-4 in the generation of monocyte-derived dendritic cells.

Also, it is incorrect to imply that dendritic cells respond only to non-self proteins - they are equally capable of presenting self-epitopes, either MHC class I-restricted or MHC class II-restricted epitopes. --Sarah Morwood 21:06, 9 October 2007 (UTC)

New subtitles to make the article more organized

Do you think we should split the article into sections to make it easier to read?? Also, i think we should add in which cytokines activate the dendritic cells to migrate, eg. IL-1 and TNF produced by macrophages when they encounter microbes. (REFRENCE: Basic Immunology Functions & Disorders of the Immune System 2nd Edition 2004 By AK Abbas et al.) --LowLifer 06:29, 15 October 2005 (UTC)

sensing viruses or bacteria

Actually, with due respect, we think the dendritic cells do "know" whether they are sensing viruses or bacteria (or for that matter fungi etc) because they have Toll-like receptors on their surface which help them 'recognise' different components of different types of organism, e.g. cell wall components of different types of bacteria. [Incidentally, this is my first ever entry and I hope it works!] -- comment by 163.1.212.43, 5/3/2006

Thank you for your suggestion! When you feel an article needs improvement, please feel free to make whatever changes you feel are needed. Wikipedia is a wiki, so anyone can edit any article by simply following the Edit this page link at the top. You don't even need to log in! (Although there are some reasons why you might like to...) The Wikipedia community encourages you to be bold. Don't worry too much about making honest mistakes—they're likely to be found and corrected quickly. If you're not sure how editing works, check out how to edit a page, or use the sandbox to try out your editing skills. New contributors are always welcome. --Arcadian 16:17, 3 May 2006 (UTC)

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Follicular dendritic cells are not Atigen presenting cells (APCs) They are MHC II negative and should not be included in this article

I agree that Follicular Dendritic cells have nothing to do with antigen presenting cells and should be removed.

I agree that FDCs fall outside the scope of this article, but has it occurred to anyone that there's no separate entry for an FDC elsewhere? I suppose this should be the cue to start one, even if only a stub. Jbarin 06:21, 8 May 2007 (UTC)

We've had one since March at follicular dendritic cells, but it certainly needs expanding. --Arcadian 02:42, 21 May 2007 (UTC)

A note about the videos

There appears to be a bug (reported) in the Wikimedia Player that returns an error when "Watch in browser" is attempted from the link in the article. However, the Watch-in-browser (Play-in-browser) feature does appear to work from the link provided on the image description page (i.e. the "(file info)" link).--DO11.10 18:37, 21 June 2007 (UTC)

IKDCs

Is there an article about IKDCs? Could we get an item in ==See also== that says "IKDCs, which are not considered dendritic cells"? WhatamIdoing (talk) 17:42, 26 April 2008 (UTC)

References Required

This article is under referenced, many of the paragraphs don't have any citations. Please add citations. Aqua112233 (talk) 11:00, 21 February 2011 (UTC)

Plasmacytoid dendritic cell is lymphoid dendritic cell?

In the whole article there is no explanation if the Plasmacytoid dendritic cells are Lymphoid DCs. I understand that you list 3 types: mDC, pDC and FDC. If the pDC is not lymphoid DC then that should be cleared too. — Preceding unsigned comment added by 24.248.198.18 (talk) 19:01, 15 August 2011 (UTC)

I agree. You should distinguish between pDC and lymphoid DC (or you should say they are the same). It's a bit confusing.--Miguelferig (talk) 17:36, 25 December 2011 (UTC)

pDCs are both derived from Lymphoid and myloid origins, see miriam merad's annual reveiws paper on the topic. Ellemrei (talk) 01:43, 10 October 2014 (UTC)

Mice Dendritic Cells Subsets

Hello all, I was reviewing the Dendritic cell subsets in mice and found almost no information regarding them. This is an area in which I am fairly up to date with and was hoping to expand on that section.

Mouse (Murine)

Murine DCs can be classified into two primary groups, plasmacytoid dendritic cells (pDCs), and the conventional dendritic cells (cDCs). Murine pDCs, are commonly characterised by the of the expression of bone stromal marker 2 which is binded by the mPDCA-1 antibody. Murine cDCs, are typically defined based off of the tissue which they are found in; lymphoid or non-lymphoid tissue, as the markers used for identification vary depending on the location of the cDCs. cDCs are commonly described by the markers CD11c, however CD11c does not unambiguously define DCs within the mouse, and the subsets can be further defined using, CD8, CD11b, CD103 antibodies.

Also I noticed that in the page that myeloid vs plasmacytoid DCs was used as the standard demarcation between the two large divisions within dendritic cells, however in most of my readings I find that conventional DCs is much more common, could we change myeloid to conventional?

Ellemrei (talk) 18:29, 14 September 2014 (UTC)

References

Assessment comment

The comment(s) below were originally left at Talk:Dendritic cell/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

It is not true that the term Dendritic cell was coined by Ralph Steinmen and Zanvil Cohn. It was coined by Becker SW in 1927(I am not sure if S is Stanley or not). Dr. Steinman discovered the Dendritic cells in the peripheral lymphoid organs of mice. That is to Dr. Steinman's credit. Dendritic cell is an antigen presenting cell and belongs in that classification.

Last edited at 18:54, 12 March 2007 (UTC). Substituted at 13:12, 29 April 2016 (UTC)