In enzymology, a tabersonine 16-O-methyltransferase (EC 2.1.1.94) is an enzyme that catalyzes the chemical reaction
| 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.94 | ||||||||
| CAS no. | 100984-95-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- S-adenosyl-L-methionine 16-hydroxytabersonine S-adenosyl-L-homocysteine 16-methoxytabersonine
Thus, the two substrates of this enzyme are S-adenosyl methionine and 16-hydroxytabersonine, whereas its two products are S-adenosylhomocysteine and 16-methoxytabersonine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase. Other names in common use include 11-demethyl-17-deacetylvindoline 11-methyltransferase, 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase, S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline, and 11-O-methyltransferase. This enzyme participates in terpene indole and ipecac alkaloid biosynthesis.
References
edit- Foucher AL, McIntosh A, Douce G, Wastling J, Tait A, Turner CM (2006). "A proteomic analysis of arsenical drug resistance in Trypanosoma brucei". Proteomics. 6 (9): 2726–32. doi:10.1002/pmic.200500419. PMID 16526094.2726-32&rft.date=2006&rft_id=info:doi/10.1002/pmic.200500419&rft_id=info:pmid/16526094&rft.aulast=Foucher&rft.aufirst=AL&rft.au=McIntosh, A&rft.au=Douce, G&rft.au=Wastling, J&rft.au=Tait, A&rft.au=Turner, CM&rfr_id=info:sid/en.wikipedia.org:Tabersonine 16-O-methyltransferase" class="Z3988">
- Fahn W, Laussermair E, Deus-Neumann B, Stockigt J (1985). "Late enzymes of vindoline biosynthesis S-Adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methylase and unspecific acetylesterase". Plant Cell Rep. 4: 337–340. doi:10.1007/bf00269893.337-340&rft.date=1985&rft_id=info:doi/10.1007/bf00269893&rft.aulast=Fahn&rft.aufirst=W&rft.au=Laussermair, E&rft.au=Deus-Neumann, B&rft.au=Stockigt, J&rfr_id=info:sid/en.wikipedia.org:Tabersonine 16-O-methyltransferase" class="Z3988">
