Wikipedia

Stratifin

Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the SFN gene in humans.[5][6] The protein is named for its presence in stratified epithelial cells.[5]

SFN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSFN, YWHAS, Stratifin
External IDsOMIM: 601290; MGI: 1891831; HomoloGene: 4475; GeneCards: SFN; OMA:SFN - orthologs
Orthologs
SpeciesHumanMouse
Entrez

2810

58638

Ensembl

ENSG00000175793

ENSMUSG00000047281

UniProt

P31947

O70456

RefSeq (mRNA)

NM_006142

NM_018754

RefSeq (protein)

NP_006133

NP_061224

Location (UCSC)Chr 1: 26.86 – 26.86 MbChr 4: 133.33 – 133.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

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Stratifin has been shown to interact with PLK4,[7] ERRFI1,[8] MARK3,[7][8] JUB[8] and YWHAG.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175793 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047281 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Leffers H, Madsen P, Rasmussen HH, Honoré B, Andersen AH, Walbum E, Vandekerckhove J, Celis JE (June 1993). "Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway". Journal of Molecular Biology. 231 (4): 982–98. doi:10.1006/jmbi.1993.1346. PMID 8515476.982-98&rft.date=1993-06&rft_id=info:doi/10.1006/jmbi.1993.1346&rft_id=info:pmid/8515476&rft.aulast=Leffers&rft.aufirst=H&rft.au=Madsen,+P&rft.au=Rasmussen,+HH&rft.au=Honoré,+B&rft.au=Andersen,+AH&rft.au=Walbum,+E&rft.au=Vandekerckhove,+J&rft.au=Celis,+JE&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  6. ^ "Entrez Gene: SFN stratifin".
  7. ^ a b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.1173-8&rft.date=2005-10&rft_id=info:doi/10.1038/nature04209&rft_id=https://api.semanticscholar.org/CorpusID:4427026#id-name=S2CID&rft_id=info:pmid/16189514&rft_id=info:bibcode/2005Natur.437.1173R&rft.aulast=Rual&rft.aufirst=JF&rft.au=Venkatesan,+K&rft.au=Hao,+T&rft.au=Hirozane-Kishikawa,+T&rft.au=Dricot,+A&rft.au=Li,+N&rft.au=Berriz,+GF&rft.au=Gibbons,+FD&rft.au=Dreze,+M&rft.au=Ayivi-Guedehoussou,+N&rft.au=Klitgord,+N&rft.au=Simon,+C&rft.au=Boxem,+M&rft.au=Milstein,+S&rft.au=Rosenberg,+J&rft.au=Goldberg,+DS&rft.au=Zhang,+LV&rft.au=Wong,+SL&rft.au=Franklin,+G&rft.au=Li,+S&rft.au=Albala,+JS&rft.au=Lim,+J&rft.au=Fraughton,+C&rft.au=Llamosas,+E&rft.au=Cevik,+S&rft.au=Bex,+C&rft.au=Lamesch,+P&rft.au=Sikorski,+RS&rft.au=Vandenhaute,+J&rft.au=Zoghbi,+HY&rft.au=Smolyar,+A&rft.au=Bosak,+S&rft.au=Sequerra,+R&rft.au=Doucette-Stamm,+L&rft.au=Cusick,+ME&rft.au=Hill,+DE&rft.au=Roth,+FP&rft.au=Vidal,+M&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  8. ^ a b c d Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.785-95&rft.date=2005-06&rft_id=info:doi/10.1074/mcp.M500021-MCP200&rft_id=info:pmid/15778465&rft.aulast=Benzinger&rft.aufirst=A&rft.au=Muster,+N&rft.au=Koch,+HB&rft.au=Yates,+JR&rft.au=Hermeking,+H&rft_id=https://doi.org/10.1074%2Fmcp.M500021-MCP200&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">

Further reading

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  • Hermeking H (January 2005). "Extracellular 14-3-3sigma protein: a potential mediator of epithelial-mesenchymal interactions". The Journal of Investigative Dermatology. 124 (1): ix–x. doi:10.1111/j.0022-202X.2004.23534.x. PMID 15654940.ix-x&rft.date=2005-01&rft_id=info:doi/10.1111/j.0022-202X.2004.23534.x&rft_id=info:pmid/15654940&rft.aulast=Hermeking&rft.aufirst=H&rft_id=https://doi.org/10.1111%2Fj.0022-202X.2004.23534.x&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Mhawech P (April 2005). "14-3-3 proteins--an update". Cell Research. 15 (4): 228–36. doi:10.1038/sj.cr.7290291. PMID 15857577.228-36&rft.date=2005-04&rft_id=info:doi/10.1038/sj.cr.7290291&rft_id=info:pmid/15857577&rft.aulast=Mhawech&rft.aufirst=P&rft_id=https://doi.org/10.1038%2Fsj.cr.7290291&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Lodygin D, Hermeking H (April 2005). "The role of epigenetic inactivation of 14-3-3sigma in human cancer". Cell Research. 15 (4): 237–46. doi:10.1038/sj.cr.7290292. PMID 15857578.237-46&rft.date=2005-04&rft_id=info:doi/10.1038/sj.cr.7290292&rft_id=info:pmid/15857578&rft.aulast=Lodygin&rft.aufirst=D&rft.au=Hermeking,+H&rft_id=https://doi.org/10.1038%2Fsj.cr.7290292&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (December 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.960-9&rft.date=1992-12&rft_id=https://api.semanticscholar.org/CorpusID:41855774#id-name=S2CID&rft_id=info:pmid/1286667&rft_id=info:doi/10.1002/elps.11501301199&rft.aulast=Rasmussen&rft.aufirst=HH&rft.au=van+Damme,+J&rft.au=Puype,+M&rft.au=Gesser,+B&rft.au=Celis,+JE&rft.au=Vandekerckhove,+J&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Prasad GL, Valverius EM, McDuffie E, Cooper HL (August 1992). "Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells". Cell Growth & Differentiation. 3 (8): 507–13. PMID 1390337.507-13&rft.date=1992-08&rft_id=info:pmid/1390337&rft.aulast=Prasad&rft.aufirst=GL&rft.au=Valverius,+EM&rft.au=McDuffie,+E&rft.au=Cooper,+HL&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Hermeking H, Lengauer C, Polyak K, He TC, Zhang L, Thiagalingam S, Kinzler KW, Vogelstein B (December 1997). "14-3-3sigma is a p53-regulated inhibitor of G2/M progression". Molecular Cell. 1 (1): 3–11. doi:10.1016/S1097-2765(00)80002-7. PMID 9659898.3-11&rft.date=1997-12&rft_id=info:doi/10.1016/S1097-2765(00)80002-7&rft_id=info:pmid/9659898&rft.aulast=Hermeking&rft.aufirst=H&rft.au=Lengauer,+C&rft.au=Polyak,+K&rft.au=He,+TC&rft.au=Zhang,+L&rft.au=Thiagalingam,+S&rft.au=Kinzler,+KW&rft.au=Vogelstein,+B&rft_id=https://doi.org/10.1016%2FS1097-2765%2800%2980002-7&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B (October 1999). "14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage". Nature. 401 (6753): 616–20. Bibcode:1999Natur.401..616C. doi:10.1038/44188. PMID 10524633. S2CID 4413753.616-20&rft.date=1999-10&rft_id=info:doi/10.1038/44188&rft_id=https://api.semanticscholar.org/CorpusID:4413753#id-name=S2CID&rft_id=info:pmid/10524633&rft_id=info:bibcode/1999Natur.401..616C&rft.aulast=Chan&rft.aufirst=TA&rft.au=Hermeking,+H&rft.au=Lengauer,+C&rft.au=Kinzler,+KW&rft.au=Vogelstein,+B&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Laronga C, Yang HY, Neal C, Lee MH (July 2000). "Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression". The Journal of Biological Chemistry. 275 (30): 23106–12. doi:10.1074/jbc.M905616199. PMID 10767298.23106-12&rft.date=2000-07&rft_id=info:doi/10.1074/jbc.M905616199&rft_id=info:pmid/10767298&rft.aulast=Laronga&rft.aufirst=C&rft.au=Yang,+HY&rft.au=Neal,+C&rft.au=Lee,+MH&rft_id=https://doi.org/10.1074%2Fjbc.M905616199&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Samuel T, Weber HO, Rauch P, Verdoodt B, Eppel JT, McShea A, Hermeking H, Funk JO (November 2001). "The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax". The Journal of Biological Chemistry. 276 (48): 45201–6. doi:10.1074/jbc.M106427200. PMID 11574543.45201-6&rft.date=2001-11&rft_id=info:doi/10.1074/jbc.M106427200&rft_id=info:pmid/11574543&rft.aulast=Samuel&rft.aufirst=T&rft.au=Weber,+HO&rft.au=Rauch,+P&rft.au=Verdoodt,+B&rft.au=Eppel,+JT&rft.au=McShea,+A&rft.au=Hermeking,+H&rft.au=Funk,+JO&rft_id=https://doi.org/10.1074%2Fjbc.M106427200&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Johnson BA, Stehn JR, Yaffe MB, Blackwell TK (May 2002). "Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms". The Journal of Biological Chemistry. 277 (20): 18029–36. doi:10.1074/jbc.M110465200. PMID 11886850.18029-36&rft.date=2002-05&rft_id=info:doi/10.1074/jbc.M110465200&rft_id=info:pmid/11886850&rft.aulast=Johnson&rft.aufirst=BA&rft.au=Stehn,+JR&rft.au=Yaffe,+MB&rft.au=Blackwell,+TK&rft_id=https://doi.org/10.1074%2Fjbc.M110465200&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Tian H, Faje AT, Lee SL, Jorgensen TJ (2002). "Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways". Neoplasia. 4 (2): 171–80. doi:10.1038/sj.neo.7900219. PMC 1550321. PMID 11896572.171-80&rft.date=2002&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550321#id-name=PMC&rft_id=info:pmid/11896572&rft_id=info:doi/10.1038/sj.neo.7900219&rft.aulast=Tian&rft.aufirst=H&rft.au=Faje,+AT&rft.au=Lee,+SL&rft.au=Jorgensen,+TJ&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550321&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Ku NO, Michie S, Resurreccion EZ, Broome RL, Omary MB (April 2002). "Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression". Proceedings of the National Academy of Sciences of the United States of America. 99 (7): 4373–8. Bibcode:2002PNAS...99.4373K. doi:10.1073/pnas.072624299. PMC 123655. PMID 11917136.4373-8&rft.date=2002-04&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC123655#id-name=PMC&rft_id=info:pmid/11917136&rft_id=info:doi/10.1073/pnas.072624299&rft_id=info:bibcode/2002PNAS...99.4373K&rft.aulast=Ku&rft.aufirst=NO&rft.au=Michie,+S&rft.au=Resurreccion,+EZ&rft.au=Broome,+RL&rft.au=Omary,+MB&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC123655&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Urano T, Saito T, Tsukui T, Fujita M, Hosoi T, Muramatsu M, Ouchi Y, Inoue S (June 2002). "Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth". Nature. 417 (6891): 871–5. Bibcode:2002Natur.417..871U. doi:10.1038/nature00826. PMID 12075357. S2CID 4348545.871-5&rft.date=2002-06&rft_id=info:doi/10.1038/nature00826&rft_id=https://api.semanticscholar.org/CorpusID:4348545#id-name=S2CID&rft_id=info:pmid/12075357&rft_id=info:bibcode/2002Natur.417..871U&rft.aulast=Urano&rft.aufirst=T&rft.au=Saito,+T&rft.au=Tsukui,+T&rft.au=Fujita,+M&rft.au=Hosoi,+T&rft.au=Muramatsu,+M&rft.au=Ouchi,+Y&rft.au=Inoue,+S&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Liu MY, Cai S, Espejo A, Bedford MT, Walker CL (November 2002). "14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s)". Cancer Research. 62 (22): 6475–80. PMID 12438239.6475-80&rft.date=2002-11&rft_id=info:pmid/12438239&rft.aulast=Liu&rft.aufirst=MY&rft.au=Cai,+S&rft.au=Espejo,+A&rft.au=Bedford,+MT&rft.au=Walker,+CL&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Bhatia K, Siraj AK, Hussain A, Bu R, Gutiérrez MI (February 2003). "The tumor suppressor gene 14-3-3 sigma is commonly methylated in normal and malignant lymphoid cells". Cancer Epidemiology, Biomarkers & Prevention. 12 (2): 165–9. PMID 12582028.165-9&rft.date=2003-02&rft_id=info:pmid/12582028&rft.aulast=Bhatia&rft.aufirst=K&rft.au=Siraj,+AK&rft.au=Hussain,+A&rft.au=Bu,+R&rft.au=Gutiérrez,+MI&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Kino T, Souvatzoglou E, De Martino MU, Tsopanomihalu M, Wan Y, Chrousos GP (July 2003). "Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway". The Journal of Biological Chemistry. 278 (28): 25651–6. doi:10.1074/jbc.M302818200. PMID 12730237.25651-6&rft.date=2003-07&rft_id=info:doi/10.1074/jbc.M302818200&rft_id=info:pmid/12730237&rft.aulast=Kino&rft.aufirst=T&rft.au=Souvatzoglou,+E&rft.au=De+Martino,+MU&rft.au=Tsopanomihalu,+M&rft.au=Wan,+Y&rft.au=Chrousos,+GP&rft_id=https://doi.org/10.1074%2Fjbc.M302818200&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Nakajima T, Shimooka H, Weixa P, Segawa A, Motegi A, Jian Z, Masuda N, Ide M, Sano T, Oyama T, Tsukagoshi H, Hamanaka K, Maeda M (June 2003). "Immunohistochemical demonstration of 14-3-3 sigma protein in normal human tissues and lung cancers, and the preponderance of its strong expression in epithelial cells of squamous cell lineage". Pathology International. 53 (6): 353–60. doi:10.1046/j.1440-1827.2003.01481.x. PMID 12787309. S2CID 24822056.353-60&rft.date=2003-06&rft_id=https://api.semanticscholar.org/CorpusID:24822056#id-name=S2CID&rft_id=info:pmid/12787309&rft_id=info:doi/10.1046/j.1440-1827.2003.01481.x&rft.aulast=Nakajima&rft.aufirst=T&rft.au=Shimooka,+H&rft.au=Weixa,+P&rft.au=Segawa,+A&rft.au=Motegi,+A&rft.au=Jian,+Z&rft.au=Masuda,+N&rft.au=Ide,+M&rft.au=Sano,+T&rft.au=Oyama,+T&rft.au=Tsukagoshi,+H&rft.au=Hamanaka,+K&rft.au=Maeda,+M&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">
  • Rishi AK, Zhang L, Boyanapalli M, Wali A, Mohammad RM, Yu Y, Fontana JA, Hatfield JS, Dawson MI, Majumdar AP, Reichert U (August 2003). "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437". The Journal of Biological Chemistry. 278 (35): 33422–35. doi:10.1074/jbc.M303173200. PMID 12816952.33422-35&rft.date=2003-08&rft_id=info:doi/10.1074/jbc.M303173200&rft_id=info:pmid/12816952&rft.aulast=Rishi&rft.aufirst=AK&rft.au=Zhang,+L&rft.au=Boyanapalli,+M&rft.au=Wali,+A&rft.au=Mohammad,+RM&rft.au=Yu,+Y&rft.au=Fontana,+JA&rft.au=Hatfield,+JS&rft.au=Dawson,+MI&rft.au=Majumdar,+AP&rft.au=Reichert,+U&rft_id=https://doi.org/10.1074%2Fjbc.M303173200&rfr_id=info:sid/en.wikipedia.org:Stratifin" class="Z3988">


 

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