Wikipedia

Split-brain

This article is about the human brain condition. For the phenomenon in computing, see Split-brain (computing).

Split-brain or callosal syndrome is a type of disconnection syndrome when the corpus callosum connecting the two hemispheres of the brain is severed to some degree. It is an association of symptoms produced by disruption of, or interference with, the connection between the hemispheres of the brain. The surgical operation to produce this condition (corpus callosotomy) involves transection of the corpus callosum, and is usually a last resort to treat refractory epilepsy. Initially, partial callosotomies are performed; if this operation does not succeed, a complete callosotomy is performed to mitigate the risk of accidental physical injury by reducing the severity and violence of epileptic seizures. Before using callosotomies, epilepsy is instead treated through pharmaceutical means. After surgery, neuropsychological assessments are often performed.

After the right and left brain are separated, each hemisphere will have its own separate perception, concepts, and impulses to act. Having two "brains" in one body can create some interesting dilemmas. There was a case in which, when one split-brain patient would dress himself, sometimes he pulled his pants up with one hand (the side of his brain that wanted to get dressed) and down with the other (the side that did not). He was also reported to have grabbed his wife with his left hand and shook her violently, at which point his right hand came to her aid and grabbed the aggressive left hand (a phenomenon sometimes occurring, known as alien hand syndrome). However, such conflicts are very rare. If a conflict arises, one hemisphere usually overrides the other.[1]

When split-brain patients are shown an image only in the left half of each eye's visual field, they cannot verbally name what they have seen. This is because the brain's experiences of the senses is contralateral. Communication between the two hemispheres is inhibited, so the patient cannot say out loud the name of that which the right side of the brain is seeing. A similar effect occurs if a split-brain patient touches an object with only the left hand while receiving no visual cues in the right visual field; the patient will be unable to name the object, as each cerebral hemisphere of the primary somatosensory cortex only contains a tactile representation of the opposite side of the body. If the speech-control center is on the right side of the brain, the same effect can be achieved by presenting the image or object to only the right visual field or hand.[2]

Different sides of the brain specialize in different functions or processes.

The same effect occurs for visual pairs and reasoning. For example, a patient with split brain is shown a picture of a chicken foot and a snowy field in separate visual fields and asked to choose from a list of words the best association with the pictures. The patient would choose a chicken to associate with the chicken foot and a shovel to associate with the snow; however, when asked to reason why the patient chose the shovel, the response would relate to the chicken (e.g. "the shovel is for cleaning out the chicken coop").[3]

History

edit

Early anatomists, such as Galen (129 – c. 216 CE) and Vesalius (1514–1564 CE), identified the corpus callosum. They generally described its function as a structure holding together the two halves of the brain.[4] In 1784, Félix Vicq-d'Azyr described the corpus callosum as allowing communication between the two halves of the brain. He proposed that eliminating the corpus callosum would divide the brain into two independent parts.[4] In 1892, Joseph Jules Dejerine reported symptoms in a person who had destruction of part of the corpus callosum (along with damage to the visual cortex: inability to read while retaining the ability to write, now referred to as pure alexia or as Dejerine syndrome.[4] In 1908, Hugo Liepmann observed left-sided apraxia (a motor disorder of motor planning to perform tasks or movements) and agraphia (loss of the ability to communicate through writing) following a lesion in the corpus callosum.[4]

According to Vaddiparti et al. (2021), the first surgical cuts to the corpus callosum, partial corpus callosotomy, were made by neurosurgeon Walter Dandy in order to access and to remove tumors in the pineal gland.[4] In 1936, Dandy described three cases in which he cut the corpus callosum from its posterior (towards the back of the head) across about two thirds of its width. He described these cuts as "bloodless" and that "no symptoms follow[ed] [the] ... division" of the corpus callosum. He concluded that his operations "dispose ... of the extravagant claims to function of the corpus callosum".[5]: 40 

Prior to the 1960s, research on people with certain brain injuries led to the notion that there is a "language center" only in the left hemisphere of the brain. For example, people with lesions in two specific areas of the left hemisphere lost their ability to talk, to read, and to understand speech. Roger Sperry and his colleagues pioneered research showing that creating another lesion (done to relieve otherwise untreatable epilepsy), in the connections between the left and right hemispheres, revealed that the right hemisphere can allow people to read, to understand speech, and to say some simple words. Research over the next twenty years showed that the disconnected right hemisphere is superior to the disconnected left hemisphere in allowing people to understand spatial information (such as maps), music, and emotions, whereas the disconnected left hemisphere is superior in allowing analytical thinking, talking, reading, and understanding speech. This research led to a Nobel Prize in Physiology or Medicine for Sperry in 1981.[6]

Sperry's initial colleagues included his Caltech PhD students, Michael Gazzaniga and Jerre Levy. Even though Sperry is considered the founder of split-brain research, Gazzaniga's clear summaries of their collaborative work are consistently cited in psychology texts. In Sperry and Gazzaniga's "The Split Brain in Man" experiment published in Scientific American in 1967 they attempted to explore the extent to which two halves of the human brain were able to function independently and whether or not they had separate and unique abilities. They wanted to examine how perceptual and intellectual skills were affected in someone with a split brain. At Caltech, Gazzaniga worked with Sperry on the effects of split-brain surgery on perception, vision and other brain functions. The surgery, which was a treatment for severe epilepsy, involved severing the corpus callosum, which carries signals between the left-brain hemisphere, the seat of speech and analytical capacity, and the right-brain hemisphere, which helps recognize visual patterns. At the time this article was written, only ten patients had undergone the surgery to sever their corpus callosum (corpus callosotomy). Four of these patients had consented to participate in Sperry and Gazzaniga's research. After the corpus callosum severing, all four participants' personality, intelligence, and emotions appeared to be unaffected. However, the testing done by Sperry and Gazzaniga showed the subjects demonstrated unusual mental abilities. The researchers created different types of tests to analyze the range of cognitive capabilities of the split-brain subjects. These included tests of their visual stimulation abilities, a tactile stimulation situation, and a test that involved both visual and tactile information.

Visual test

edit

The first test started with a board that had a horizontal row of lights. The subject was told to sit in front of the board and stare at a point in the middle of the lights, then the bulbs would flash across both the right and left visual fields. When the patients were asked to describe afterward what they saw, they said that only the lights on the right side of the board had lit up. Next, when Sperry and Gazzaniga flashed the lights on the right side of the board on the subjects left side of their visual field, they claimed not to have seen any lights at all. When the experimenters conducted the test again, they asked the subjects to point to the lights that lit up. Although subjects had only reported seeing the lights flash on the right, they actually pointed to all the lights in both visual fields. This showed that both brain hemispheres had seen the lights and were equally competent in visual perception. The subjects did not say they saw the lights when they flashed in the left visual field even though they did see them because the center for speech is located in the brain's left hemisphere. This test supports the idea that in order to say one has seen something, the region of the brain associated with speech must be able to communicate with areas of the brain that process the visual information.[citation needed]

Tactile test

edit

In a second experiment, Sperry and Gazzaniga placed a small object in the subject's right or left hand, without the subject being able to see (or hear) it. When the object was placed in the right hand, the isolated left hemisphere perceived the object and could easily describe and name it. However, when the object was placed in the left hand, the isolated right hemisphere could not name or describe the object. Questioning this result, the researchers found that the subjects could later match it from several similar objects; tactile sensations limited to the right hemisphere were accurately perceived but could not be verbalized. This further demonstrated the apparent location (or lateralization) of language functions in the left hemisphere.[citation needed]

Combination of both tests

edit

In the last test the experimenters combined both the tactile and visual test. They presented subjects with a picture of an object to only their right hemisphere, and subjects were unable to name it or describe it. There were no verbal responses to the picture at all. If the subject however was able to reach under the screen with their left hand to touch various objects, they were able to pick the one that had been shown in the picture. The subjects were also reported to be able to pick out objects that were related to the picture presented, if that object was not under the screen.[7]

Sperry and Gazzaniga went on to conduct other tests to shed light on the language processing abilities of the right hemisphere as well as auditory and emotional reactions as well. The significance of the findings of these tests by Sperry and Gazzaniga was extremely telling and important to the psychology world. Their findings showed that the two halves of the brain have numerous functions and specialized skills. They concluded that each hemisphere really has its own functions. One's left hemisphere of the brain is thought to be better at writing, speaking, mathematical calculation, reading, and is the primary area for language. The right hemisphere is seen to possess capabilities for problem solving, recognizing faces, symbolic reasoning, art, and spatial relationships.[citation needed]

Roger Sperry continued this line of research up until his death in 1994. Michael Gazzaniga continues to research the split brain. Their findings have been rarely critiqued and disputed; however, a popular belief that some people are more "right-brained" or "left-brained" has developed. In the mid-1980s Jarre Levy, a psychobiologist at the University of Chicago, was at the forefront of scientists who wanted to dispel the notion we have two functioning brains. She believes that because each hemisphere has separate functions that they must integrate their abilities instead of separating them. Levy also claims that no human activity uses only one side of the brain. In 1998 a French study by Hommet and Billiard was published that questioned Sperry and Gazzaniga's study that severing the corpus callosum actually divides the hemispheres of the brain. They found that children born without a corpus callosum demonstrated that information was being transmitted between hemispheres, and concluded that subcortical connections must be present in these children with this rare brain malformation. They are unclear about whether these connections are present in split-brain patients though. Another study by Parsons, Gabrieli, Phelps, and Gazzaniga in 1998 demonstrated that split-brain patients may commonly perceive the world differently from the rest of us. Their study suggested that communication between brain hemispheres is necessary for imaging or simulating in one's mind the movements of others. Morin's research on inner speech in 2001 suggested an alternative for interpretation of commissurotomy according to which split-brain patients exhibit two uneven streams of self-awareness: a "complete" one in the left hemisphere and a "primitive" one in the right hemisphere.[8]

Hemispheric specialization

edit

The two hemispheres of the cerebral cortex are linked by the corpus callosum, through which they communicate and coordinate actions and decisions. Communication and coordination between the two hemispheres is essential because each hemisphere has some separate functions.[9] The right hemisphere of the cortex excels at nonverbal and spatial tasks, whereas the left hemisphere is more dominant in verbal tasks, such as speaking and writing. The right hemisphere controls the primary sensory functions of the left side of the body. In a cognitive sense the right hemisphere is responsible for recognizing objects and timing, and in an emotional sense it is responsible for empathy, humor and depression. On the other hand, the left hemisphere controls the primary sensory functions of the right side of the body and is responsible for scientific and math skills, and logic.[10] The extent of specialized brain function by an area remains under investigation. It is claimed that the difference between the two hemispheres is that the left hemisphere is "analytic" or "logical" while the right hemisphere is "holistic" or "intuitive".[11] Many simple tasks, especially comprehension of inputs, require functions that are specific to both the right and left hemispheres and together form a one-direction systematized way of creating an output[clarification needed] through the communication and coordination that occurs between hemispheres.[12]

Role of the corpus callosum

edit
 
The corpus callosum, highlighted in red, is the main neural pathway between the two hemispheres.

The corpus callosum is a structure in the brain along the longitudinal fissure that facilitates much of the communication between the two hemispheres. This structure is composed of white matter: millions of axons that have their dendrites and terminal boutons projecting in both the right and left hemisphere. However, there is evidence that the corpus callosum may also have some inhibitory functions.[13] Post-mortem research on human and monkey brains shows that the corpus callosum is functionally organized.[14] This organization results in modality-specific regions of the corpus callosum that are responsible for the transfer of different types of information. Research has revealed that the anterior midbody transfers motor information, the posterior midbody transfers somatosensory information, the isthmus transfers auditory information, and the splenium transfers visual information.[15] Although much of the inter-hemispheric transfer occurs at the corpus callosum, there are trace amounts of transfer via commissural pathways, such as the anterior commissure, posterior commissure, habenular commissure, and the hippocampal commissure.[16]

Studies of the effects on the visual pathway on split-brained patients has revealed that there is a redundancy gain (the ability of target detection to benefit from multiple copies of the target) in simple reaction time. In a simple response to visual stimuli, split-brained patients experience a faster reaction time to bilateral stimuli than predicted by model.[17] A model proposed by Iacoboni et al.[18] suggests split-brained patients experience asynchronous activity that causes a stronger signal, and thus a decreased reaction time. Iacoboni also suggests there exists dual attention in split-brained patients, which implies that each cerebral hemisphere has its own attentional system.[19] An alternative approach taken by Reuter-Lorenz et al.[20] suggests that enhanced redundancy gain in the split brain is primarily due to a slowing of responses to unilateral stimuli, rather than a speeding of responses to bilateral ones.

The simple reaction time in split-brained patients, even with enhanced redundancy gain, is slower than the reaction time of normal adults.[citation needed]

Functional plasticity

edit

Following a stroke or other injury to the brain, functional deficiencies are common. The deficits are expected to be in areas related to the part of the brain that has been damaged; if a stroke has occurred in the motor cortex, deficits may include paralysis, abnormal posture, or abnormal movement synergies.[21] Significant recovery occurs during the first several weeks after the injury. However, recovery is generally thought not to continue past six months. If a specific region of the brain is injured or destroyed, its functions can sometimes be transferred and taken over by a neighboring region. There is little functional plasticity observed in partial and complete callosotomies; however, much more plasticity can be seen in infant patients receiving a hemispherectomy, which suggests that the opposite hemisphere can adapt some functions typically performed by its opposite pair. A study performed by Anderson et al. (2005) proved a correlation between the severity of the injury, the age of the individual, and their cognitive performance. It was evident that there was more neuroplasticity in older children—even if their injury was extremely severe—than in infants who suffered moderate brain injury.[22] In some incidents of any moderate to severe brain injury, it mostly causes developmental impairments and in some of the most severe injuries it can cause a profound impact on their development that can lead to long-term cognitive effects. In the aging brain, it is extremely uncommon for neuroplasticity to occur; "olfactory bulb and hippocampus are two regions of the mammalian brain in which mutations preventing adult neurogenesis were never beneficial, or simply never occurred".[22]

 
The picture is about a normal brain and a person with a split brain

Corpus callosotomy

edit

Corpus callosotomy is a surgical procedure that sections the corpus callosum, resulting in either the partial or complete disconnection between the two hemispheres. It is typically used as a last-resort measure in treatment of intractable epilepsy. The modern procedure typically involves only the anterior third of the corpus callosum; however, if the epileptic seizures continue, the following third is lesioned prior to the remaining third if the seizures persist. This results in a complete callosotomy in which most of the information transfer between hemispheres is lost.[23]

Due to the functional mapping of the corpus callosum, a partial callosotomy has fewer detrimental effects because it leaves parts of the corpus callosum intact. There is little functional plasticity observed in partial and complete callosotomies on adults; the most neuroplasticity is seen in young children but not in infants.[24]

It is known that when the corpus callosum is severed during an experimental procedure, the experimenter can ask each side of the brain the same question and receive two different answers. When the experimenter asks the right visual field / left hemisphere what they see the participant will respond verbally, whereas if the experimenter asks the left visual field / right hemisphere what they see the participant will not be able to respond verbally but will pick up the appropriate object with their left hand.[25]

Memory

edit

It is known that the right and the left hemisphere have different functions when it comes to memory.[26] The right hemisphere is better at recognizing objects and faces, recalling knowledge that the individual has already learned, or recalling images already seen. The left hemisphere is better at mental manipulation, language production, and semantic priming but was more susceptible to memory confusion than the right hemisphere.[27] The main issue for individuals that have undergone a callosotomy is that because the function of memory is split into two major systems, the individual is more likely to become confused between knowledge they already know and information that they have only inferred.[27]

In tests, memory in either hemisphere of split-brained patients is generally lower than normal, though better than in patients with amnesia, suggesting that the forebrain commissures are important for the formation of some kinds of memory. This suggests that posterior callosal sections that include the hippocampal commissures cause a mild memory deficit (in standardized free-field testing) involving recognition.[28] This makes first-person accounts hard to consider and to assess as scientists don't know if the consciousness was split as well.[29]

Control

edit

In general, split-brained patients behave in a coordinated, purposeful, and consistent manner, despite the independent, parallel, usually different, and occasionally conflicting processing of the same information from the environment by the two disconnected hemispheres. When two hemispheres receive competing stimuli at the same time, the response mode tends to determine which hemisphere controls behavior.[30][verification needed]

Often, split-brained patients are indistinguishable from normal adults. This is due to the compensatory phenomena; split-brained patients progressively acquire a variety of strategies to get around their interhemispheric transfer deficits.[31][self-published source?] One issue that can happen with their body control is that one side of the body is doing the opposite of the other side, called the intermanual effect.[citation needed]

Attention

edit

Experiments on covert orienting of spatial attention using the Posner paradigm confirm the existence of two different attentional systems in the two hemispheres.[32] The right hemisphere was found superior to the left hemisphere on modified versions of spatial relations tests and in locations testing, whereas the left hemisphere was more object based.[33] The components of mental imagery are differentially specialized: the right hemisphere was found superior for mental rotation,[34] the left hemisphere superior for image generation.[35] It was also found that the right hemisphere paid more attention to landmarks and scenes whereas the left hemisphere paid more attention to exemplars of categories.[36]

Surgery procedure

edit

The surgical operation to produce this condition (corpucallosotomy) involves transection of the corpus callosum, and is usually a last resort to treat refractory epilepsy. To lower the degree and ferocity of epileptic convulsions, partial callosotomies are first done; if these are unsuccessful, a callosotomy is next carried out to reduce the risk of unintentional bodily harm. Epilepsy is first managed with medications rather than callosotomies. Neuropsychological evaluations following surgery are frequently carried out.

Case studies of split-brain patients

edit

Patient WJ

edit

Patient WJ was the first patient to undergo a full corpus callosotomy in 1962, after experiencing fifteen years of convulsions resulting from grand mal seizures. He was a World War II paratrooper who was injured at 30 years old during a bombing raid jump over the Netherlands, and again in a prison camp following his first injury. After returning home, he began to suffer from blackouts in which he would not remember what he was doing or where, and how or when he got there. At age 37, he suffered his first generalized convulsion. One of his worst episodes occurred in 1953, when he suffered a series of convulsions lasting for many days. During these convulsions, his left side would go numb and he would recover quickly, but after the series of convulsions, he never regained complete feeling on his left side.[37]

Before his surgery, both hemispheres functioned and interacted normally, his sensory and motor functions were normal aside from slight hypoesthesia, and he could correctly identify and understand visual stimuli presented to both sides of his visual field. During his surgery in 1962, his surgeons determined that no massa intermedia had developed, and he had undergone atrophy in the part of the right frontal lobe exposed during the procedure. His operation was a success, in that it led to decreases in the frequency and intensity of his seizures.[37]

Patient JW

edit

Funnell et al. (2007) tested patient JW some time before June 2006.[38] They described JW as

a right-handed male who was 47 years old at the time of testing. He successfully completed high school and has no reported learning disabilities. He had his first seizure at the age of 16 and the age of 25, he underwent a two-stage resection of the corpus callosum for relief of intractable epilepsy. Complete sectioning of the corpus callosum has been confirmed by MRI.[39] Post-surgical MRI also revealed no evidence of other neurological damage.[verification needed]

Funnell et al.'s (2007) experiments were to determine each of JW's hemisphere's ability to perform simple addition, subtraction, multiplication and division. For example, in one experiment, on each trial, they presented an arithmetic problem in the center of the screen for one second, followed by a central crosshair JW was to look at. After one more second, Funnell et al. presented a number to one or the other hemisphere / visual field for 150 ms—too fast for JW to move his eyes. Randomly in half the trials, the number was the correct answer; in the other half of the trials it was the incorrect answer. With the hand on the same side as the number, JW pressed one key if the number was correct and another key if the number was incorrect.[38]

Funnell et al.'s results were that performance of the left hemisphere was highly accurate (around 95%)—much better than performance of the right hemisphere, which was at chance for subtraction, multiplication, and division. Nevertheless the right hemisphere showed better-than-chance performance for addition (around 58%).[40]

Turk et al. (2002) tested hemispheric differences in JW's recognition of himself and of familiar faces.[41] They used faces that were composites of JW's face and Dr. Michael Gazzaniga's face. Composites ranged from 100% JW, through 50% JW and 50% Gazzaniga, to 100% Gazzaniga. JW pressed keys to say whether a presented face looked like him or Gazzaniga. Turk et al. concluded there are cortical networks in the left hemisphere that play an important role in self-recognition.[citation needed]

Patient VP

edit

Patient VP[42] is a woman who underwent a two-stage callosotomy in 1979 at the age of 27. Although the callosotomy was reported to be complete, a follow-up MRI in 1984 revealed spared fibers in the rostrum and splenium. The spared rostral fibers constituted approximately 1.8% of the total cross-sectional area of the corpus callosum and the spared splenial fibers constituted approximately 1% of the area.[39] VP's postsurgery intelligence and memory quotients were within normal limits.[43]

One of the experiments involving VP attempted to investigate systematically the types of visual information that could be transferred via VP's spared splenial fibers. The first experiment was designed to assess VP's ability to make between-field perceptual judgments about simultaneously presented pairs of stimuli. The stimuli were presented in varying positions with respect to the horizontal and vertical midline with VP's vision fixated on a central crosshair. The judgments were based on differences in color, shape or size. The testing procedure was the same for all three types of stimuli; after presentation of each pair, VP verbally responded "yes" if the two items in the pair were identical and "no" if they were not. The results show that there was no perceptual transfer for color, size or shape with binomial tests showing that VP's accuracy was not greater than chance.[citation needed]

A second experiment involving VP attempted to investigate what aspects of words transferred between the two hemispheres. The set up was similar to the previous experiment, with VP's vision fixated on a central crosshair. A word pair was presented with one word on each side of the crosshair for 150 ms. The words presented were in one of four categories: words that looked and sounded like rhymes (e.g. tire and fire), words that looked as if they should rhyme but did not (e.g. cough and dough), words that did not look as if they should rhyme but did (e.g. bake and ache), and words that neither looked nor sounded like rhymes (e.g. keys and fort). After presentation of each word pair, VP responded "yes" if the two words rhymed and "no" if they did not. VP's performance was above chance and she was able to distinguish among the different conditions. When the word pairs did not sound like rhymes, VP was able to say accurately that the words did not rhyme, regardless of whether or not they looked as if they should rhyme. When the words did rhyme, VP was more likely to say they rhymed, particularly if the words also looked as if they should rhyme.[citation needed]

Although VP showed no evidence for transfer of color, shape or size, there was evidence for transfer of word information.[44] This is consistent with the speculation that the transfer of word information involves fibers in the ventroposterior region of the splenium—the same region in which VP had callosal sparing. VP is able to integrate words presented to both visual fields, creating a concept that is not suggested by either word. For example, she combines "head" and "stone" to form the integrated concept of a tombstone.[citation needed]

Kim Peek

edit

Kim Peek[45] was arguably the most well-known savant. He was born on November 11, 1951, with an enlarged head, sac-like protrusions of the brain and the membranes that cover it through openings in the skull, a malformed cerebellum, and without a corpus callosum, an anterior commissure, or a posterior commissure. He was able to memorize over 9,000 books, and information from approximately 15 subject areas. These include: world/American history, sports, movies, geography, actors and actresses, the Bible, church history, literature, classical music, area codes/zip codes of the United States, television stations serving these areas, and step-by-step directions within any major U.S. city. Despite these abilities, he had an IQ of 87, was diagnosed as autistic, was unable to button his shirt, and had difficulties performing everyday tasks. The missing structures of his brain have yet to be linked to his increased abilities, but they can be linked to his ability to read pages of a book in 8–10 seconds. He was able to view the left page of a book with his left visual field and the right page of a book with his right visual fields so he could read both pages simultaneously.[46] He also had developed language areas in both hemispheres, something very uncommon in split-brain patients. Language[46] is processed in areas of the left temporal lobe, and involves a contralateral transfer of information before the brain can process what is being read. In Peek's case, there was no transfer ability—this is what led to his development of language centers in each hemisphere.

Although Peek did not undergo corpus callosotomy, he is considered a natural split-brain patient and is critical to understanding the importance of the corpus callosum. Kim Peek died in 2009.[46]

See also

edit

References

edit
  1. ^ Coon, Dennis; Mitterer, John O. (January 1, 2012). Introduction to Psychology Gateways to Mind and Behavior. Cengage Learning. p. 65. ISBN 9781111833633.
  2. ^ De Haan, E. H.; Corballis, P. M.; Hillyard, S. A.; Marzi, C. A.; Seth, A.; Lamme, V. A.; Volz, L.; Fabri, M.; Schechter, E.; Bayne, T.; Corballis, M.; Pinto, Y. (2020). "Split-Brain: What We Know Now and Why This is Important for Understanding Consciousness". Neuropsychology Review. 30 (2): 224–233. doi:10.1007/s11065-020-09439-3. PMC 7305066. PMID 32399946.224-233&rft.date=2020&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305066#id-name=PMC&rft_id=info:pmid/32399946&rft_id=info:doi/10.1007/s11065-020-09439-3&rft.aulast=De Haan&rft.aufirst=E. H.&rft.au=Corballis, P. M.&rft.au=Hillyard, S. A.&rft.au=Marzi, C. A.&rft.au=Seth, A.&rft.au=Lamme, V. A.&rft.au=Volz, L.&rft.au=Fabri, M.&rft.au=Schechter, E.&rft.au=Bayne, T.&rft.au=Corballis, M.&rft.au=Pinto, Y.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305066&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  3. ^ Gazzaniga, Michael S. (July 1, 2000). "Cerebral specialization and interhemispheric communication: Does the corpus callosum enable the human condition?". Brain. 123 (7): 1293–1326. doi:10.1093/brain/123.7.1293. PMID 10869045.1293-1326&rft.date=2000-07-01&rft_id=info:doi/10.1093/brain/123.7.1293&rft_id=info:pmid/10869045&rft.aulast=Gazzaniga&rft.aufirst=Michael S.&rft_id=https://doi.org/10.1093%2Fbrain%2F123.7.1293&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  4. ^ a b c d e Vaddiparti, A., Huang, R., Blihar, D., DuPlessis, M., Montalbano, M. J., Tubbs, R. S., & Loukas, M. (2021). "The evolution of corpus callosotomy for epilepsy management". World Neurosurgery. 145: 455–461. doi:10.1016/j.wneu.2020.08.178. PMID 32889189. S2CID 221502280. Retrieved November 2, 2022.455-461&rft.date=2021&rft_id=https://api.semanticscholar.org/CorpusID:221502280#id-name=S2CID&rft_id=info:pmid/32889189&rft_id=info:doi/10.1016/j.wneu.2020.08.178&rft.au=Vaddiparti, A., Huang, R., Blihar, D., DuPlessis, M., Montalbano, M. J., Tubbs, R. S., & Loukas, M.&rft_id=https://doi.org/10.1016/j.wneu.2020.08.178&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. ^ Dandy, Walter E. (1936). "Operative experience in cases of pineal tumor". Archives of Surgery. 33 (1): 19–46. doi:10.1001/archsurg.1936.01190010022002. Retrieved November 3, 2022.19-46&rft.date=1936&rft_id=info:doi/10.1001/archsurg.1936.01190010022002&rft.aulast=Dandy&rft.aufirst=Walter E.&rft_id=https://doi.org/10.1001/archsurg.1936.01190010022002&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  6. ^ "The Split Brain Experiments". Nobel Media. Retrieved April 27, 2014.
  7. ^ Gazzaniga, Michael (1967). "The Split Brain in Man". Scientific American. 217 (2): 24–29. Bibcode:1967SciAm.217b..24G. doi:10.1038/scientificamerican0867-24.24-29&rft.date=1967&rft_id=info:doi/10.1038/scientificamerican0867-24&rft_id=info:bibcode/1967SciAm.217b..24G&rft.aulast=Gazzaniga&rft.aufirst=Michael&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  8. ^ Hock, Roger R. (2005). Forty Studies that Changed Psychology: Explorations into the History of Research. Upper Saddle River. ISBN 978-0-13-114729-4.
  9. ^ Adams, Juliet. "The Neuroscience of Mindfulness". Mindfulnet. Archived from the original on February 10, 2011. Retrieved April 28, 2014.
  10. ^ Witelson, Sandra F.; Wazir Pallie (1973). "Left Hemisphere Specialization for Language in the Newborn". Neuroanatomical Evidence of Asymmetry. 96 (3): 641–646. doi:10.1093/brain/96.3.641. PMID 4795531.641-646&rft.date=1973&rft_id=info:doi/10.1093/brain/96.3.641&rft_id=info:pmid/4795531&rft.aulast=Witelson&rft.aufirst=Sandra F.&rft.au=Wazir Pallie&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  11. ^ "Archived copy" (PDF). Archived from the original (PDF) on July 24, 2015. Retrieved March 15, 2012.{{cite web}}: CS1 maint: archived copy as title (link)
  12. ^ Borod, Joan; Andelman, Fani; Obler, Loraine K.; Tweedy, James; Wilkowitz, Joan (1992). "Right Hemisphere Specialization for the Identification of Emotional Words and Sentences". Neuropsychologia. 30 (9): 827–844. doi:10.1016/0028-3932(92)90086-2. PMID 1407497. S2CID 31912202.827-844&rft.date=1992&rft_id=https://api.semanticscholar.org/CorpusID:31912202#id-name=S2CID&rft_id=info:pmid/1407497&rft_id=info:doi/10.1016/0028-3932(92)90086-2&rft.aulast=Borod&rft.aufirst=Joan&rft.au=Andelman, Fani&rft.au=Obler, Loraine K.&rft.au=Tweedy, James&rft.au=Wilkowitz, Joan&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  13. ^ O'Shea, R. P. (2003). "Binocular rivalry in split-brain observers". Journal of Vision. 3 (10): 610–615. doi:10.1167/3.10.3. PMID 14640884.610-615&rft.date=2003&rft_id=info:doi/10.1167/3.10.3&rft_id=info:pmid/14640884&rft.aulast=O'Shea&rft.aufirst=R. P.&rft_id=https://doi.org/10.1167%2F3.10.3&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  14. ^ Mooshagian, Eric (2008). "Anatomy of the Corpus Callosum reveals its Function". Journal of Neuroscience. 28 (7): 1535–1536. doi:10.1523/JNEUROSCI.5426-07.2008. PMC 6671538. PMID 18272674.1535-1536&rft.date=2008&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671538#id-name=PMC&rft_id=info:pmid/18272674&rft_id=info:doi/10.1523/JNEUROSCI.5426-07.2008&rft.aulast=Mooshagian&rft.aufirst=Eric&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671538&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  15. ^ Risse GL, Gates J, Lund G, Maxwell R, Rubens A (1989). "Inter-hemispheric transfer in patients with incomplete section of the corpus callosum: anatomic verification with magnetic resonance imaging". Archives of Neurology. 46 (4): 437–443. doi:10.1001/archneur.1989.00520400097026. PMID 2705905.437-443&rft.date=1989&rft_id=info:doi/10.1001/archneur.1989.00520400097026&rft_id=info:pmid/2705905&rft.aulast=Risse&rft.aufirst=GL&rft.au=Gates, J&rft.au=Lund, G&rft.au=Maxwell, R&rft.au=Rubens, A&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  16. ^ "Commissural pathways". Kenhub. Retrieved November 16, 2023.
  17. ^ Corballis, M. C.; Corballis, P. M.; Fabri, M. (2003). "Redundancy gain in simple reaction time following partial and complete callosotomy". Neuropsychologia. 42 (1): 71–81. CiteSeerX 10.1.1.503.8952. doi:10.1016/s0028-3932(03)00152-0. PMID 14615077. S2CID 45852555.71-81&rft.date=2003&rft_id=https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.503.8952#id-name=CiteSeerX&rft_id=https://api.semanticscholar.org/CorpusID:45852555#id-name=S2CID&rft_id=info:pmid/14615077&rft_id=info:doi/10.1016/s0028-3932(03)00152-0&rft.aulast=Corballis&rft.aufirst=M. C.&rft.au=Corballis, P. M.&rft.au=Fabri, M.&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  18. ^ Iacoboni, M.; Fried, I.; Zaidel, E. (1994). "Callosal transmission time before and after partial commissurotomy". NeuroReport. 5 (18): 2521–2524. doi:10.1097/00001756-199412000-00029. PMID 7696863.2521-2524&rft.date=1994&rft_id=info:doi/10.1097/00001756-199412000-00029&rft_id=info:pmid/7696863&rft.aulast=Iacoboni&rft.aufirst=M.&rft.au=Fried, I.&rft.au=Zaidel, E.&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  19. ^ Arguin, M.; Lassonde, M.; Quattrini, A.; Del Pesce, M.; Foschi, N.; Papo, I. (2000). "Divided visuo-spatial attention systems with total and anterior callosotomy". Neuropsychologia. 38 (3): 283–291. doi:10.1016/s0028-3932(99)00077-9. PMID 10678694. S2CID 23798895.283-291&rft.date=2000&rft_id=https://api.semanticscholar.org/CorpusID:23798895#id-name=S2CID&rft_id=info:pmid/10678694&rft_id=info:doi/10.1016/s0028-3932(99)50077-9&rft.aulast=Arguin&rft.aufirst=M.&rft.au=Lassonde, M.&rft.au=Quattrini, A.&rft.au=Del Pesce, M.&rft.au=Foschi, N.&rft.au=Papo, I.&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  20. ^ Reuter-Lorenz, P. A.; Nozawa, G.; Gazzaniga, M. S.; Hughes, H. C. (1995). "Fate of neglected targets: a chronometric analysis of redundant target effects in the bisected brain". Journal of Experimental Psychology: Human Perception and Performance. 21 (2): 211–230. doi:10.1037/0096-1523.21.2.211. PMID 7714469.211-230&rft.date=1995&rft_id=info:doi/10.1037/0096-1523.21.2.211&rft_id=info:pmid/7714469&rft.aulast=Reuter-Lorenz&rft.aufirst=P. A.&rft.au=Nozawa, G.&rft.au=Gazzaniga, M. S.&rft.au=Hughes, H. C.&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  21. ^ Nudo, R. J.; Plautz, E. J.; Frost, S. B. (2001). "Role of adaptive plasticity in recovery of function after damage to motor cortex. [Review]". Muscle & Nerve. 24 (8): 1000–1019. doi:10.1002/mus.1104. PMID 11439375. S2CID 32457492.1000-1019&rft.date=2001&rft_id=https://api.semanticscholar.org/CorpusID:32457492#id-name=S2CID&rft_id=info:pmid/11439375&rft_id=info:doi/10.1002/mus.1104&rft.aulast=Nudo&rft.aufirst=R. J.&rft.au=Plautz, E. J.&rft.au=Frost, S. B.&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  22. ^ a b Anderson, Vicki; Catroppa, Cathy; Morse, Sue; Haritou, Flora; Rosenfeld, Jeffrey (2005). "Functional Plasticity or Vulnerability after Early Brain Injury". Pediatrics. 11 (6): 1374–1382. doi:10.1542/peds.2004-1728. PMID 16322161. S2CID 25849302.1374-1382&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:25849302#id-name=S2CID&rft_id=info:pmid/16322161&rft_id=info:doi/10.1542/peds.2004-1728&rft.aulast=Anderson&rft.aufirst=Vicki&rft.au=Catroppa, Cathy&rft.au=Morse, Sue&rft.au=Haritou, Flora&rft.au=Rosenfeld, Jeffrey&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  23. ^ "Corpus Callosotomy: How it's Done, Risks & Benefits, Recovery, Outlook". Cleveland Clinic. Retrieved November 16, 2023.
  24. ^ Concha, Luis; Gross, Donald; Wheatley, Matt; Beaulieu, Christian (2006). "Diffusion Tensor Imaging of Time-Dependent Axonal and Myelin Degradation after Corpus Callosotomy in Epilepsy Patients". NeuroImage. 32 (3): 1090–1099. doi:10.1016/j.neuroimage.2006.04.187. PMID 16765064. S2CID 36514894.1090-1099&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:36514894#id-name=S2CID&rft_id=info:pmid/16765064&rft_id=info:doi/10.1016/j.neuroimage.2006.04.187&rft.aulast=Concha&rft.aufirst=Luis&rft.au=Gross, Donald&rft.au=Wheatley, Matt&rft.au=Beaulieu, Christian&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  25. ^ Raven, Peter (2014). Biology. New York: McGraw-Hill. ISBN 9780073383071.
  26. ^ "Anatomy of the Brain". Mayfield Clinic.
  27. ^ a b Metcalfe, Janet; Funnell, Margaret; Gazzanuga, Michael (1995). "Right-Hemisphere Memory Superiority:Studies of Split-brain Patient". Psychological Science. 6 (3): 157–164. doi:10.1111/j.1467-9280.1995.tb00325.x. JSTOR 40063008. S2CID 3187008.157-164&rft.date=1995&rft_id=https://api.semanticscholar.org/CorpusID:3187008#id-name=S2CID&rft_id=https://www.jstor.org/stable/40063008#id-name=JSTOR&rft_id=info:doi/10.1111/j.1467-9280.1995.tb00325.x&rft.aulast=Metcalfe&rft.aufirst=Janet&rft.au=Funnell, Margaret&rft.au=Gazzanuga, Michael&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  28. ^ Tramo MJ, Baynes K, Fendrich R, Mangun GR, Phelps EA, Reuter-Lorenz PA, Gazzaniga MS (1995). "Hemispheric specialization and interhemispheric integration: Insights from experiments with commissurotomy patients". In Reeves AG, Roberts DW (eds.). Epilepsy and the Corpus Callosum. Vol. 2. New York: Plenum. pp. 263–295.263-295&rft.pub=Plenum&rft.date=1995&rft.aulast=Tramo&rft.aufirst=MJ&rft.au=Baynes, K&rft.au=Fendrich, R&rft.au=Mangun, GR&rft.au=Phelps, EA&rft.au=Reuter-Lorenz, PA&rft.au=Gazzaniga, MS&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  29. ^ "APA PsycNet". psycnet.apa.org. Retrieved October 10, 2023.
  30. ^ Levy J, Trevarthen C (1976). "Metacontrol of hemispheric function in human split-brain patients". Journal of Experimental Psychology: Human Perception and Performance. 2 (3): 299–312. doi:10.1037/0096-1523.2.3.299. PMID 993737.299-312&rft.date=1976&rft_id=info:doi/10.1037/0096-1523.2.3.299&rft_id=info:pmid/993737&rft.aulast=Levy&rft.aufirst=J&rft.au=Trevarthen, C&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  31. ^ Manning, Mark L. "Other Multiplicity". Dr. Mark and Rana Manning. Archived from the original on March 1, 2017. Retrieved April 28, 2014.
  32. ^ Zaidel E (1994). "Interhemispheric transfer in the split brain: Long term status following complete cerebral commissurotomy". In Davidson RH, Hugdahl K (eds.). Human Laterality. Cambridge, Massachusetts: MIT Press. pp. 491–532.491-532&rft.pub=MIT Press&rft.date=1994&rft.aulast=Zaidel&rft.aufirst=E.&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  33. ^ Nebes RD (1990). "The commissurotomized brain (Section 7)". In Boiler F, Grafman J (eds.). Handbook of Neuropsychology. Vol. 4. Amsterdam: Elsevier. pp. 3–168.3-168&rft.pub=Elsevier&rft.date=1990&rft.aulast=Nebes&rft.aufirst=RD&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  34. ^ Sergent, Justine; Corballis, Michael C. (1989). "Categorization of disoriented faces in the cerebral hemispheres of normal and commissurotomized subjects". Journal of Experimental Psychology: Human Perception and Performance. 15 (4): 701–710. doi:10.1037/0096-1523.15.4.701. PMID 2531205. S2CID 30870644.701-710&rft.date=1989&rft_id=https://api.semanticscholar.org/CorpusID:30870644#id-name=S2CID&rft_id=info:pmid/2531205&rft_id=info:doi/10.1037/0096-1523.15.4.701&rft.aulast=Sergent&rft.aufirst=Justine&rft.au=Corballis, Michael C.&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  35. ^ Farah, Martha J. (1986). "The laterality of mental image generation: A test with normal subjects". Neuropsychologia. 24 (4): 541–551. doi:10.1016/0028-3932(86)90098-9. PMID 3774139. S2CID 3262591.541-551&rft.date=1986&rft_id=https://api.semanticscholar.org/CorpusID:3262591#id-name=S2CID&rft_id=info:pmid/3774139&rft_id=info:doi/10.1016/0028-3932(86)90098-9&rft.aulast=Farah&rft.aufirst=Martha J.&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  36. ^ Zaidel, Eran. "The Split Brain". Archived from the original on July 29, 2014. Retrieved April 28, 2014.
  37. ^ a b Eldridge, A. D. (n.d.). Discovering the unique individuals behind split-brain patient anonymity. Doctoral dissertation, University of North Carolina at Wilmington, Wilmington, NC. Retrieved from http://people.uncw.edu/puente/405/PDFpapers/Split-brain Patients.pdf Archived 2016-03-04 at the Wayback Machine
  38. ^ a b Funnell M. G.; Colvin M. K.; Gazzaniga M. S. (2007). "The calculating hemispheres: Studies of a split-brain patient". Neuropsychologia. 45 (10): 2378–2386. doi:10.1016/j.neuropsychologia.2007.01.017. PMID 17420034. S2CID 21620141.2378-2386&rft.date=2007&rft_id=https://api.semanticscholar.org/CorpusID:21620141#id-name=S2CID&rft_id=info:pmid/17420034&rft_id=info:doi/10.1016/j.neuropsychologia.2007.01.017&rft.au=Funnell M. G.&rft.au=Colvin M. K.&rft.au=Gazzaniga M. S.&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  39. ^ a b Gazzaniga, M. S.; Holtzman, J. D.; Deck, M. D.; Lee, B. C. (December 1, 1985). "MRI assessment of human callosal surgery with neuropsychological correlates". Neurology. 35 (12): 1763–1766. doi:10.1212/wnl.35.12.1763. ISSN 0028-3878. PMID 4069368. S2CID 39978354.1763-1766&rft.date=1985-12-01&rft.issn=0028-3878&rft_id=https://api.semanticscholar.org/CorpusID:39978354#id-name=S2CID&rft_id=info:pmid/4069368&rft_id=info:doi/10.1212/wnl.35.12.1763&rft.aulast=Gazzaniga&rft.aufirst=M. S.&rft.au=Holtzman, J. D.&rft.au=Deck, M. D.&rft.au=Lee, B. C.&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  40. ^ Funnell, Margaret G. (2007). "The calculating hemispheres: studies of a split-brain patient". Neuropsychologia. 45 (10): 2378–2386. doi:10.1016/j.neuropsychologia.2007.01.017. PMID 17420034. S2CID 21620141.2378-2386&rft.date=2007&rft_id=https://api.semanticscholar.org/CorpusID:21620141#id-name=S2CID&rft_id=info:pmid/17420034&rft_id=info:doi/10.1016/j.neuropsychologia.2007.01.017&rft.aulast=Funnell&rft.aufirst=Margaret G.&rft_id=https://www.sciencedirect.com/science/article/pii/S002839320700053X&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  41. ^ Turk D. J.; Heatherton T. F.; Kelley W. M.; Funnell M. G.; Gazzaniga M. S.; Macrae C. N. (2002). "Mike or me? Self-recognition in a split-brain patient". Nature Neuroscience. 5 (9): 841–842. doi:10.1038/nn907. PMID 12195428. S2CID 36040335.841-842&rft.date=2002&rft_id=https://api.semanticscholar.org/CorpusID:36040335#id-name=S2CID&rft_id=info:pmid/12195428&rft_id=info:doi/10.1038/nn907&rft.au=Turk D. J.&rft.au=Heatherton T. F.&rft.au=Kelley W. M.&rft.au=Funnell M. G.&rft.au=Gazzaniga M. S.&rft.au=Macrae C. N.&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  42. ^ Funnell M. G.; Corballis P. M.; Gazzaniga M. S. (2000). "Insights into the functional specificity of the human corpus callosum". Brain. 123 (5): 920–926. doi:10.1093/brain/123.5.920. PMID 10775537.920-926&rft.date=2000&rft_id=info:doi/10.1093/brain/123.5.920&rft_id=info:pmid/10775537&rft.au=Funnell M. G.&rft.au=Corballis P. M.&rft.au=Gazzaniga M. S.&rft_id=https://doi.org/10.1093%2Fbrain%2F123.5.920&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  43. ^ Gazzaniga MS, Nass R, Reeves A, Roberts D (1984). "Neurologic perspectives on right hemisphere language following surgical section of the corpus callosum". Seminars in Neurology. 4 (2): 126–135. doi:10.1055/s-2008-1041542. S2CID 260318839.126-135&rft.date=1984&rft_id=info:doi/10.1055/s-2008-1041542&rft_id=https://api.semanticscholar.org/CorpusID:260318839#id-name=S2CID&rft.aulast=Gazzaniga&rft.aufirst=MS&rft.au=Nass, R&rft.au=Reeves, A&rft.au=Roberts, D&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  44. ^ Gazzaniga, M. S. (2000). "Cerebral specialization and interhemispheric communication". Brain. 123 (7): 1293–1326. doi:10.1093/brain/123.7.1293. PMID 10869045.1293-1326&rft.date=2000&rft_id=info:doi/10.1093/brain/123.7.1293&rft_id=info:pmid/10869045&rft.aulast=Gazzaniga&rft.aufirst=M. S.&rft_id=https://doi.org/10.1093%2Fbrain%2F123.7.1293&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  45. ^ Treffert, D. A.; Christensen, D. D. (2006). "Inside the mind of a savant". Scientific American Mind. 17 (3): 52–55. doi:10.1038/scientificamericanmind0606-50. S2CID 1844071.52-55&rft.date=2006&rft_id=info:doi/10.1038/scientificamericanmind0606-50&rft_id=https://api.semanticscholar.org/CorpusID:1844071#id-name=S2CID&rft.aulast=Treffert&rft.aufirst=D. A.&rft.au=Christensen, D. D.&rfr_id=info:sid/en.wikipedia.org:Split-brain" class="Z3988">
  46. ^ a b c Brogaard, B. (November 6, 2012). "The superhuman mind: Split brains". Psychology Today. Retrieved April 26, 2014.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Split-brain&oldid=1244911871"