Wikipedia

Small nucleolar RNA SNORD115

In molecular biology, SNORD115 (also known as HBII-52) is a non-coding RNA (ncRNA) molecule known as a small nucleolar RNA which usually functions in guiding the modification of other non-coding RNAs. This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. HBII-52 refers to the human gene, whereas RBII-52 is used for the rat gene and MBII-52 is used for naming the mouse gene.

Small nucleolar RNA SNORD115
Predicted secondary structure and sequence conservation of SNORD115
Identifiers
SymbolSNORD115
Alt. SymbolssnoHBII-52; HBII-52
RfamRF00105
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

HBII-52 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

In the human genome, HBII-52 is encoded in a tandemly repeated array with another C/D box snoRNA, HBII-85 (SNORD116), in the Prader-Willi syndrome (PWS) region of chromosome 15.[2] However, a microdeletion in one family of the snoRNA HBII-52 cluster has excluded it from playing a major role in the disease.[3] HBII-52 is found in 47 tandem near identical copies on human chromosome 15q11-13. This locus is maternally imprinted, meaning that only the paternal copy of the locus is transcribed. HBII-52 is exclusively expressed in the brain but is absent in PWS patients. HBII-52 lacks any significant complementarity with ribosomal RNAs, but does have an 18 nucleotide region of conserved complementarity to serotonin 2C receptor mRNA.[4] The serotonin 2C receptor is also expressed in the brain. It has been shown that this snoRNA is likely to bind to a silencing element of exon Vb increasing its inclusion and production of a functional spliceform of the serotonin 2C receptor.

The chromosomal locus containing the SNORD115 gene cluster has been duplicated in many individuals with autistic traits.[5][6] A mouse model engineered to have a duplication of the SNORD115 cluster displays autistic-like behaviour.[7]

There is evidence that a truncated form of MBII-52 (SNORD115 found in mouse) regulates the alternative splicing of the protein coding genes DPM2, TAF1, RALGPS1, PBRM1, and CRHR1.[8]

References

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  1. ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.6663-6668&rft.date=2002-10&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC134041#id-name=PMC&rft_id=info:pmid/12215523&rft_id=info:doi/10.1128/MCB.22.19.6663-6668.2002&rft.aulast=Galardi&rft.aufirst=S.&rft.au=Fatica, A.&rft.au=Bachi, A.&rft.au=Scaloni, A.&rft.au=Presutti, C.&rft.au=Bozzoni, I.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC134041&rfr_id=info:sid/en.wikipedia.org:Small nucleolar RNA SNORD115" class="Z3988">
  2. ^ Cavaillé J, Buiting K, Kiefmann M, et al. (2000). "Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14311–6. Bibcode:2000PNAS...9714311C. doi:10.1073/pnas.250426397. PMC 18915. PMID 11106375.14311-6&rft.date=2000&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC18915#id-name=PMC&rft_id=info:pmid/11106375&rft_id=info:doi/10.1073/pnas.250426397&rft_id=info:bibcode/2000PNAS...9714311C&rft.au=Cavaillé J&rft.au=Buiting K&rft.au=Kiefmann M&rft.au=Lalande, M&rft.au=Brannan, CI&rft.au=Horsthemke, B&rft.au=Bachellerie, JP&rft.au=Brosius, J&rft.au=Hüttenhofer, A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC18915&rfr_id=info:sid/en.wikipedia.org:Small nucleolar RNA SNORD115" class="Z3988">
  3. ^ Runte M, Varon R, Horn D, Horsthemke B, Buiting K (2005). "Exclusion of the C/D box snoRNA gene cluster HBII-52 from a major role in Prader-Willi syndrome". Hum Genet. 116 (3): 228–30. doi:10.1007/s00439-004-1219-2. PMID 15565282. S2CID 23190709.228-30&rft.date=2005&rft_id=https://api.semanticscholar.org/CorpusID:23190709#id-name=S2CID&rft_id=info:pmid/15565282&rft_id=info:doi/10.1007/s00439-004-1219-2&rft.aulast=Runte&rft.aufirst=M&rft.au=Varon, R&rft.au=Horn, D&rft.au=Horsthemke, B&rft.au=Buiting, K&rfr_id=info:sid/en.wikipedia.org:Small nucleolar RNA SNORD115" class="Z3988">
  4. ^ Kishore S, Stamm S (January 2006). "The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C". Science. 311 (5758): 230–2. Bibcode:2006Sci...311..230K. doi:10.1126/science.1118265. PMID 16357227. S2CID 44527461.230-2&rft.date=2006-01&rft_id=info:doi/10.1126/science.1118265&rft_id=https://api.semanticscholar.org/CorpusID:44527461#id-name=S2CID&rft_id=info:pmid/16357227&rft_id=info:bibcode/2006Sci...311..230K&rft.aulast=Kishore&rft.aufirst=S&rft.au=Stamm, S&rft_id=https://doi.org/10.1126%2Fscience.1118265&rfr_id=info:sid/en.wikipedia.org:Small nucleolar RNA SNORD115" class="Z3988">
  5. ^ Bolton PF, Veltman MW, Weisblatt E, et al. (September 2004). "Chromosome 15q11-13 abnormalities and other medical conditions in individuals with autism spectrum disorders". Psychiatr. Genet. 14 (3): 131–7. doi:10.1097/00041444-200409500-00002. PMID 15318025. S2CID 37344935.131-7&rft.date=2004-09&rft_id=https://api.semanticscholar.org/CorpusID:37344935#id-name=S2CID&rft_id=info:pmid/15318025&rft_id=info:doi/10.1097/00041444-200409500-00002&rft.au=Bolton PF&rft.au=Veltman MW&rft.au=Weisblatt E&rft.au=Holmes, Joanne R.&rft.au=Thomas, N. Simon&rft.au=Youings, Sheila A.&rft.au=Thompson, Russell J.&rft.au=Roberts, Siân E.&rft.au=Dennis, Nicholas R.&rfr_id=info:sid/en.wikipedia.org:Small nucleolar RNA SNORD115" class="Z3988">
  6. ^ Cook EH, Scherer SW (October 2008). "Copy-number variations associated with neuropsychiatric conditions". Nature. 455 (7215): 919–23. Bibcode:2008Natur.455..919C. doi:10.1038/nature07458. PMID 18923514. S2CID 4377899.919-23&rft.date=2008-10&rft_id=info:doi/10.1038/nature07458&rft_id=https://api.semanticscholar.org/CorpusID:4377899#id-name=S2CID&rft_id=info:pmid/18923514&rft_id=info:bibcode/2008Natur.455..919C&rft.aulast=Cook&rft.aufirst=EH&rft.au=Scherer, SW&rfr_id=info:sid/en.wikipedia.org:Small nucleolar RNA SNORD115" class="Z3988">
  7. ^ Nakatani J, Tamada K, Hatanaka F, et al. (June 2009). "Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism". Cell. 137 (7): 1235–46. doi:10.1016/j.cell.2009.04.024. PMC 3710970. PMID 19563756.1235-46&rft.date=2009-06&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710970#id-name=PMC&rft_id=info:pmid/19563756&rft_id=info:doi/10.1016/j.cell.2009.04.024&rft.au=Nakatani J&rft.au=Tamada K&rft.au=Hatanaka F&rft.au=Ise, Satoko&rft.au=Ohta, Hisashi&rft.au=Inoue, Kiyoshi&rft.au=Tomonaga, Shozo&rft.au=Watanabe, Yasuhito&rft.au=Chung, Yeun Jun&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710970&rfr_id=info:sid/en.wikipedia.org:Small nucleolar RNA SNORD115" class="Z3988">
  8. ^ Kishore S, Khanna A, Zhang Z, Hui J, Balwierz PJ, Stefan M, Beach C, Nicholls RD, Zavolan M, Stamm S (2010). "The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing". Hum Mol Genet. 19 (7): 1153–64. doi:10.1093/hmg/ddp585. PMC 2838533. PMID 20053671.1153-64&rft.date=2010&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838533#id-name=PMC&rft_id=info:pmid/20053671&rft_id=info:doi/10.1093/hmg/ddp585&rft.aulast=Kishore&rft.aufirst=S&rft.au=Khanna, A&rft.au=Zhang, Z&rft.au=Hui, J&rft.au=Balwierz, PJ&rft.au=Stefan, M&rft.au=Beach, C&rft.au=Nicholls, RD&rft.au=Zavolan, M&rft.au=Stamm, S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838533&rfr_id=info:sid/en.wikipedia.org:Small nucleolar RNA SNORD115" class="Z3988">
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