Signet ring cell

In histology, a signet ring cell is a cell with a large vacuole. The malignant type is seen predominantly in carcinomas. Signet ring cells are most frequently associated with stomach cancer,^[1] but can arise from any number of tissues including the prostate,^[2] bladder, gallbladder,^[3] breast, colon,^[4] ovarian stroma and testis.^[5]

Types

The NCI Thesaurus identifies the following types of signet ring cell

Castration cell, a non-malignant cell arising in the anterior pituitary gland under certain abnormal hormonal conditions.
Neoplastic thyroid gland follicular signet ring cell
Signet ring adenocarcinoma cell
Signet ring melanoma cell
Signet ring stromal cell

Appearance

The name of the cell comes from its appearance; signet ring cells resemble signet rings. They contain a large amount of mucin, which pushes the nucleus to the cell periphery. The pool of mucin in a signet ring cell mimics the appearance of a finger hole and the nucleus mimics the appearance of the face of the ring in profile.

Gastric signet ring cell carcinoma. H&E stain.
A signet ring-like foamy macrophage, which may mimic a cancer cell, but the texture of the nucleus is similar to that of a normal macrophage.
High magnification micrograph showing signet ring cells, with clear cytoplasm, in metastatic breast carcinoma. H&E stain.
Signet ring cells (magenta) stained with PAS in a gastric signet ring cell carcinoma.

Diagnostic significance

A significant number of signet ring cells, generally, are associated with a worse prognosis.^[6]^[7]

Classification of carcinomas

SRC carcinomas can be classified using immunohistochemistry.^[8]

References

^ Cancer Research UK. Signet Ring Cancer. cancerhelp.org.uk. URL: http://www.cancerhelp.org.uk/help/default.asp?page=7581 Archived 2007-10-14 at the Wayback Machine. Accessed on: November 2, 2007.
^ Leong FJ, Leong AS, Swift J (1996). "Signet-ring carcinoma of the prostate". Pathol. Res. Pract. 192 (12): 1232–8, discussion 1239–41. doi:10.1016/S0344-0338(96)80156-7. PMID 9182294.1232-8, discussion 1239-41&rft.date=1996&rft_id=info:doi/10.1016/S0344-0338(96)80156-7&rft_id=info:pmid/9182294&rft.aulast=Leong&rft.aufirst=FJ&rft.au=Leong, AS&rft.au=Swift, J&rfr_id=info:sid/en.wikipedia.org:Signet ring cell" class="Z3988">
^ Jain V, Gupta K, Kudva R, Rodrigues GS (2006). "A case of ovarian metastasis of gallbladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of literature". Int. J. Gynecol. Cancer. 16 Suppl 1: 319–21. doi:10.1111/j.1525-1438.2006.00335.x. PMID 16515613.319-21&rft.date=2006&rft_id=info:doi/10.1111/j.1525-1438.2006.00335.x&rft_id=info:pmid/16515613&rft.aulast=Jain&rft.aufirst=V&rft.au=Gupta, K&rft.au=Kudva, R&rft.au=Rodrigues, GS&rfr_id=info:sid/en.wikipedia.org:Signet ring cell" class="Z3988">
^ Makino T, Tsujinaka T, Mishima H, et al. (2006). "Primary signet-ring cell carcinoma of the colon and rectum: report of eight cases and review of 154 Japanese cases". Hepatogastroenterology. 53 (72): 845–9. PMID 17153438.845-9&rft.date=2006&rft_id=info:pmid/17153438&rft.aulast=Makino&rft.aufirst=T&rft.au=Tsujinaka, T&rft.au=Mishima, H&rfr_id=info:sid/en.wikipedia.org:Signet ring cell" class="Z3988">
^ Michal M, Hes O, Kazakov DV (2005). "Primary signet-ring stromal tumor of the testis". Virchows Arch. 447 (1): 107–10. doi:10.1007/s00428-005-1218-2. PMID 15909171.107-10&rft.date=2005&rft_id=info:doi/10.1007/s00428-005-1218-2&rft_id=info:pmid/15909171&rft.aulast=Michal&rft.aufirst=M&rft.au=Hes, O&rft.au=Kazakov, DV&rfr_id=info:sid/en.wikipedia.org:Signet ring cell" class="Z3988">
^ Lee WS, Chun HK, Lee WY, et al. (2007). "Treatment outcomes in patients with signet ring cell carcinoma of the colorectum". Am. J. Surg. 194 (3): 294–8. doi:10.1016/j.amjsurg.2006.12.041. PMID 17693269.294-8&rft.date=2007&rft_id=info:doi/10.1016/j.amjsurg.2006.12.041&rft_id=info:pmid/17693269&rft.aulast=Lee&rft.aufirst=WS&rft.au=Chun, HK&rft.au=Lee, WY&rfr_id=info:sid/en.wikipedia.org:Signet ring cell" class="Z3988">
^ Cabebe EC, Mehta VK, Fisher G. Gastric Cancer. eMedicine.com. URL: http://www.emedicine.com/med/topic845.htm. Accessed on: November 8, 2007.
^ Tian MM, Zhao AL, Li ZW, Li JY (2007). "Phenotypic classification of gastric signet ring cell carcinoma and its relationship with clinicopathologic parameters and prognosis". World J. Gastroenterol. 13 (23): 3189–98. PMID 17589897.3189-98&rft.date=2007&rft_id=info:pmid/17589897&rft.aulast=Tian&rft.aufirst=MM&rft.au=Zhao, AL&rft.au=Li, ZW&rft.au=Li, JY&rfr_id=info:sid/en.wikipedia.org:Signet ring cell" class="Z3988">

External links

Signet ring cells - med.Utah.edu.
Signet ring cell definition - cancer.gov.
Signet ring cell cancer information - sites.google.com/site/signetringcancer.

[1] Cancer Research UK. Signet Ring Cancer. cancerhelp.org.uk. URL: http://www.cancerhelp.org.uk/help/default.asp?page=7581 Archived 2007-10-14 at the Wayback Machine. Accessed on: November 2, 2007.

[2] Leong FJ, Leong AS, Swift J (1996). "Signet-ring carcinoma of the prostate". Pathol. Res. Pract. 192 (12): 1232–8, discussion 1239–41. doi:10.1016/S0344-0338(96)80156-7. PMID 9182294.1232-8, discussion 1239-41&rft.date=1996&rft_id=info:doi/10.1016/S0344-0338(96)80156-7&rft_id=info:pmid/9182294&rft.aulast=Leong&rft.aufirst=FJ&rft.au=Leong, AS&rft.au=Swift, J&rfr_id=info:sid/en.wikipedia.org:Signet ring cell" class="Z3988">

[3] Jain V, Gupta K, Kudva R, Rodrigues GS (2006). "A case of ovarian metastasis of gallbladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of literature". Int. J. Gynecol. Cancer. 16 Suppl 1: 319–21. doi:10.1111/j.1525-1438.2006.00335.x. PMID 16515613.319-21&rft.date=2006&rft_id=info:doi/10.1111/j.1525-1438.2006.00335.x&rft_id=info:pmid/16515613&rft.aulast=Jain&rft.aufirst=V&rft.au=Gupta, K&rft.au=Kudva, R&rft.au=Rodrigues, GS&rfr_id=info:sid/en.wikipedia.org:Signet ring cell" class="Z3988">

[4] Makino T, Tsujinaka T, Mishima H, et al. (2006). "Primary signet-ring cell carcinoma of the colon and rectum: report of eight cases and review of 154 Japanese cases". Hepatogastroenterology. 53 (72): 845–9. PMID 17153438.845-9&rft.date=2006&rft_id=info:pmid/17153438&rft.aulast=Makino&rft.aufirst=T&rft.au=Tsujinaka, T&rft.au=Mishima, H&rfr_id=info:sid/en.wikipedia.org:Signet ring cell" class="Z3988">

[5] Michal M, Hes O, Kazakov DV (2005). "Primary signet-ring stromal tumor of the testis". Virchows Arch. 447 (1): 107–10. doi:10.1007/s00428-005-1218-2. PMID 15909171.107-10&rft.date=2005&rft_id=info:doi/10.1007/s00428-005-1218-2&rft_id=info:pmid/15909171&rft.aulast=Michal&rft.aufirst=M&rft.au=Hes, O&rft.au=Kazakov, DV&rfr_id=info:sid/en.wikipedia.org:Signet ring cell" class="Z3988">

[6] Lee WS, Chun HK, Lee WY, et al. (2007). "Treatment outcomes in patients with signet ring cell carcinoma of the colorectum". Am. J. Surg. 194 (3): 294–8. doi:10.1016/j.amjsurg.2006.12.041. PMID 17693269.294-8&rft.date=2007&rft_id=info:doi/10.1016/j.amjsurg.2006.12.041&rft_id=info:pmid/17693269&rft.aulast=Lee&rft.aufirst=WS&rft.au=Chun, HK&rft.au=Lee, WY&rfr_id=info:sid/en.wikipedia.org:Signet ring cell" class="Z3988">

[7] Cabebe EC, Mehta VK, Fisher G. Gastric Cancer. eMedicine.com. URL: http://www.emedicine.com/med/topic845.htm. Accessed on: November 8, 2007.

[8] Tian MM, Zhao AL, Li ZW, Li JY (2007). "Phenotypic classification of gastric signet ring cell carcinoma and its relationship with clinicopathologic parameters and prognosis". World J. Gastroenterol. 13 (23): 3189–98. PMID 17589897.3189-98&rft.date=2007&rft_id=info:pmid/17589897&rft.aulast=Tian&rft.aufirst=MM&rft.au=Zhao, AL&rft.au=Li, ZW&rft.au=Li, JY&rfr_id=info:sid/en.wikipedia.org:Signet ring cell" class="Z3988">

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