The enzyme scytalone dehydratase (EC 4.2.1.94) catalyzes the chemical reaction
| scytalone dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.94 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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- scytalone 1,3,8-trihydroxynaphthalene H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming). This enzyme is also called scytalone 7,8-hydro-lyase.
Structural studies
editAs of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1IDP, 1STD, 2STD, 3STD, 4STD, 5STD, 6STD, and 7STD.
References
edit- Butler MJ, Lazarovits G, Higgins VJ, Lachance MA (1988). "Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi". Exp. Mycol. 12 (4): 367–376. doi:10.1016/0147-5975(88)90028-X.367-376&rft.date=1988&rft_id=info:doi/10.1016/0147-5975(88)90028-X&rft.aulast=Butler&rft.aufirst=MJ&rft.au=Lazarovits, G&rft.au=Higgins, VJ&rft.au=Lachance, MA&rfr_id=info:sid/en.wikipedia.org:Scytalone dehydratase" class="Z3988">
- Tajima S, Kubo Y, Furusawa I, Shishiyama J (1989). "Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus". Exp. Mycol. 13: 69–76. doi:10.1016/0147-5975(89)95009-1.69-76&rft.date=1989&rft_id=info:doi/10.1016/0147-5975(89)95009-1&rft.aulast=Tajima&rft.aufirst=S&rft.au=Kubo, Y&rft.au=Furusawa, I&rft.au=Shishiyama, J&rfr_id=info:sid/en.wikipedia.org:Scytalone dehydratase" class="Z3988">
- Wheeler MH; Greenblatt GA (1988). "The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease". Exp. Mycol. 12 (2): 151–160. doi:10.1016/0147-5975(88)95004-7.151-160&rft.date=1988&rft_id=info:doi/10.1016/0147-5975(88)95004-7&rft.au=Wheeler MH&rft.au=Greenblatt GA&rfr_id=info:sid/en.wikipedia.org:Scytalone dehydratase" class="Z3988">
